2020
DOI: 10.3390/foods9101359
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Cocoa (Theobroma cacao L.) Seed Proteins’ Anti-Obesity Potential through Lipase Inhibition Using In Silico, In Vitro and In Vivo Models

Abstract: The aim of this study was to determine the pancreatic lipase (PL) inhibitory effect of cocoa protein (CP) hydrolysates (CPH) using in silico and in vitro approaches, and an in vivo high-fat diet (HF) obese rat model. The results showed better theoretical affinity on PL for cocoa peptides EEQR, GGER, QTGVQ, and VSTDVNIE released from vicilin and albumins (−6.5, −6.3, −6.2, and −6.1 kcal/mol, respectively). Absorption, distribution, metabolism, and excretion (ADMET) prediction showed the human intestinal absorpt… Show more

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Cited by 41 publications
(28 citation statements)
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“…This observation is supported by a recent study, showing a high correlation between the ADMET predicted values and experimental results on the bioactivity and intestinal absorption of ACE inhibitory peptides (Zhao et al, 2019). Regarding hepatotoxicity, the peptides SDLFENL, LSPGDVFVVPAGHPVA, LSPGDVFVVPAGHPV, FLPQFTDADF in lentil and FFEITPK and ATPADVLANAFGL in fava bean showed low probability values (<0.6) that were smaller than those previously calculated for cocoa peptides (Coronado-Cáceres et al, 2020). The peptide SDLFENL identified in all lentil types and the peptide QQQPDSHQKIRR in ZF showed the lowest values of acute oral toxicity (2.1 and 2.3 kg/mol, respectively), whereas LSPGDVFVVPAGHPV found in GZL and BL lentils and LSPGDVLVIPAGYPVAIK in ZF exhibited the highest acute oral toxicity (3.4 and 3.2 kg/mol, respectively).…”
Section: Variations In the Bioactive Potential Of Digestion-resistant Peptides In Dry Seeds And Sprouts Of Lentil And Fava Bean Seed Typesupporting
confidence: 80%
“…This observation is supported by a recent study, showing a high correlation between the ADMET predicted values and experimental results on the bioactivity and intestinal absorption of ACE inhibitory peptides (Zhao et al, 2019). Regarding hepatotoxicity, the peptides SDLFENL, LSPGDVFVVPAGHPVA, LSPGDVFVVPAGHPV, FLPQFTDADF in lentil and FFEITPK and ATPADVLANAFGL in fava bean showed low probability values (<0.6) that were smaller than those previously calculated for cocoa peptides (Coronado-Cáceres et al, 2020). The peptide SDLFENL identified in all lentil types and the peptide QQQPDSHQKIRR in ZF showed the lowest values of acute oral toxicity (2.1 and 2.3 kg/mol, respectively), whereas LSPGDVFVVPAGHPV found in GZL and BL lentils and LSPGDVLVIPAGYPVAIK in ZF exhibited the highest acute oral toxicity (3.4 and 3.2 kg/mol, respectively).…”
Section: Variations In the Bioactive Potential Of Digestion-resistant Peptides In Dry Seeds And Sprouts Of Lentil And Fava Bean Seed Typesupporting
confidence: 80%
“…Based on Cabezas-Zabala et al (30), the increased consumption of monosaturated and polyunsaturated fatty acids can reduce LDL cholesterol, resulting in a growing interest in incorporating these bioactive lipids in functional foods designed to produce certain health benefits, such as anti-inflammatory, antioxidant, anticancer and cholesterollowering properties (29). Cocoa protein and its peptides could be developed as an ingredient in the formulation of new functional foods aimed at mitigating obesity and associated disorders (31).…”
Section: Discussionmentioning
confidence: 99%
“…The rats were acclimatized for one week with unlimited access to food and water. A total of 21 rats were used and randomly divided into three dietary groups (n = 7 per group) as follows [20,35]: Standard Diet (STD group, 3.1 kcal/g) (TD.05230; Teklad Global Harlan Laboratories, Inc., Madison, WI, USA), High-Fat diet (HF group, 4.5 kcal/g) (TD.88137; Teklad Global Harlan Laboratories, Inc.), and HF-diet, supplemented with 150 mg CP/kg/day through orogastric administration once daily (HF + CP group). The experimental period was 8 weeks.…”
Section: Animal Assaymentioning
confidence: 99%
“…All animals were fed ad libitum with free access to water during the experimental period (8 weeks). The use of male Wistar rats was approved by the Ethics and Research Committee of the National School of Biological Sciences of the National Polytechnic Institute from Mexico [18,20,35,36].…”
Section: Animal Assaymentioning
confidence: 99%