Cochlear and Brainstem Implantation

Toh, Elizabeth H.; Luxford, William M.

doi:10.1016/j.nec.2008.02.014

Cited by 28 publications

(23 citation statements)

References 29 publications

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“…In addition, the aging population shows widely different levels of hearing loss (Toh et al, 2002; Gopinath, 2010). Recent studies suggest that sound exposure and aging result in increased neuronal activity in the auditory brainstem and auditory cortex (Hughes et al, 2010; Schmidt et al, 2010; Syka, 2002 for review; Caspary et al, 2008 for review).…”

Section: Discussionmentioning

confidence: 99%

Impact of sound exposure and aging on brain-derived neurotrophic factor and tyrosine kinase B receptors levels in dorsal cochlear nucleus 80 days following sound exposure

et al. 2011

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Recent studies suggested that acute sound exposure resulting in a temporary threshold shift in young adult animals within a series of maladaptive plasticity changes in central auditory structures. Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, is involved in post-trauma peripheral hair cell and spiral ganglion cell survival and has been shown to modulate synaptic strength in cochlear nucleus following sound exposure. The present study evaluated levels of BDNF and its receptor (tyrosine kinase B, [TrkB]) in the dorsal cochlear nucleus (DCN) following a unilateral moderate sound exposure in young (7–8 months) and aged (28–29 months) Fischer Brown Norway (FBN) rats. Eighty days post-exposure, ABR thresholds for young exposed rats approached control values while aged exposed rats showed residual permanent threshold shifts relative to aged controls. BDNF protein levels were significantly up-regulated by 9% in young exposed fusiform cells ipsilateral to the exposure. BDNF levels in aged sound-exposed fusiform cells increased 31% ipsilateral to the exposure. Protein levels of the BDNF receptor, TrkB, were also significantly increased in aged but not in young sound-exposed DCN fusiform cells. The present findings suggest a relationship between the up-regulation of BDNF/TrkB and the increase in spontaneous and driven activity previously observed for aged and sound-exposed fusiform cells. This might be due to a selective maladaptive compensatory down-regulation of glycinergic inhibition in DCN fusiform cells.

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Section: Discussionmentioning

confidence: 99%

Impact of sound exposure and aging on brain-derived neurotrophic factor and tyrosine kinase B receptors levels in dorsal cochlear nucleus 80 days following sound exposure

et al. 2011

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“…The main indication for ABI is hearing restoration in patients with Neurofibromatosis Type 2 (NF2) who have lost their cochlear nerve during surgery and have therefore been rendered profoundly deaf (2). A second emerging indication is hearing rehabilitation in children who have congenitally absent or hypoplastic cochlear nerves (3).…”

mentioning

confidence: 99%

Subjective Outcomes of Auditory Brainstem Implantation

McSorley¹,

Freeman²,

Ramsden³

et al. 2015

Otology &Amp; Neurotology

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This study demonstrates that ABI users make use of their device for at least 12 hours per day on average and obtain considerable subjective benefit in speech discrimination when using the device with familiar speakers in a quiet environment. Benefit is less significant in noise and with an unfamiliar speaker. Lip reading enhances subjective benefit by at least 1 point, and lip reading training may have a role to play in maximizing subjective benefit.

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“…The House Clinic reported that up to one-third of postlingual adults undergoing implantation achieve open-set speech recognition [3]. Poor performers benefit from environmental sounds awareness and assisted lip reading skills.…”

Section: Reported Outcomes In Patients Undergoing Cochlear Implantmentioning

confidence: 99%

“…In the House Clinic review on ABI, 85% of patients perceived auditory sensation [3]. Combined with lip reading cues, 93% of patients improved sentence understanding in 3 to 6 months.…”

Section: Reported Outcomes In Patients Undergoing Cochlear Implantmentioning

confidence: 99%

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Cochlear Implantation in Patients with Neurofibromatosis Type 2 and Patients with Vestibular Schwannoma in the Only Hearing Ear

Celis‐Aguilar

Lassaletta

Gavilán

2012

International Journal of Otolaryngology

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Cochlear implants are a new surgical option in the hearing rehabilitation of patients with neurofibromatosis type 2 (NF2) and patients with vestibular schwannoma (VS) in the only hearing ear. Auditory brainstem implant (ABI) has been the standard surgical treatment for these patients. We performed a literature review of patients with NF2 and patients with VS in the only hearing ear. Cochlear implantation (CI) provided some auditory benefit in all patients. Preservation of cochlear nerve integrity is crucial after VS resection. Results ranged from environmental sound awareness to excellent benefit with telephone use. Promontory stimulation is recommended although not crucial. MRI can be performed safely in cochlear implanted patients.

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Cochlear and Brainstem Implantation

Cited by 28 publications

References 29 publications

Impact of sound exposure and aging on brain-derived neurotrophic factor and tyrosine kinase B receptors levels in dorsal cochlear nucleus 80 days following sound exposure

Impact of sound exposure and aging on brain-derived neurotrophic factor and tyrosine kinase B receptors levels in dorsal cochlear nucleus 80 days following sound exposure

Subjective Outcomes of Auditory Brainstem Implantation

Cochlear Implantation in Patients with Neurofibromatosis Type 2 and Patients with Vestibular Schwannoma in the Only Hearing Ear

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