Cochlear function in young and adult Fischer 344 rats

Popelář, Jiří; Groh, Daniel; Mazelová, Jana; Syka, Josef

doi:10.1016/s0378-5955(03)00329-0

Cited by 34 publications

(26 citation statements)

References 57 publications

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“…In previous studies, hearing threshold of rats from different strains was examined using both electrophysiological and behavioral methods. In behavioral studies, although rats' hearing threshold was lower than what was recorded in this research (20), the audiogram pattern observed in the present study corresponded with what was reported in previous research (21). In behavioral studies, rats hearing was most sensitive within the range of 8 to 32 kHz (20), and in studies performed using electro-physiological techniques, sensitivity was highest at frequencies of 8 (7, 21) and 16 (5) kHz.…”

Section: Discussionsupporting

confidence: 87%

The Effect of Prenatal Stress on Auditory Brainstem Responses in Rat Pups

et al. 2018

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Background: Recent epidemiological evidence indicates that the fetal environment can influence susceptibility to later disease during the lifespan. Prenatal stress exposure alters the programming of the metabolic and endocrine balance of various organs, including the auditory system. Objectives: The current study aimed at evaluating how prenatal stress influences Auditory Brainstem Responses. Methods: Eighteen pregnant Wistar rats were stressed during a one-month gestation by chronic mild stress (CMS, a variable schedule of different stressors). After birth, the offspring's hearing thresholds and latencies were evaluated and compared with the control group. The hearing thresholds were assessed by recording auditory evoked brainstem responses to 4, 8,12, and 16 kHz tone burst. Results:The results showed that although CMS caused a significant increase in corticosterone in pregnant mothers, the offspring with CMS experience had significantly lower body weight than control animals (P < 0.00) yet there was no difference between hearing sensitivity of prenatally stressed offspring and the control group. However, ABRs showed a marked prolongation in wave II and IV latencies in prenatally stressed rats (P < 0.05). Conclusion:The current data confirmed that prenatal exposure to mild stress is not detrimental to hearing sensitivity. However, these data suggest that prenatal stress can affect the temporal processing of auditory stimuli in the brainstem.

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Section: Discussionsupporting

confidence: 87%

The Effect of Prenatal Stress on Auditory Brainstem Responses in Rat Pups

et al. 2018

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“…In summary, the number of PV-ir neurons increased with age in the CIC in the Long Evans strain, whereas in the with Long Evans rats, resulting in larger hearing threshold shifts, a decrease in the amplitude of click-evoked auditory brainstem responses, a diminution of distortion product otoacoustic emissions and a decrease in middle-ear compliance (Popelar et al 2003(Popelar et al , 2006. Age-related…”

Section: Discussionmentioning

confidence: 88%

“…In many tasks, a tone stimulus was used for fear conditioning (Oler and Markus, 1998;Villareal et al, 2004). Since old Fischer 344 rats are hearing-impaired with large hearing losses (Popelar et al, 2003(Popelar et al, , 2006Buckiova 2007), the results of those experiments may also have been influenced by the limited hearing abilities of the aged animals. The relationship ACCEPTED MANUSCRIPT A C C E P T E D M A N U S C R I P T 16 between a decline in hippocampal PV-ir neuronal networks and cognitive deficits in the same strain may suggest that the large decline in the number of PV-ir neurons in the auditory cortex in Fischer 344 rats could contribute to the deterioration of hearing function in these animals.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Changes in parvalbumin immunoreactivity with aging in the central auditory system of the rat

Ouda¹,

Druga²,

Syka³

2008

Experimental Gerontology

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“…In the human population, a loss of speech understanding with aging constitutes an important health and social impairment Mazelova et al, 2003;Gordon-Salant et al, 2007). Pathological changes in presbycusis occur both in the inner ear and in the central auditory system.…”

Section: Introductionmentioning

confidence: 99%

“…Inhibitory systems in the brain are apparently strongly involved in the temporal processing of acoustical stimuli with the aim of sharpening responses to rapid complex sounds (Walton et al, 1997;Strouse et al, 1998;Krishna and Semple, 2000;Liang et al, 2002;Tremblay et al, 2002;Ostroff et al,2003;Mazelova et al, 2003). Since gama-aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the central auditory system (Markram et al, 2004), a decrease in GABA inhibition may significantly contribute to hearing deterioration with aging.…”

Section: Introductionmentioning

confidence: 99%