Coexistence of calcitonin gene-related peptide and substance P-like peptide in single cells of the trigeminal ganglion of the rat: immunohistochemical analysis

Effect of Calcitonin Gene-Related Peptide on the Cyclic AMP Level of Isolated Mouse Diaphragm

“…CGRP has been shown to cause physiological responses (4)(5)(6)(7)(8)(9) and to have a binding site (10,11), suggesting that it is a neurotransmitter or neuromodulator. We observed a very wide distribution of CGRP in the central and peripheral nervous systems (3,(12)(13)(14).…”

Vasodilatation by calcitonin gene-related peptide and by substance P: a comparison of their effects on resistance and capacitance vessels of human forearms.

“…Others have shown that during systemic infusion of SP in dogs and in man the maximum effect is achieved rapidly, followed by a gradual decline in the degree of hypotension and tachycardia.13 17 34 Coexistence of the two peptides has also been shown in cell bodies in the dorsal root ganglia and nodose ganglia.32 Nerve fibers positive for both peptides are seen in the celiac, superior cervical myenteric, and autonomic ganglia.5 A similar distribution of nerve fiber networks containing each peptide has been demonstrated in the walls of rodent blood vessels8 and the colocalization of CGRP and SP in the perivascular nerve networks has been confirmed in the cerebral arteries of the rat by double-staining techniques.10 The fibers that contain CGRP and SP are largely from primary sensory afferent nerves, since they are sensitive to capsaicin, a neurotoxin selective for C and AS fibers.8 A few fibers appear more resistant to the neurotoxin and, although this may be a dose-dependent phenomenon, it could also suggest the presence of CGRP in fibers subserving different functions.…”

Cerebellar distribution of calcitonin gene-related peptide (CGRP) and its receptor components calcitonin receptor-like receptor (CLR) and receptor activity modifying protein 1 (RAMP1) in rat

“…Early immunohistochemical studies have demonstrated CGRP in the cerebellum , Lee, et al, 1985. The CGRP immunoreactivity was localized in the Purkinje cell and in its elaborated dendrite tree.…”