Coexistence of Epstein–Barr virus-associated gastric carcinoma with malignant lymphoma: report of two cases

Abstract

Epstein-Barr virus (EBV)-associated gastric carcinoma (EBV-GC) is not rare, accounting for 5 to 18% of all gastric carcinomas. Recently, we encountered two cases of EBV-GC of ordinary histopathological type coexistent with malignant lymphoma. One patient was a 71-year-old Japanese man who had two lesions, one in the cardia and the other in the antrum of the stomach. The former was EBV-GC without lymphoma, and antral one was EBV-GC with diffuse large B-cell lymphoma (DLBCL). The other patient was a 49-year-old Japanese man who had received chemotherapy for pelvic DLBCL 3 years earlier. He had EBV-GC with follicular lymphoma in the fundus of the stomach. In both cases, gastric carcinomas were positive for EBV-encoded small RNA by in situ hybridization, whereas the lymphoma cells, infiltrating nonneoplastic lymphocytes, and nonneoplastic epithelial cells were negative. The present cases suggest that focal immunosuppression by adjacent gastric lymphomas might be related to the alteration of the microenvironment and development of EBV-GC.

Collision of Lymphoepithelioma-like Carcinoma with Diffuse Large B-cell Lymphoma of the Stomach: A Case Report

“…Collision of EBV-associated GC with gastric non-Hodgkin lymphoma is extremely rare. According to the previous reports, five cases of EBV-associated GC with GL have been reported (2)(3)(4)(5)(6). This report described a rare case of a patient suffering from two different tumors.…”

Acute gastritis associated with Epstein-Barr virus infection in a child

“…There were no typical symptoms and signs of infectious mononucleosis in previous reports but their patients all had atypical lymphocytosis on peripheral blood. Related gastrointestinal cancers include gastric non-Hodgkin's lymphoma, gastric T-cell lymphoma, gastric adenocarcinoma, and esophageal cancer111213). Neurologic or blood disorders rarely occur1415).…”

Collision of EBV‐associated gastric carcinoma and primary gastric extranodal marginal zone lymphoma of mucosa‐associated lymphoid tissue in the remnant stomach

“…The reported cases of coexistence of EBV-associated GC and malignant lymphoma are limited. [6][7][8] Also, the collision of EBV-associated GC and gastric MALT lymphoma is extremely rare. Based on a PubMed literature search, only one case has been reported.…”