2021
DOI: 10.1016/j.freeradbiomed.2021.01.018
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Coenzyme Q redox signalling and longevity

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Cited by 31 publications
(31 citation statements)
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References 246 publications
(356 reference statements)
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“…Under TS, in young mitochondria ROS-RET is activated in response to increased electron entry through CI/CII and accessory dehydrogenases that are not part of the canonical ETC. This is similar to what has been reported in other scenarios where ROS-RET is triggered [ 38 ]. For example, ROS-RET is usually associated with increased oxidation of succinate by CII, like during ischemia reperfusion [ 6 ] or hypoxia within specialised cells of the carotid body [ 10 ].…”
Section: Discussionsupporting
confidence: 91%
See 1 more Smart Citation
“…Under TS, in young mitochondria ROS-RET is activated in response to increased electron entry through CI/CII and accessory dehydrogenases that are not part of the canonical ETC. This is similar to what has been reported in other scenarios where ROS-RET is triggered [ 38 ]. For example, ROS-RET is usually associated with increased oxidation of succinate by CII, like during ischemia reperfusion [ 6 ] or hypoxia within specialised cells of the carotid body [ 10 ].…”
Section: Discussionsupporting
confidence: 91%
“…During ageing, there is an increase in the generation of mtROS [ 38 ] that will impact redox signalling. Here, we show that young mitochondria increase ROS production in response to specific stimuli such as TS and rotenone, while aged mitochondria continually produce high levels of ROS (Fig.…”
Section: Discussionmentioning
confidence: 99%
“…ROS act as regulatory and signalling molecules and are essential to proper cell function in a system known as REDOX regulation [19], participating in cell division, differentiation, and death. Consequently, OS also produces dysregulation of the redox signalling, and therefore, an alteration in cellular homeostasis [20,21].…”
Section: What Is Oxidative Stress?mentioning
confidence: 99%
“…During ageing we propose that CI ceases to be the main ROS generator and is replaced by one or more generators inactive in young flies. The most likely candidate is CIII which has been shown to increase ROS when CIV is inhibited and has been described as the main generator of ROS in aged rat heart mitochondria [23][24][25]. Further research to confirm or discard this possibility is warranted.…”
Section: Discussionmentioning
confidence: 99%