Coding polymorphisms in Casp5, Casp8 and DR4 genes may play a role in predisposition to lung cancer

Ulybina, Yulia M.; Kuligina, Ekatherina Sh.; Mitiushkina, Natalia V.; Rozanov, Maxim E.; Ivantsov, Alexandr O.; Ponomariova, Daria N.; Togo, Alexandr V.; Levchenko, Evgeny; Shutkin, Vladimir A.; Brenister, Sergiu I.; Devilee, Peter; Zhivotovsky, Boris; Hirvonen, Ari; Imyanitov, Evgeny N.

doi:10.1016/j.canlet.2009.01.012

Cited by 36 publications

(36 citation statements)

References 30 publications

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“…According to the inclusion criteria, 9 studies (Xie, 2004;Lan et al, 2007;Hosgood et al, 2008;Lee et al, 2009;Ulybina et al, 2009;Xu et al, 2009;Lei, 2010;Ni et al, 2011;Mittal et al, 2012) were included in the meta-analysis and 96 were excluded. The flow chart of study selection is shown in Figure 1.…”

Section: Characteristics Of the Studies Includedmentioning

confidence: 99%

HuGE systematic review and meta-analysis demonstrate association of CASP-3 and CASP-7 genetic polymorphisms with cancer risk

Yan¹,

Li²,

Zhu³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. Genetic variations in the caspase genes CASP-3 and CASP-7 are known to be involved in apoptosis, cytokine maturation, cell growth and differentiation. Polymorphisms of CASP-3 and CASP-7 genes have been increasingly recognized as important regulators in the development of cancer. However, whether there is a specific association is still controversial. Therefore, we made a Human Genome Epidemiology review and meta-analysis to explore the association between polymorphisms of CASP-3 and CASP-7 genes and cancer risk. Based on the inclusion criteria, we examined 9 case-control studies, with a total of 3142 cancer cases and 3670 healthy controls. Meta-analysis results showed that the homozygote (CC) of rs2705897 in the CASP-3 gene is positively associated with cancer susceptibility [odds ratio (OR) = 4.36, 95% confidence interval (CI) = 1.26-15.11, P = 0.02], while the C allele and C carrier (TC+CC) of rs1049216 are negatively associated with cancer risk (OR = 0.81, 95%CI = 0.69-0.95, P = 0.01; OR = 0.78, 95%CI= 0.63-0.97, P = 0.02, respectively). The G allele and G carrier of rs4647603 (A/G) in CASP-3 had positive associations with cancer susceptibility (OR = 1.69, 95%CI = 1.37-2.09, P < 0.001; OR = 1.93, 95%CI = 1.26-2.93, P = 0.002, respectively). The T allele of rs12415607, the G allele and homozygote (GG) of rs2227310, and homozygote (CC) of rs3124740 also had positive associations with cancer risk (OR = 1.18, 95%CI = 1.02-1.37, P = 0.03; OR = 1.17, 95%CI = 1.01-1.34, P = 0.03; OR = 1.34, 95%CI = 1.04-1.74, P = 0.03; OR = 1.30, 95%CI = 1.04-1.63, P = 0.02, respectively). In addition, homozygote (AA) of rs11196418 showed a significant negative association with cancer risk (OR = 0.36, 95%CI = 0.14-0.93, P = 0.03). These meta-analysis results demonstrated that CASP-3 and CASP-7 genetic polymorphisms are involved in the pathogenesis of cancer.

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Section: Characteristics Of the Studies Includedmentioning

confidence: 99%

HuGE systematic review and meta-analysis demonstrate association of CASP-3 and CASP-7 genetic polymorphisms with cancer risk

Yan¹,

Li²,

Zhu³

et al. 2013

Genet. Mol. Res.

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“…Similarly, no association was found between CASP-10 polymorphisms and susceptibility to lymphoma, myeloma, melanoma, or lung cancer (all P > 0.05). The significance of pooled OR in all individual analyses was not influenced excessively by omitting any single study and non-HWE studies (Ulybina et al, 2009 Table 3. Meta-analysis of the association between CASP-10 gene polymorphisms and cancer risk.…”

Section: The Characteristics Of the Studies Includedmentioning

confidence: 95%

“…According to the inclusion criteria, 8 studies (MacPherson et al, 2004;Ye, 2004;Frank et al, 2006;Lan et al, 2007;Hosgood et al, 2008;Li et al, 2008;Gaudet et al, 2009;Ulybina et al, 2009) were included and 97 were excluded. A flow chart of the study selection process is shown in Figure 1.…”

Section: The Characteristics Of the Studies Includedmentioning

confidence: 99%

Role of CASP-10 gene polymorphisms in cancer susceptibility: a HuGE review and meta-analysis

Yan¹,

Li²,

Zhu³

et al. 2012

Genet. Mol. Res.

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ABSTRACT.We investigated a possible association between CASP-10 gene polymorphisms and susceptibility to cancer through a meta-analysis. Eight studies with a total of 29,936 cancer cases and 34,041 healthy controls were included. Meta-analysis results showed that the rs13006529*T carrier was significantly associated with increased cancer risk (OR = 1.17, 95%CI = 1.01-1.36, P = 0.03). However, rs3900115 and rs13010627 showed no association with cancer susceptibility (all P > 0.05). In the subgroup analysis by cancer type, we found that the rs13006529*T carrier was a risk factor for breast cancer (OR = 1.17, 95%CI = 1.01-1.36, P = 0.03). Similarly, no association was found between CASP-10 polymorphisms and susceptibility to lymphoma, myeloma, melanoma, or lung cancer (all P > 0.05). This meta-analysis suggests that the rs13006529*T carrier in the CASP-10 gene might be a risk factor for cancer susceptibility, especially for breast cancer.

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“…Some data indicate that normal variations within the sequence of apoptotic genes may lead to suboptimal apoptotic capacity and therefore increased cancer risk. DR4 polymorphisms have been described in different human cancer, such as breast, gastric, bladder, lung cancer and endometriosis (Kuraoka Ulybina et al, 2009;Kim et al, 2012). Polymorphism in the ectodomain of DR4 C626G (rs4871857), A683C (rs17088993) and A1322G (rs2230229) were found in a higher frequency in primary tumors of different origin as compared to matched controls (Fisher et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Association of DR4 (TRAIL-R1) Polymorphisms with Cancer Risk in Caucasians: an Updated Meta-analysis

Chen

Tang²,

Zhang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Coding polymorphisms in Casp5, Casp8 and DR4 genes may play a role in predisposition to lung cancer

Cited by 36 publications

References 30 publications

HuGE systematic review and meta-analysis demonstrate association of CASP-3 and CASP-7 genetic polymorphisms with cancer risk

HuGE systematic review and meta-analysis demonstrate association of CASP-3 and CASP-7 genetic polymorphisms with cancer risk

Role of CASP-10 gene polymorphisms in cancer susceptibility: a HuGE review and meta-analysis

Association of DR4 (TRAIL-R1) Polymorphisms with Cancer Risk in Caucasians: an Updated Meta-analysis

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