Coenzyme Q10 distribution in blood is altered in patients with Fibromyalgia

Cordero, Mario D.; Fernández, Antonio J. Sánchez; Miguel, Manuel de; Bonal, Pablo; Campa, Francisco; Jiménez-Jiménez, Luis; Ruiz-Losada, A.; Sánchez-Domínguez, Benito; Sánchez-Alcázar, José Antonio; Salviati, Leonardo; Navas, Plácido

doi:10.1016/j.clinbiochem.2008.12.010

Cited by 61 publications

(46 citation statements)

References 13 publications

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“…Additionally, we have also shown that BMCs can be an excellent model to study the relation between oxidative stress and FM. [8], [15].…”

Section: Discussionmentioning

confidence: 99%

“…Recently, oxidative stress has been proposed as a relevant event in the pathogenesis of this disorder [3]–[6]. Previously, our group has detected decreased coenzyme Q 10 (CoQ 10 ) levels and increased mitochondrial reactive oxygen species (ROS) production in blood mononuclear cells (BMCs) from FM patients [7], [8]. In addition, we have observed that CoQ 10 and α-tocopherol, two lipophilic antioxidants, induced a significant reduction of ROS in BMCs from FM patients.…”

Section: Introductionmentioning

confidence: 99%

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Clinical Symptoms in Fibromyalgia Are Better Associated to Lipid Peroxidation Levels in Blood Mononuclear Cells Rather than in Plasma

et al. 2011

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BackgroundWe examined lipid peroxidation (LPO) in blood mononuclear cells (BMCs) and plasma, as a marker of oxidative damage, and its association to clinical symptoms in Fibromyalgia (FM) patients.MethodsWe conducted a case–control and correlational study comparing 65 patients and 45 healthy controls. Clinical parameters were evaluated using the Fibromyalgia Impact Questionnaire (FIQ), visual analogues scales (VAS), and the Beck Depression Inventory (BDI). Oxidative stress was determined by measuring LPO in BMCs and plasma.ResultsWe found increased LPO levels in BMCs and plasma from FM patients as compared to normal control (P<0.001). A significant correlation between LPO in BMCs and clinical parameters was observed (r = 0.584, P<0.001 for VAS; r = 0.823, P<0.001 for FIQ total score; and r = 0.875, P<0.01 for depression in the BDI). We also found a positive correlation between LPO in plasma and clinical symptoms (r = 0.452, P<0.001 for VAS; r = 0.578, P<0.001 for FIQ total score; and r = 0.579, P<0.001 for depression in the BDI). Partial correlation analysis controlling for age and BMI, and sex, showed that both LPO in cells and plasma were independently associated to clinical symptoms. However, LPO in cells, but not LPO in plasma, was independently associated to clinical symptoms when controlling for depression (BDI scores).DiscussionThe results of this study suggest a role for oxidative stress in the pathophysiology of fibromyalgia and that LPO in BMCs rather than LPO in plasma is better associated to clinical symptoms in FM.

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“…Additionally, we have also shown that BMCs can be an excellent model to study the relation between oxidative stress and FM. [8], [15].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical Symptoms in Fibromyalgia Are Better Associated to Lipid Peroxidation Levels in Blood Mononuclear Cells Rather than in Plasma

et al. 2011

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“…Of interest to rheumatologists, CoQ 10 was increased in plasma but decreased in blood mononuclear cells from patients with fibromyalgia; evidence that CoQ 10 relieved oxidative stress in mononuclear cells was adduced as an indication for the therapeutic use of CoQ 10 in patients with fibromyalgia [34].…”

Section: Mitochondrial Myopathiesmentioning

confidence: 99%

Metabolic Myopathies

2010

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We consider recent developments in disorders affecting three areas of metabolism: glycogen, fatty acids, and the mitochondrial respiratory chain. Among the glycogenoses, new attention has been directed to defects of glycogen synthesis resulting in absence rather than excess of muscle glycogen ("aglycogenosis"). These include defects of glycogen synthetase and defects of glycogenin, the primer of glycogen synthesis. Considerable progress also has been made in our understanding of alterations of glycogen metabolism that result in polyglucosan storage. Among the disorders of lipid metabolism, mutations in the genes encoding two triglyceride lipases acting hand in hand cause severe generalized lipid storage myopathy, one associated with ichthyosis (Chanarin-Dorfman syndrome), the other dominated by juvenile-onset weakness. For the mitochondrial myopathies, we discuss the importance of homoplasmic mitochondrial DNA mutations and review the rapid progress made in our understanding of the coenzyme Q(10) deficiencies, which are often treatable.

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“…To be specific, oxidant/ antioxidant imbalance either as a direct result of excessive reactive oxygen species production or antioxidant deficiency cause periodontal tissue destruction (14) and alveolar bone loss (15,16). Unlike periodontitis, whether oxidative stress is an outcome or a causative factor in FMS is not clear (17)(18)(19)(20).…”

Section: Introductionmentioning

confidence: 99%