Codium fragile Ameliorates High-Fat Diet-Induced Metabolism by Modulating the Gut Microbiota in Mice

Kim, Jungman; Choi, Jae Ho; Oh, Tae-Kwang; Ahn, Byung-Jae; Unno, Tatsuya

doi:10.3390/nu12061848

Cited by 34 publications

(25 citation statements)

References 73 publications

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“…Interestingly, the health effects and gut microbiota modulation were similar by FUC derived from Laminaria japonica and Undaria pinnatifida (Chen et al., 2019; Liu et al., 2018; Shang, Song et al., 2017). The same was also observed in Codium fragile and its SPs, that is, both Codium fragile and its SPs prevented obesity and modified the disturbance of the gut microbiota induced by HFD (Kim et al., 2020; Kolsi et al., 2017). These findings suggested that SPs in seafoods were at least partially responsible for the gut microbiota modulation and associated health effects of whole seafoods.…”

Section: Health Effects Of Sps Versus Whole Seafoods On Microbiota‐related Functionsmentioning

confidence: 59%

Health effects of dietary sulfated polysaccharides from seafoods and their interaction with gut microbiota

Zhu

Han

Ding

et al. 2021

Comp Rev Food Sci Food Safe

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Various dietary sulfated polysaccharides (SPs) have been isolated from seafoods, including edible seaweeds and marine animals, and their health effects such as antiobesity and anti‐inflammatory activities have attracted remarkable interest. Sulfate groups have been shown to play important roles in the bioactivities of these polysaccharides. Recent in vitro and in vivo studies have suggested that the biological effects of dietary SPs are associated with the modulation of the gut microbiota. Dietary SPs could regulate the gut microbiota structure and, accordingly, affect the production of bioactive microbial metabolites. Because of their differential chemical structures, dietary SPs may specifically affect the growth of certain gut microbiota and associated metabolite production, which may contribute to variable health effects. This review summarizes the latest findings on the types and structural characteristics of SPs, the effects of different processing techniques on the structural characteristics and health effects of SPs, and the current understanding of the role of gut microbiota in the health effects of SPs. These findings might help in better understanding the mechanism of the health effects of SPs and provide a scientific basis for their application as functional food.

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Section: Health Effects Of Sps Versus Whole Seafoods On Microbiota‐related Functionsmentioning

confidence: 59%

Health effects of dietary sulfated polysaccharides from seafoods and their interaction with gut microbiota

Zhu

Han

Ding

et al. 2021

Comp Rev Food Sci Food Safe

View full text Add to dashboard Cite

show abstract

“…However, it is known that H. pylori -induced alterations in the composition of the intestinal microbiota are due to changes in the lifestyle and diet patterns of H. pylori -infected individuals [ 20 ]. In addition, as discussed below, H. pylori infection leads to a reduction in Lactobacillus , Lachnospiraceae , and Blautia , bacteria that have also been found to be reduced in metabolic diseases such as obesity, metabolic syndrome, and diabetes [ 68 , 69 , 70 ]. Thus, altered intestinal microbiota may lead to disease.…”

Section: The Impact Of Diet Patterns In Helicobacter Pylori Infectionmentioning

confidence: 99%

Impact of Dietary Patterns on H. pylori Infection and the Modulation of Microbiota to Counteract Its Effect. A Narrative Review

et al. 2021

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Helicobacter pylori (H. pylori) is a Gram-negative bacterium that colonizes the stomach and can induce gastric disease and intra-gastric lesions, including chronic gastritis, peptic ulcers, gastric adenocarcinoma, and mucosa-associated lymphoid tissue lymphoma. This bacterium is responsible for long-term complications of gastric disease. The conjunction of host genetics, immune response, bacterial virulence expression, diet, micronutrient availability, and microbiome structure influence the disease outcomes related to chronic H. pylori infection. In this regard, the consumption of unhealthy and unbalanced diets can induce microbial dysbiosis, which infection with H. pylori may contribute to. However, to date, clinical trials have reported controversial results and current knowledge in this field is inconclusive. Here, we review preclinical studies concerning the changes produced in the microbiota that may be related to H. pylori infection, as well as the involvement of diet. We summarize and discuss the last approaches based on the modulation of the microbiota to improve the negative impact of H. pylori infection and their potential translation from bench to bedside.

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“…However, there is little evidence indicating an effect of β‐carotene on UC protection. To investigate the alpha diversity in each sample, the Chao1 estimator (Chao, 1984; Chao & Yang, 1993; Gong et al, 2020), the observed species indices, the Shannon diversity indices (Kim et al, 2020; Shannon, 1948) and the Simpson indices (Simpson, 1949; Yang et al, 2019) were measured. There were no significant differences in these four indexes between groups (Table 2).…”

Section: Resultsmentioning

confidence: 99%

Gut microbiota regulation and anti‐inflammatory effect of β‐carotene in dextran sulfate sodium‐stimulated ulcerative colitis in rats

Zhu

Song

Liu

et al. 2021

Journal of Food Science

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β-Carotene displays antioxidant and anti-inflammatory activities and prevents the development of cancer. Ulcerative colitis (UC) is a kind of inflammatory bowel disease that is accompanied by a certain risk of colon cancer. However, the role of β-carotene in the modulation of gut microbiota and UC improvement is unclear. In this research, the properties of β-carotene on anti-inflammatory and the composition of gut microbiota were evaluated in a rat model of UC induced by dextran sulfate sodium (DSS). The results revealed that β-carotene significantly (p < 0.05) decreased the severity of colitis in rats, as assessed using body weight (6.00 ± 1.73%), colon length (22.23 ± 0.53%), and disease activity index, and improved the structure of the colon damaged. Moreover, colonic levels of proinflammatory cytokines were significantly lower following β-carotene supplementation. β-Carotene intervention also lowered the expression levels of phosphorylated p65 (0.60 ± 0.02), p38 (0.57 ± 0.00), Erk (0.63 ± 0.04), and JNK (0.70 ± 0.00). The result of the relative abundance of gut microbiota showed that DSS administration significantly changed the microbial structure at the phylum and genus levels of rats. Furthermore, β-carotene treatment significantly increased the abundance of Faecalibacterium, the levels of which negatively correlated with the levels of inflammatory cytokines. Faecalibacterium may be a potential target in the alleviation of DSS-induced UC. β-Carotene can alleviate DSS-induced UC through the regulation of gut microbiota. This study provides a reference for the rational use of β-carotene in the treatment of UC.Practical Application: β-Carotene can relieve ulcerative colitis and regulate the gut microbiota; the nutritional intervention of β-carotene enhancing animal health.

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Codium fragile Ameliorates High-Fat Diet-Induced Metabolism by Modulating the Gut Microbiota in Mice

Cited by 34 publications

References 73 publications

Health effects of dietary sulfated polysaccharides from seafoods and their interaction with gut microbiota

Health effects of dietary sulfated polysaccharides from seafoods and their interaction with gut microbiota

Impact of Dietary Patterns on H. pylori Infection and the Modulation of Microbiota to Counteract Its Effect. A Narrative Review

Gut microbiota regulation and anti‐inflammatory effect of β‐carotene in dextran sulfate sodium‐stimulated ulcerative colitis in rats

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