Coevolution of telomerase activity and body mass in mammals: From mice to beavers

Gorbunova, Vera; Seluanov, Andrei

doi:10.1016/j.mad.2008.02.008

Cited by 103 publications

(98 citation statements)

References 86 publications

(118 reference statements)

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“…In contrast, in the smaller and much shorter-lived mice telomerase is expressed in several somatic tissues, for instance the liver, and the telomeres are not shortened with cell division. These striking differences among the two determinately growing mammals were explained by disparities in life history and body mass (Gorbunova and Seluanov 2009). Animals with indeterminate growth are thought to express telomerase in their tissues also in the adult stages as was shown for the rainbow trout Oncorhynchus mykiss and the American lobster Homarus americanus (Klapper et al 1998).…”

Section: Reproductive and Mechanical Senescencementioning

confidence: 89%

“…For instance, mice express telomerase in some somatic tissues and mole rats show negligible senescence despite determinate growth (Buffenstein 2008;Gorbunova and Seluanov 2009). And the water flea Daphnia magna shows reproductive and tissular senescence in its final period of life despite indeterminate growth (Schulze-Röbbecke 1951).…”

Section: Suitability Of the Marbled Crayfish For Research On Genetic mentioning

confidence: 99%

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Suitability of the clonal marbled crayfish for biogerontological research: a review and perspective, with remarks on some further crustaceans

Vogt

2010

Biogerontology

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This article examines the suitability of the parthenogenetic marbled crayfish for research on ageing and longevity. The marbled crayfish is an emerging laboratory model for development, epigenetics and toxicology that produces up to 400 genetically identical siblings per batch. It is easily cultured, has an adult size of 4-9 cm, a generation time of 6-7 months and a life span of 2-3 years. Experimental data and biological peculiarities like isogenicity, direct development, indeterminate growth, high regeneration capacity and negligible senescence suggest that the marbled crayfish is particularly suitable to investigate the dependency of ageing and longevity from non-genetic factors such as stochastic developmental variation, allocation of metabolic resources, damage and repair, caloric restriction and social stress. It is also well applicable to examine alterations of the epigenetic code with increasing age and to identify mechanisms that keep stem cells active until old age. As a representative of the sparsely investigated crustaceans and of animals with indeterminate growth and extended brood care the marbled crayfish may even contribute to evolutionary theories of ageing and longevity. Some relatives are recommended as substitutes for investigation of topics, for which the marbled crayfish is less suitable like genetics of ageing and achievement of life spans of decades under conditions of low food and low temperature. Research on ageing in the marbled crayfish and its relatives is of practical relevance for crustacean fisheries and aquaculture and may offer starting points for the development of novel anti-ageing interventions in humans.

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Section: Reproductive and Mechanical Senescencementioning

confidence: 89%

Section: Suitability Of the Marbled Crayfish For Research On Genetic mentioning

confidence: 99%

Suitability of the clonal marbled crayfish for biogerontological research: a review and perspective, with remarks on some further crustaceans

Vogt

2010

Biogerontology

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“…Early studies suggested that even among mammals there are significant differences in telomerase levels in adult tissues (Gomes et al, 2010;Greenberg et al, 1998;Prowse & Greider, 1995). In rodents telomerase activity inversely correlates with body mass (Gorbunova & Seluanov, 2009). Recently, an exhaustive analysis of telomerase activity and telomere length in mammals has been reported (Gomes et al, 2011).…”

Section: Telomerase Regulation In Different Speciesmentioning

confidence: 99%

The Regulation of Telomerase by Alternative Splicing of TERT

Nehyba¹,

Hrdličková²,

Bose³

2012

Reviews on Selected Topics of Telomere Biology

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“…However, the target sizes of murine SC pools for mutations in most tissues are likely manifoldly smaller than their human counterparts due to body size. Various mechanisms have been proposed to suppress cancer incidence in larger mammals (22)(23)(24), such as the possible evolution of multiple copies of tumor suppressor genes or suppression of telomerase activity with the evolution of larger body size. These mechanisms could help explain Peto's paradox, whereby larger mammals having much larger SC pool sizes do not develop proportionally more cancers.…”

mentioning

confidence: 99%

Toward an evolutionary model of cancer: Considering the mechanisms that govern the fate of somatic mutations

Rozhok

DeGregori

2015

Proc. Natl. Acad. Sci. U.S.A.

105

101

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Our understanding of cancer has greatly advanced since Nordling [Nordling CO (1953) Br J Cancer 7(1):68-72] and Armitage and Doll [Armitage P, Doll R (1954) Br J Cancer 8(1):1-12] put forth the multistage model of carcinogenesis. However, a number of observations remain poorly understood from the standpoint of this paradigm in its contemporary state. These observations include the similar age-dependent exponential rise in incidence of cancers originating from stem/progenitor pools differing drastically in size, age-dependent cell division profiles, and compartmentalization. This common incidence pattern is characteristic of cancers requiring different numbers of oncogenic mutations, and it scales to very divergent life spans of mammalian species. Also, bigger mammals with larger underlying stem cell pools are not proportionally more prone to cancer, an observation known as Peto's paradox. Here, we present a number of factors beyond the occurrence of oncogenic mutations that are unaccounted for in the current model of cancer development but should have significant impacts on cancer incidence. Furthermore, we propose a revision of the current understanding for how oncogenic and other functional somatic mutations affect cellular fitness. We present evidence, substantiated by evolutionary theory, demonstrating that fitness is a dynamic environment-dependent property of a phenotype and that oncogenic mutations should have vastly different fitness effects on somatic cells dependent on the tissue microenvironment in an age-dependent manner. Combined, this evidence provides a firm basis for understanding the age-dependent incidence of cancers as driven by age-altered systemic processes regulated above the cell level. somatic evolution | cancer | aging | oncogenic mutations | fitness C ancer is believed to develop as a multistage disease driven by oncogenic mutations (also called driver mutations) that occur in stem cells (SCs) or progenitor cells. Each such mutation is thought to confer to the recipient cell a certain fitness advantage over other cells in a competitive stem/progenitor pool, leading to proliferation of the cell's progeny (clone) in the pool. The successive clonal expansions driven by oncogenic mutations multiply the number of cells representing an oncogenic mutation-bearing clone, and thus increase the odds of the occurrence of the subsequent driver mutations in the premalignant genetic background. In this way, carcinogenesis is viewed as a Darwinian process of successive rounds of selection leading to the formation of a malignant cell phenotype produced by a certain number of driver mutations (1-7). SC fitness, being the ability of a SC of a particular genotype/epigenotype to be maintained, expand, or contract within the SC compartment, is thus a central phenomenon determining somatic evolution. Because cancer incidence increases exponentially with age, successive clonal expansions are thought to follow the occurrence of oncogenic mutations and increase the likelihood of subsequent drivers over time, su...

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Coevolution of telomerase activity and body mass in mammals: From mice to beavers

Cited by 103 publications

References 86 publications

Suitability of the clonal marbled crayfish for biogerontological research: a review and perspective, with remarks on some further crustaceans

Suitability of the clonal marbled crayfish for biogerontological research: a review and perspective, with remarks on some further crustaceans

The Regulation of Telomerase by Alternative Splicing of TERT

Toward an evolutionary model of cancer: Considering the mechanisms that govern the fate of somatic mutations

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