Coeliac disease: A critical review of aetiology and pathogenesis

Davidson, A. G. F.; Bridges, Michael A.

doi:10.1016/0009-8981(87)90031-3

Cited by 46 publications

(6 citation statements)

References 215 publications

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“…Coeliac disease (gluten-sensitive enteropathy) is characterized by a reaction of hypersensitivity of the small intestine in genetically susceptible individuals after the ingestion of gluten proteins of either flour or meal from wheat, rye, barl¢y and possibly oat [7,8]. Recently some progress on the causative agents has been made, and the alcohol-soluble proteins of the gluten fraction, collectively known as prolamins, and termed hordeins (barley), gliadins (wheat) and scoalins (rye) have been reported as being responsible for the toxicity known to cause coeliac disease symptoms [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Identification of the three major coeliac immunoreactive proteins and one α‐amylase inhibitor from oat endosperm

et al. 1992

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Six chloroform/mcthanol-solubl¢ proteins from oat endosperm (Avena saliva) have been isolated and characterized by a purification procedure based on extraction with volatile solvents, followed by reversed-phase high performan~ liquid chromatography. Three of these proteins, with an assessed mol~ular weight of 25,000, 27,000 and 32,000 Da, respectively, have been identified by immunoblotting using ¢oeliac sere, as the major co¢liac serum leA-binding components of oat endosperm. The N-terminal amino acid sequence of these proteins indicates that they correspond to oh., 74, and 7a avenins, respectively. We have tentatively named them 'coeliac immunoreactive proteins'. Another chloroform/methanol oat component shows weak g-amylase inhibitory activity and exhibits strong homology (60% identity) at the N-tgrmin~ with the g-amylase inhibitor from ragi (Eleusilze coracana).

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Section: Introductionmentioning

confidence: 99%

Identification of the three major coeliac immunoreactive proteins and one α‐amylase inhibitor from oat endosperm

et al. 1992

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“…One group, up to 0.5% of the total population, suffers from a clinical form called coeliac disease (CD). CD, one of the best characterized diseases of enterocytes, is a permanent intestinal intolerance to the wheat proteins of the gliadin class and the related proteins of rye, barley and probably oats (68). The idea of research carried out in our laboratory by Allmann et al (24,29) was to detect wheat and other CD toxic cereals by PCR and to qualitatively determine the presence of these cereals in dietary foods for coeliac patients.…”

Section: Wheat In Dietary Foods For Coeliac Patientsmentioning

confidence: 99%

PCR-based DNA Analysis for the Identification and Characterization of Food Components

Meyer

Candrian

1996

LWT - Food Science and Technology

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“…Celiac disease (CD) has been shown to be associated with a number of immunological abnorrnalities (10) and with allospecific HLA class II antigens (11) .…”

Section: Expression Of Class II Mhc Antigens In the Intestinalmentioning

confidence: 99%

Expression of Class II MHC Antigens in the Intestinal Epithelium of Pediatric Celiac Disease

Bonamico,

Mazzilli,

Morellini

et al. 1989

J. pediatr. gastroenterol. nutr.

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Class II MHC antigen expression in the intestinal epithelium of 28 small bowel biopsies from 23 celiac patients were studied by means of indirect immunofluorescence and immunoperoxidase using monoclonal antibodies. Patients were divided on the basis of diet into two subgroups: 15 subjects on a gluten‐containing diet (GCD) and 13 on a gluten‐free diet (GFD). The control group included 10 pediatric subjects with normal intestinal mucosa who underwent intestinal biopsy for chronic diarrhea or short stature. DR antigens and invariant chain were expressed in all patients, regardless of the diet, as well as in the control subjects. DQ was found in one patient only on GCD. DP antigens were present in 12/15 patients on GCD, and in 2/13 on GFD (Fisher's exact test, p = 8.8 x 10‐4), as well as in 3/10 control subjects. In 4/5 celiac patients, DP antigens, which were undetectable on GFD, could be demonstrated after gluten challenge. The results of the study show that DR antigens are expressed by intestinal mucosa of celiac patients independently of their gluten exposure and that DQ antigens are consistently undetectable. Statistically significant differences in expression of DP antigens on enterocytes of celiac patients on GCD and their neoexpression after gluten challenge may represent a basis for further investigation.

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Coeliac disease: A critical review of aetiology and pathogenesis

Cited by 46 publications

References 215 publications

Identification of the three major coeliac immunoreactive proteins and one α‐amylase inhibitor from oat endosperm

Identification of the three major coeliac immunoreactive proteins and one α‐amylase inhibitor from oat endosperm

PCR-based DNA Analysis for the Identification and Characterization of Food Components

Expression of Class II MHC Antigens in the Intestinal Epithelium of Pediatric Celiac Disease

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