Coeliac disease in North Indian children.

Walia, B. N. S.; Sidhu, J. K.; Tandon, B. N.; Op, Ghai; Bhargava, Shashank

doi:10.1136/bmj.2.5524.1233

Cited by 54 publications

(32 citation statements)

References 5 publications

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confidence: 95%

“…However, there are sporadic reports of CD from Arabia (1)(2)(3) and India (4)(5)(6)(7). Celiac disease was reported from India in 1966 (4), and subsequently Nelson et al (8) reported a series of 17 immigrant Asian children with CD from Birmingham. However, there has been doubt recently regarding the existing literature on CD from Asia (5) because diagnoses were based on villous atrophy only (1)(2)(3)(4)6), and in developing countries many conditions other than CD can give rise to severe villous atrophy (7).…”

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confidence: 95%

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Celiac Disease in India: Are They True Cases of Celiac Disease?

Poddar

Thapa

Nain

et al. 2002

Journal of Pediatric Gastroenterology and Nutrition

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confidence: 95%

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confidence: 95%

Celiac Disease in India: Are They True Cases of Celiac Disease?

Poddar

Thapa

Nain

et al. 2002

Journal of Pediatric Gastroenterology and Nutrition

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“…Many studies have used groups of adults as control, some of them without a jejunal biopsy (4,(32)(33)(34)(35)(36). In general, antigliadin IgA has proven to be more specific for celiac disease.…”

Section: Discussionmentioning

confidence: 99%

Serum antigliadin antibody levels as a screening criterion before jejunal biopsy indication for celiac disease in a developing country

Bahia

Rabello²,

Filho

et al. 2001

Braz J Med Biol Res

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The objective of the present study was to determine the efficacy of detection of antigliadin immunoglobulins G and A (IgG and IgA) for the diagnosis of celiac disease in a developing country, since other enteropathies might alter the levels of these antibodies. Three groups were studied: 22 patients with celiac disease (mean age: 30.6 months), 61 patients with other enteropathies (mean age: 43.3 months), and 46 patients without enteropathies (mean age: 96.9 months). Antigliadin IgG and IgA ELISA showed sensitivity of 90.9 and 95.5%, respectively. With the hypothetical values of prevalence ranging from 1:500 to 1:2000 liveborns, the positive predictive value varied from 8.5 to 2.3% for IgG and from 4.8 to 1.1% for IgA. Considering the patients without enteropathies, specificity was 97.8 and 95.7% for IgG and IgA, respectively. In patients with other enteropathies, specificity was 82.0 and 84.1%, respectively. When patients with and without other enteropathies were considered as a whole, specificity was 88.8 and 91.6%, respectively. The specificity of positive IgG or IgA was 93.5% in children without enteropathies and 78.7% in the presence of other enteropathies. The negative predictive value for hypothetical prevalences varying from 1:500 to 1:2000 liveborns was 99.9%. Thus, even in developing countries where the prevalence of non-celiac enteropathies is high, the determination of serum antigliadin antibody levels is a useful screening test prior to the jejunal biopsy in the investigation of intestinal malabsorption.

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“…[2][3][4][5][6]. Although celiac disease was described in India four decades ago, it's only in the last decade that an upward trend in the number of reported cases has occurred [7][8][9][10]. The availability of simple serological tests has made a significant contribution towards earlier and more frequent diagnosis [11].…”

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confidence: 99%

Suboptimal Performance of IgG Anti-tissue Transglutaminase in the Diagnosis of Celiac Disease in a Tropical Country

2009

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Serological tests using human IgA-anti-tTG have been reported to have high sensitivity and specificity in diagnosis of celiac disease. There is a paucity of data on the use of human IgG-anti-tTG in diagnosis of celiac disease. Ninety-two patients with clinical suspicion of celiac disease who underwent duodenal mucosal biopsy and celiac serology using human IgG-anti-tTG were included in this retrospective study. Diagnostic accuracy of human recombinant IgG-anti-tTG serological test for celiac disease was evaluated. Indications for celiac serological testing were diarrhea (92.3%), hypoalbuminemia (39.1%), and anemia (35.9%). Eighteen patients were diagnosed with having celiac disease and 14 (77.8%) of them were IgG-anti-tTG positive. Of the remaining 74 patients, eight (10.8%) were false-positive for IgG-anti-tTG. Sensitivity, specificity, PPV, NPV, and diagnostic accuracy of IgG-anti-tTG in celiac disease were 77.8, 89.1, 63.6, 94.2, and 87%, respectively. Human IgG-anti-tTG alone does not perform well as a diagnostic tool for celiac disease. The utility of anti-endomysial antibodies in a similar clinical setting needs to be evaluated.

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Coeliac disease in North Indian children.

Cited by 54 publications

References 5 publications

Celiac Disease in India: Are They True Cases of Celiac Disease?

Celiac Disease in India: Are They True Cases of Celiac Disease?

Serum antigliadin antibody levels as a screening criterion before jejunal biopsy indication for celiac disease in a developing country

Suboptimal Performance of IgG Anti-tissue Transglutaminase in the Diagnosis of Celiac Disease in a Tropical Country

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