Coenzyme Q10 treatment of cardiovascular disorders of ageing including heart failure, hypertension and endothelial dysfunction

Yang, Ye; Wang, Linping; Chen, Lei; Xiu-ping, Yao; Yang, Kun; Gao, Linggen; Zhou, Xin

doi:10.1016/j.cca.2015.08.002

Cited by 69 publications

(53 citation statements)

References 73 publications

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“…They found that sunflower oil had mainly CoQ9 with 101.3 mg/kg and only 8.7 mg/kg of CoQ10 in refined oil whereas other studies showed higher amounts of CoQ10 up to 15 mg/kg in crude oil (Pregnolato et al, 1994). These coenzymes are interesting because they have antioxidant and anti-inflammatory activities (Yang et al, 2015).…”

Section: Coenzymes Q9 and Q10mentioning

confidence: 99%

Effects of refining process on sunflower oil minor components: a review

Gotor

Rhazi

2016

OCL

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-Sunflower oil is well known because of its diversity of fatty acids profiles which allow different uses (food: dressing salads, margarines; nonfood: agrofuel, lubricants). Besides, crude oil contains high amounts of desirable minor components (tocopherols, phytosterols, polyphenols, phospholipids. . . ) that present important nutritional features with a positive impact on human health. The different steps of the refining process have as main objective to remove contaminants and other compounds that could hamper the continuity of the process or alter oil during storage. An indirect consequence of this treatment used to preserve food safety is that micronutriments of interest are also partially eliminated reducing the nutritional quality of the oil. This review describes in the first part the chemical composition of sunflower oil focusing on desirable and undesirable components. In the second part the refining process is detailed following the losses of micronutriments at each step of the process and the elimination of unwanted compounds. Keywords:Sunflower oil / minor components / tocopherols / sterols / refining Résumé -Effets du procédé de raffinage sur les composants mineurs de l'huile de tournesol : revue. L'huile de tournesol est bien connue pour la diversité de ses profils d'acides gras qui permettent des usages variés (alimentaireshuile de table et margarines -ou non alimentaires -agrocarburants et lubrifiants). En outre, l'huile brute contient aussi de grandes quantités de composés mineurs souhaitables (tocophérols, phytostérols, polyphénols, phospholipides. . . ) aux caractéristiques nutritionnelles importantes et à impact positif sur la santé humaine. Les différentes étapes du raffinage ont pour principal objectif d'éliminer les contaminants et les composants susceptibles d'entraver la suite du process ou de provoquer une altération de l'huile au stockage. La conséquence indirecte de ce traitement destiné à préserver la sécurité alimentaire est que les micronutriments d'intérêt sont partiellement éliminés réduisant ainsi la qualité nutritionnelle de l'huile. Dans une première partie, cette revue décrit la composition chimique de l'huile de tournesol en distinguant les composés recherchés et indésirables. La seconde partie examine le procédé de raffinage en suivant les pertes de micronutriments à chaque étape du procès ainsi que l'élimination des produits indésirables.

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Section: Coenzymes Q9 and Q10mentioning

confidence: 99%

Effects of refining process on sunflower oil minor components: a review

Gotor

Rhazi

2016

OCL

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“…The suggested antihypertensive and antiatherosclerotic mechanism of action may be related to its antioxidant properties. While oxidative stress reduces nitric oxide availability resulting in vasoconstriction that leads to an elevated blood pressure, CoQ10 supplementation may result in nitric oxide preservation (Y.-K. Yang et al, 2015). As for atherosclerosis, CoQ10 antioxidant activity may reduce LDL peroxidation and endothelial dysfunction, which is considered to be an early marker for atherosclerosis (Gao et al, 2012;Witting, Pettersson, Letters, & Stocker, 2000).…”

