Coexistence of hyperthyroidism and thyroid cancer

Wahl, R. A.; Goretzki, P. E.; Meybier, H.; Nitschke, Jörg; Linder, M. M.; Röher, H.-D.

doi:10.1007/bf01657662

Cited by 64 publications

(21 citation statements)

References 12 publications

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“…The following is a detailed report of our surprising results: the incidence of carcinoma (44%) in hot nodules was considerably higher than reported in previous studies [2][3][4][5][6][7][8][9][10][11] on AFTL or hot nodules on radioiodine scans.…”

Section: Introductioncontrasting

confidence: 42%

Thyroid carcinoma m solitary hot thyroid lesions on Tc-99m sodium pertechnetate scans

et al. 1989

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Sixteen patients with nonsuppressible solitary hot thyroid lesions (SHTL) identified on T3 suppression images using Tc-99m sodium pertechnetate were studied over a period of 5 years. Of the 16 patients, 7 (44%) had papillary adenocarcinoma (PAC) and 9 (56%) had follicular adenoma (FA). Of the 7 patients with PAC, 3 were toxic and 4 nontoxic. Of the 9 patients with FA, 2 were toxic and 7 nontoxic. The Tl-201 chloride thyroid scans were useful in locating SHTL and revealing extranodular thyroid tissue. The echography was sensitive to visualization of the nodule structures. However, there were no significant differences between the clinical findings, radionuclide images, and echograms between for PAC and FA. All patients with PAC were treated by partial thyroidectomy and there were neither regional nor distant metastasis in any of them. In conclusion, our study provided the following extremely interesting result: SHTL in the present series have a higher incidence of malignancy than previously reported autonomously functioning thyroid lesions (AFTL). Histological examination is necessary for the diagnosis and management of SHTL and surgical treatment should be considered.

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Section: Introductioncontrasting

confidence: 42%

Thyroid carcinoma m solitary hot thyroid lesions on Tc-99m sodium pertechnetate scans

et al. 1989

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“…Previous reports suggest that diagnosis of TC in hyperthyroid patients was an accidental finding, often diagnosed intraoperatively or postoperatively [7,17,18]. In our series malignancy was diagnosed on FNAB cytology in 9 of 12 patients (75%) and 2 patients had suspicious cytology (16.7%) and 1 patient had nondiagnostic cytology (8.3%).…”

Section: Discussionmentioning

confidence: 42%

The incidence of hyperthyroidism in patients with thyroid cancer in an area of iodine deficiency

Gülçelik¹,

Gülçelik

Dinç³

et al. 2006

J. Surg. Oncol.

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“…The thyroid carcinomas of our two patients with decompensated autonomous adenoma were out¬ side the hot nodule and thus differed from those reported by Haid et al(12) and Kober et al(34), who found the thyroid carcinoma in cases of hy¬ perthyroidism to be largely localized in the auto¬ nomous adenoma (74% and 62%, respectively). In the patient material of Wahl et al(7) as well, 6 of 23 carcinomas in hyperthyroidism were detected inside decompensated autonomous adenomas. Meier & Hamburger(35) also report on a frequent occurrence of thyroid carcinomas in decompensa¬ ted autonomous adenomas with an incidence of 16.6% (3/18 patients).…”

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confidence: 94%

“…The carcinoma incidence was between 0.2 and 0.5% in the large investigation series of Beahrs et al (2;3029 patients with Graves' disease), Sokal (3; 13621 patients with hyperthy¬ roidism) and the prospective study of Dobyns et al (5; 10013 patients with Graves' disease) and was 2.5% in the patient material of Olen & Klinck (4; 2114 patients with hyperthyroidism), though an occult sclerosing papillary thyroid carcinoma was involved in half the cases. Later studies with com¬ paratively fewer patients reported a coincidence of the two diseases in 1.8 to 8.7% (6)(7)(8)(9)(10)(11)(12).…”

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confidence: 98%

Hyperthyroidism and thyroid carcinoma

Ahuja

Ernst²

1991

Acta Endocrinologica

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Twenty-two of 251 patients with differentiated thyroid carcinoma suffered from or had a history of hyperthyroidism. They were hyperthyroid with a diffuse goitre (N=4), a diffuse goitre with a cold nodule (N= 10), a multinodular goitre (N=6), and an autonomous adenoma (N=2). Among the 22 patients, more than one fourth had an occult thyroid carcinoma with a diameter of 1 cm or less, those with the papillary tumour types, less frequently had lymph node metastases than the total group of patients with papillary carcinomas (13.3 vs 35.6%). The clinical courses of the 22 patients resembled those of the other thyroid carcinoma patients whose age and initial findings were comparable. In 643 patients who underwent surgery for hyperthyroidism the incidence of thyroid carcinoma was 2.3%. The increase in coincidence of hyperthyroidism and thyroid carcinoma repeatedly reported in recent years is probably ascribable primarily to extensive and improved diagnostics and not to a direct connection between hyperthyroidism and development of thyroid carcinoma. On the other hand, our findings do confirm that, even in the presence of hyperthyroidism, all thyroid nodules require careful diagnostics for exclusion of malignancy.Opinions differ as to whether a connection exists between hyperthyroidism and thyroid carcinoma. In 1937, Means (1) still considered hyperthyroid¬ ism to be an "insurance against cancer of the thy¬ roid". This assumption was questioned in the early fifties (2,3), and, by the mid-sixties, a connection was even seen between hyperthyroidism and thy¬ roid carcinoma (4). The carcinoma incidence was between 0.2 and 0.5% in the large investigation series of Beahrs et al. (2;3029 patients with Graves' disease), Sokal (3; 13621 patients with hyperthy¬ roidism) and the prospective study of Dobyns et al.

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Coexistence of hyperthyroidism and thyroid cancer

Cited by 64 publications

References 12 publications

Thyroid carcinoma m solitary hot thyroid lesions on Tc-99m sodium pertechnetate scans

Thyroid carcinoma m solitary hot thyroid lesions on Tc-99m sodium pertechnetate scans

The incidence of hyperthyroidism in patients with thyroid cancer in an area of iodine deficiency

Hyperthyroidism and thyroid carcinoma

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