Impact of Dietary Patterns on H. pylori Infection and the Modulation of Microbiota to Counteract Its Effect. A Narrative Review

Abstract

Helicobacter pylori (H. pylori) is a Gram-negative bacterium that colonizes the stomach and can induce gastric disease and intra-gastric lesions, including chronic gastritis, peptic ulcers, gastric adenocarcinoma, and mucosa-associated lymphoid tissue lymphoma. This bacterium is responsible for long-term complications of gastric disease. The conjunction of host genetics, immune response, bacterial virulence expression, diet, micronutrient availability, and microbiome structure influence the disease outcomes related to chronic H. pylori infection. In this regard, the consumption of unhealthy and unbalanced diets can induce microbial dysbiosis, which infection with H. pylori may contribute to. However, to date, clinical trials have reported controversial results and current knowledge in this field is inconclusive. Here, we review preclinical studies concerning the changes produced in the microbiota that may be related to H. pylori infection, as well as the involvement of diet. We summarize and discuss the last approaches based on the modulation of the microbiota to improve the negative impact of H. pylori infection and their potential translation from bench to bedside.

Spatial-temporal Distribution and Influencing Factors of Helicobacter pylori Infection in Chinese Mainland, 2001-2020

“…Similar to our findings, a large-scale cross-sectional survey found that a diet characterized by a large intake of animal viscera, animal blood, fish, seafood, and poultry was associated with a reduction in the rate of H. pylori infection 25. Many substances ingested in the diet have strong antibacterial activity against H. pylori and change the gastric environment through the nutritional intake of the host, which may reduce the possibility of its colonization 26…”

“…25 Many substances ingested in the diet have strong antibacterial activity against H. pylori and change the gastric environment through the nutritional intake of the host, which may reduce the possibility of its colonization. 26 The prevalence of H. pylori in China was the highest in the west, followed by the eastern coastal regions, and the lowest in the central region. The spatial trend analysis module was used to draw the disease trend map in 3-dimensional space to reflect the overall changes of the disease in latitude and longitude.…”

Study of the Effect of Baicalin from Scutellaria baicalensis on the Gastrointestinal Tract Normoflora and Helicobacter pylori

“…It is known that the mechanism of action of a number of probiotic strains on H. pylori is due to the production of peptides and non-peptide substances that inhibit the growth and adhesion of the pathogenic strain [5,17,18]. Probiotics are known to inhibit H. pylori attachment to human gastric epithelial cell lines, suppress the inflammatory processes associated with this infection, and inhibit the growth of antibiotic-resistant H. pylori [19]. The probiotic microorganisms release antibacterial compounds and shortchain fatty acids, which inhibit the growth of H. pylori bacteria.…”

Spice Intake Among Chronic Gastritis Patients and Its Relationship With Blood Lipid Levels in South India

“…Chronic H. pylori infection-related disease outcomes are influenced by the interaction of host genetics, immunological response, bacterial virulence expression, diet, availability of micronutrients, and microbiome structure. The burden of CG is therefore compounded due to poor diets [4]. usually present with abdominal pain in the epigastric region which might mostly be accompanied by a burning sensation and loss of appetite.…”

“…Chronic H. pylori infection-related disease outcomes are influenced by the interaction of host genetics, immunological response, bacterial virulence expression, diet, availability of micronutrients, and microbiome structure. The burden of CG is therefore compounded due to poor diets [ 4 ].…”