Section: Cardiovascular Diseasesmentioning

confidence: 99%

Coenzyme Q10 supplementation: Efficacy, safety, and formulation challenges

Arenas-Jal

Suñé-Negre

García-Montoya

2020

Comp Rev Food Sci Food Safe

142

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World population growth and aging are posing unprecedented challenges in sustaining the health of 9.1 billion people that will be occupying the planet by 2050. Although noncommunicable diseases such as cardiovascular and neurodegenerative diseases, cancer, and diabetes are among the top 10 global causes of death, they can be prevented by risk factor reduction, early detection, and adequate treatment. Since a healthy diet along with dietary supplementation could play an important role to reduce morbidity and cut off its associated health care costs, research in the food and nutrition area is required to find solutions to global challenges affecting health. As a result of the healthy living trend, dietary supplements category is growing fast, leading to an urgent need for dietitians, physicians, and policy makers to broaden the scientific evidence on the efficacy and safety of a wide range of active ingredients. Coenzyme Q10 (CoQ10), as the third most consumed dietary supplement, and as a potential candidate for the treatment of various noncommunicable diseases that are among the global top 10 causes of death, has gained interest over years. Scientific evidence regarding mainly CoQ10 efficacy and safety, as well as formulation challenges, is addressed in this review.

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“…Ubiquinol-10 (UqH-10), the fully reduced form of Uq-10, acts as an antioxidant within biological membranes and in the mitochondria by either scavenging free radicals directly or by recycling other antioxidants, like α-tocopherol and ascorbate [1,2]. Due to these beneficial roles, Uq-10 and UqH-10 are used to treat a variety of disorders, including cardiovascular syndromes and primary CoQ 10 -deficiency syndrome, and is available over the counter as a dietary supplement worldwide [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Novel Cationic Prodrug of Ubiquinol-10 Enhances Intestinal Absorption via Efficient Formation of Nanosized Mixed-Micelles with Bile Acid Anions

et al. 2020

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The aim of this study was to develop a prodrug of ubiquinol-10 (UqH-10), the active form of ubiquinone-10 (Uq-10), for oral delivery. Bioavailability of UqH-10 is hampered by its high susceptibility to oxidation and water-insolubility. We prepared three novel N,N-dimethylglycine ester derivatives of UqH-10, including a 1-monoester (UqH-1-DMG), 4-monoester (UqH-4-DMG), and 1,4-bis-ester (UqH-DMG), and assessed their physicochemical properties in vitro and in vivo. UqH-DMG spontaneously formed an aqueous micelle solution comprising 20 nm particles at 36.5 °C. Cationic UqH-DMG formed nano-sized (5 nm) mixed-micelles with taurocholic acid. Reconversion of the derivatives to UqH-10 was accelerated in human liver microsomes. The oral bioavailability of UqH-10 after administration of UqH-derivatives or Uq-10 was determined in fasted and postprandial rats secreting normal and high levels of bile, respectively. In fasted rats, plasma UqH-10 after UqH-derivatives administration reached Cmax at 2–3 h and after Uq-10 administration, it remained low. The AUC0-24h of UqH-10 after UqH-derivatives administration was 2–3-fold higher than that after Uq-10 administration. In postprandial rats, the Tmax of UqH-10 after UqH-derivatives administration was an hour earlier than after Uq-10 administration. In conclusion, cationic UqH-derivatives are convenient prodrugs that enhance UqH-10 bioavailability by forming nanosized mixed-micelles with intestinal bile acids.

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Coenzyme Q10 treatment of cardiovascular disorders of ageing including heart failure, hypertension and endothelial dysfunction

Cited by 69 publications

References 73 publications

Effects of refining process on sunflower oil minor components: a review

Effects of refining process on sunflower oil minor components: a review

Coenzyme Q10 supplementation: Efficacy, safety, and formulation challenges

Novel Cationic Prodrug of Ubiquinol-10 Enhances Intestinal Absorption via Efficient Formation of Nanosized Mixed-Micelles with Bile Acid Anions

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