Coenzyme Q10 supplementation ameliorates inflammatory signaling and oxidative stress associated with strenuous exercise

Abstract

CoQ(10) supplementation before strenuous exercise decreases the oxidative stress and modulates the inflammatory signaling, reducing the subsequent muscle damage.

The effects of coenzyme Q10 administration on glucose homeostasis parameters, lipid profiles, biomarkers of inflammation and oxidative stress in patients with metabolic syndrome

“…However, after adjustment for the baseline levels, age and baseline BMI, the effect on TAC levels disappeared. Diaz-Castro et al [29] demonstrated a significant increase in the total antioxidant status (TAS) levels following the supplementation of CoQ10 before strenuous exercise among a group of amateur athletes. A significant increase in TAC levels was also observed after daily intake of 100 mg CoQ10 supplements after 12 weeks in varicocele patients [30].…”

Exercise and oxidative stress: Potential effects of antioxidant dietary strategies in sports

“…The daily intake of CoQ10 was estimated to be 3-5 mg [43]. Recent data suggests that oral supplementation of Co-enzyme Q10 during highintensity exercise reduces oxidative stress, and creatinine excretion [44]. Conversely, 8 weeks of treatment with a daily dose of 90 mg of Q10 in moderately trained subjects did not affect exercise capacity and oxidative stress [45].…”

Potential role of coenzyme Q₁₀ in health and disease conditions

“…However, the supplemented CG did not demonstrate increases in oxidative stress markers and witnessed a spike in catalase activity, an indication of antioxidant enhancement. 55 These results provide a rationale for further insight into the mechanism by which CoQ 10 ameliorates ROS damage.…”

“…55 Conversely, increased intensity and duration can result in episodes of fatigue and muscle injury due to ROS produced during an exercise session. As a scavenging antioxidant, it has been theorized that CoQ 10 supplementation before exercise could protect muscle cells and subsequently improve the aspects of physical performance.…”

“…The concern is that damage to muscle cells in this type of workout can act as a catalyst for progressive oxidative stress and inflammation in the muscle. Díaz-Castro et al 55 compared two groups composed of high-effort runners to distinguish any possible changes in inflammatory and oxidative stress markers after CoQ 10 administration. The CoQ group (CG) received five capsules of 30 mg CoQ 10 tablets beginning 2 days before the trial, with one capsule taken at every meal leading up to the trial day.…”