Cochlear Implant Surgery and Electrically-evoked Auditory Brainstem Response Recordings in C57BL/6 Mice

Navntoft, Charlotte Amalie; Marozeau, Jérémy; Barkat, Tania Rinaldi

doi:10.3791/58073

Cited by 7 publications

(5 citation statements)

References 23 publications

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“…Prior to capturing IC responses, ABRs were recorded each time a coil or electrode was inserted (or reinserted) into the cochlea (see Materials and methods) to provide a relatively quick validation that a given surgical procedure had not damaged the early auditory pathways or the implant itself. ABRs to electric stimulation (eABRs; Figure 3D ) were generally similar to those reported previously in mice ( Navntoft et al, 2019 ) and other laboratory animals ( Miller et al, 1995 ), with multiple peaks occurring within the first few milliseconds following stimulus onset. ABR waveforms to magnetic stimulation (mABR; Figure 3C ) also consisted of a number of peaks, although the amplitudes of the early and later peaks were about the same.…”

Section: Resultssupporting

confidence: 84%

Magnetic stimulation allows focal activation of the mouse cochlea

Lee

Seist

McInturff

et al. 2022

eLife

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Cochlear implants (CIs) provide sound and speech sensations for patients with severe to profound hearing loss by electrically stimulating the auditory nerve. While most CI users achieve some degree of open set word recognition under quiet conditions, hearing that utilizes complex neural coding (e.g., appreciating music) has proved elusive, probably because of the inability of CIs to create narrow regions of spectral activation. Several novel approaches have recently shown promise for improving spatial selectivity, but substantial design differences from conventional CIs will necessitate much additional safety and efficacy testing before clinical viability is established. Outside the cochlea, magnetic stimulation from small coils (micro-coils) has been shown to confine activation more narrowly than that from conventional microelectrodes, raising the possibility that coil-based stimulation of the cochlea could improve the spectral resolution of CIs. To explore this, we delivered magnetic stimulation from micro-coils to multiple locations of the cochlea and measured the spread of activation utilizing a multielectrode array inserted into the inferior colliculus; responses to magnetic stimulation were compared to analogous experiments with conventional microelectrodes as well as to responses when presenting auditory monotones. Encouragingly, the extent of activation with micro-coils was ~60% narrower compared to electric stimulation and largely similar to the spread arising from acoustic stimulation. The dynamic range of coils was more than three times larger than that of electrodes, further supporting a smaller spread of activation. While much additional testing is required, these results support the notion that magnetic micro-coil CIs can produce a larger number of independent spectral channels and may therefore improve auditory outcomes. Further, because coil-based devices are structurally similar to existing CIs, fewer impediments to clinical translational are likely to arise.

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Section: Resultssupporting

confidence: 84%

Magnetic stimulation allows focal activation of the mouse cochlea

Lee

Seist

McInturff

et al. 2022

eLife

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“…ABRs to electric stimulation (eABRs; Fig. 2D) were generally similar to those reported previously in mice (31) and other laboratory animals (32), with multiple peaks occurring within the first few milliseconds following stimulus onset. ABR waveforms to magnetic stimulation (mABR; Fig.…”

Section: Robust Activation Of the Auditory System By Magnetic Stimula...supporting

confidence: 84%

Magnetic Stimulation Allows Focal Activation of the Mouse Cochlea

Lee

Seist

McInturff

et al. 2022

Preprint

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Cochlear implants (CIs) strive to restore hearing to those with severe to profound hearing loss by artificially stimulating the auditory nerve. While most CI users can understand speech in a quiet environment, hearing that utilizes complex neural coding (e.g., appreciating music) has proved elusive, probably because of the inability of CIs to create narrow regions of spectral activation. Several novel approaches have recently shown promise for improving spatial selectivity, but substantial design differences from conventional CIs will necessitate much additional safety testing before clinical viability is established. Outside the cochlea, magnetic stimulation from small coils (micro-coils) has been shown to confine activation more narrowly than that from conventional micro-electrodes, raising the possibility that coil-based stimulation of the cochlea could improve the spectral resolution of CIs. To explore this, we delivered magnetic stimulation from micro-coils to multiple locations of the cochlea and measured the spread of activation utilizing a multi-electrode array inserted into the inferior colliculus; responses to magnetic stimulation were compared to analogous experiments with conventional micro-electrodes as well as to the responses to auditory monotones. Encouragingly, the extent of activation with micro-coils was ~60% narrower than that from electric stimulation and largely similar to the spread arising from acoustic stimulation. The dynamic range of coils was more than three times larger than that of electrodes, further supporting a smaller spread of activation. While much additional testing is required, these results support the notion that coil-based CIs can produce a larger number of independent spectral channels and may therefore improve functional performance. Further, because coil-based devices are structurally similar to existing CIs, fewer impediments to clinical translational are likely to arise.

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“…The left ear was used as the experimental ear. Details of the surgical approach and electrode array are provided in Navntoft et al 54 .…”

Section: Methodsmentioning

confidence: 99%

Ramped pulse shapes are more efficient for cochlear implant stimulation in an animal model

Navntoft

Marozeau

Barkat

2020

Sci Rep

Self Cite

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In all commercial cochlear implant (CI) devices, the electric stimulation is performed with a rectangular pulse that generally has two phases of opposite polarity. To date, developing new stimulation strategies has relied on the efficacy of this shape. Here, we investigate the potential of a novel stimulation paradigm that uses biophysically-inspired electrical ramped pulses. Using electrically-evoked auditory brainstem response (eABR) recordings in mice, we found that less charge, but higher current level amplitude, is needed to evoke responses with ramped shapes that are similar in amplitude to responses obtained with rectangular shapes. The most charge-efficient pulse shape had a rising ramp over both phases, supporting findings from previous in vitro studies. This was also true for longer phase durations. Our study presents the first physiological data on CI-stimulation with ramped pulse shapes. By reducing charge consumption ramped pulses have the potential to produce more battery-efficient CIs and may open new perspectives for designing other efficient neural implants in the future.

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Cochlear Implant Surgery and Electrically-evoked Auditory Brainstem Response Recordings in C57BL/6 Mice

Cited by 7 publications

References 23 publications

Magnetic stimulation allows focal activation of the mouse cochlea

Magnetic stimulation allows focal activation of the mouse cochlea

Magnetic Stimulation Allows Focal Activation of the Mouse Cochlea

Ramped pulse shapes are more efficient for cochlear implant stimulation in an animal model

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