Coexistence of anti-Jo1 and anti-signal recognition particle antibodies in a polymyositis patient

Madrid, Enrique Melguizo; Riejos, Patricia Fernández; Miera, F. J. Toyos Sáenz de; Pérez, Berta Fernández; Rodríguez, Concepción González

doi:10.1016/j.reumae.2019.02.003

Cited by 2 publications

(2 citation statements)

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“…Our results did not go against the notion that the presence of MSAs was essentially mutually exclusive in IIM [ 13 ]. The coexistence of two MSAs in an IIM patient is rare but does exist [ 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

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Coexistence of Multiple Myositis-Specific Antibodies in Patients with Idiopathic Inflammatory Myopathies

Huang

Lin

Tsai

et al. 2022

JCM

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The mutual exclusivity of myositis-specific antibodies (MSAs) has been reported before, but the coexistence of 2 or more MSAs was still found in a few case reports. This study aims to confirm the existence and prevalence of double MSAs in patients with idiopathic inflammatory myopathy (IIM) and to clarify the clinical features of these patients. One hundred fifty-one patients with IIM diagnosed from 1 July 2018 to 31 July 2022, at National Cheng Kung University Hospital, Taiwan, were enrolled and divided into two groups, patients with ≤1 MSA (n = 128, 84.8%) and those with ≥2 MSAs (n = 23, 15.2%) according to the initial serology results. After being re-examined by ANA-IIF assay, 8 out of 23 patients were confirmed to have ≥2 MSAs. The demographic data and clinical features were presented. The prevalence of double-positive MSAs among IIM was 5.3% in this cohort. The coexistence of two MSAs in an IIM patient does exist but is rare. Patients with two MSAs belonging to two distinct IIM subtypes presented clinical features skewed to one subtype instead of “mixed phenotypes”. No apparent difference in clinical severity was found between patients with ≥2 MSAs and ≤1 MSA. Longer follow-ups and more studies are required to characterize the patients of IIM with ≥2 MSAs.

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Section: Discussionmentioning

confidence: 99%

“…The mutual exclusivity of MSAs has been reported before [ 13 ], which made the serology tests for MSAs more crucial for IIM subtyping. However, the coexistence of 2 or more MSAs was still found in a few case reports [ 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%