Coenzyme Q10 promotes osteoblast proliferation and differentiation and protects against ovariectomy-induced osteoporosis

Zheng, Delu; Cui, Chenli; Yu, Meng; Li, Xiang; Wang, Lu; Chen, Xinyan; Lin, Yi‐Chen

doi:10.3892/mmr.2017.7907

Cited by 24 publications

(24 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies have shown that CoQ10 inhibits osteoclast differentiation by suppressing inflammatory responses, reactive oxygen species generation, and TRAP expression in vitro and in vivo [ 22 , 41 ]. In addition, CoQ10 induces the proliferation and differentiation of osteoblasts [ 42 ]. 4-AAQB might show similar mechanisms of action as CoQ10 in osteoblasts.…”

Section: Discussionmentioning

confidence: 99%

4-Acetylantroquinonol B Inhibits Osteoclastogenesis by Inhibiting the Autophagy Pathway in a Simulated Microgravity Model

Yen

et al. 2020

IJMS

View full text Add to dashboard Cite

Astronauts suffer from 1–2% bone loss per month during space missions. Targeting osteoclast differentiation has been regarded as a promising strategy to prevent osteoporosis in microgravity (μXg). 4-acetylantroquinonol B (4-AAQB), a ubiquinone from Antrodia cinnamomea, has shown anti-inflammatory and anti-hepatoma activities. However, the effect of 4-AAQB on μXg-induced osteoclastogenesis remains unclear. In this study, we aimed to explore the mechanistic impact of 4-AAQB on osteoclast formation under μXg conditions. The monocyte/macrophage-like cell line RAW264.7 was exposed to simulated μXg (Rotary Cell Culture System; Synthecon, Houston, TX, USA) for 24 h and then treated with 4-AAQB or alendronate (ALN) and osteoclast differentiation factor receptor activator of nuclear factor kappa-B ligand (RANKL). Osteoclastogenesis, bone resorption activity, and osteoclast differentiation-related signaling pathways were analyzed using tartrate-resistant acid phosphatase (TRAP) staining, actin ring fluorescent staining, bone resorption, and western blotting assays. Based on the results of TRAP staining, actin ring staining, and bone resorption assays, we found that 4-AAQB significantly inhibited μXg-induced osteoclast differentiation. The critical regulators of osteoclast differentiation, including nuclear factor of activated T-cells cytoplasmic 1 (NFATc1), c-Fos, and dendritic cell-specific transmembrane protein (DC-STAMP), were consistently decreased. Meanwhile, osteoclast apoptosis and cell cycle arrest were also observed along with autophagy suppression. Interestingly, the autophagy inhibitors 3-methyladenine (3-MA) and chloroquine (CQ) showed similar effects to 4-AAQB. In conclusion, we suggest that 4-AAQB may serve as a potential agent against μXg-induced osteoclast formation.

show abstract

Section: Discussionmentioning

confidence: 99%

4-Acetylantroquinonol B Inhibits Osteoclastogenesis by Inhibiting the Autophagy Pathway in a Simulated Microgravity Model

Yen

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

“…In humans, clinical trials suggested that doses up to 3000 mg/day of CoQ10 did not cause serious adverse effects except for nausea and other minor adverse gastrointestinal effects. CoQ10 was found to be effective against osteoporosis (28,29). Zhang et al (28) showed CoQ10 to be effective in attenuating spinal cord injury induced osteoporosis.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Systemic Administration of Co-enzyme Q10 on Orthodontic Relapse in a rabbit model

Madian

Abdallah

Harouni

et al. 2021

Alexandria Dental Journal

View full text Add to dashboard Cite

INTRODUCTION: Several pharmacological agents have been investigated for their ability to reduce orthodontic relapse. OBJECTIVE: The current research was performed to test the short term influence of systemic Co-enzyme Q10 administration on post-orthodontic relapse in rabbits. MATERIALS AND METHODS : Thirty New Zealand rabbits were randomly divided into 2 groups (n=15) : Experimental receiving Co-enzyme Q10 and control receiving control vehicle. Orthodontic tooth movement was performed using NiTi coil spring for 21 days for both groups, then this coil spring was detached, and teeth were allowed to relapse for another 21 days. Amounts and percentages of relapse were assessed on threedimensional models of the experimental and control groups at two time points (T2: 1 week of relapse) and (T3: three weeks of relapse). Animals were sacrificed after 3 weeks of relapse for histological examination using H&E stain. Also, histomorphometric analysis was performed. Statistical analysis was computed. Significance was judged at the 5% level. RESULTS: The amount and percentage of relapse showed insignificant difference among experimental and control groups, although relapse in the experimental group was less. However, the histological analysis showed that Co-enzyme Q10 resulted in significant reduction in osteoclast count with the area of new bone formation being significantly increased. Signs of bone resorption were more evident in the control group. CONCLUSION: From the present results, it could be concluded that Co-enzyme Q10 is capable of altering bone resorption pattern favorably in spite of its short term ineffectiveness in minimizing relapse.

show abstract

“…PtdIns(3,4,5)P3 can up-regulate the phosphorylation of Akt to phosphorylate numerous substrates regulating various cellular processes. PLEKHA1 is notably associated with the signaling pathway of PI3K/Akt, which plays an important role in osteoporosis [65,66]. Based on a mouse model, deletion of PtdIns (3,4,5)P 3 in the brain results in impaired bone mass and mineralization [67] and down-regulated PtdIns(3,4,5)P 3 levels also affected osteoclast activity and BMD [68].…”

Section: Discussionmentioning

confidence: 99%

Identification of novel variants associated with osteoporosis, type 2 diabetes and potentially pleiotropic loci using pleiotropic cFDR method

Tan

Chen

et al. 2018

Bone

View full text Add to dashboard Cite

show abstract

Coenzyme Q10 promotes osteoblast proliferation and differentiation and protects against ovariectomy-induced osteoporosis

Cited by 24 publications

References 38 publications

4-Acetylantroquinonol B Inhibits Osteoclastogenesis by Inhibiting the Autophagy Pathway in a Simulated Microgravity Model

4-Acetylantroquinonol B Inhibits Osteoclastogenesis by Inhibiting the Autophagy Pathway in a Simulated Microgravity Model

The Effect of Systemic Administration of Co-enzyme Q10 on Orthodontic Relapse in a rabbit model

Identification of novel variants associated with osteoporosis, type 2 diabetes and potentially pleiotropic loci using pleiotropic cFDR method

Contact Info

Product

Resources

About