Coexistence of lipid phases in multilayer phospholipid films probed by Raman mapping

Shamaeva, Daria V.; Okotrub, Konstantin A.; Surovtsev, N. V.

doi:10.1039/d2an00490a

Cited by 4 publications

(1 citation statement)

References 33 publications

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“…Zwitterionic lipid bilayers (see Figure 1) contain both positive (choline, blue) and negative (phosphate, orange) functional groups, resulting in a relatively high dipole moment at physiological pH [25][26][27][28]. Phospholipids such as 1-palmitoyl-2-oleoyl-sn-glycero-3phosphocholine (POPC, 16:0/18:1 PC) and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC, 16:0/16:0 PC) spontaneously self assemble into bilayers in the presence of water (Figure 1), with their hydrophobic acyl tails forming the bilayer's hydrophobic core, while their headgroups interact with the aqueous phase [29]. Both lipids occur naturally, and are involved in different cellular processes on length scales ranging from the nanometer to the micrometer [30][31][32][33][34].…”

Section: Introductionmentioning

confidence: 99%

Real Space and Time Imaging of Collective Headgroup Dipole Motions in Zwitterionic Lipid Bilayers

et al. 2023

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Lipid bilayers are supramolecular structures responsible for a range of processes, such as transmembrane transport of ions and solutes, and sorting and replication of genetic materials, to name just a few. Some of these processes are transient and currently, cannot be visualized in real space and time. Here, we developed an approach using 1D, 2D, and 3D Van Hove correlation functions to image collective headgroup dipole motions in zwitterionic phospholipid bilayers. We show that both 2D and 3D spatiotemporal images of headgroup dipoles are consistent with commonly understood dynamic features of fluids. However, analysis of the 1D Van Hove function reveals lateral transient and re-emergent collective dynamics of the headgroup dipoles—occurring at picosecond time scales—that transmit and dissipate heat at longer times, due to relaxation processes. At the same time, the headgroup dipoles also generate membrane surface undulations due a collective tilting of the headgroup dipoles. A continuous intensity band of headgroup dipole spatiotemporal correlations—at nanometer length and nanosecond time scales—indicates that dipoles undergo stretching and squeezing elastic deformations. Importantly, the above mentioned intrinsic headgroup dipole motions can be externally stimulated at GHz-frequency scale, enhancing their flexoelectric and piezoelectric capabilities (i.e., increased conversion efficiency of mechanical energy into electric energy). In conclusion, we discuss how lipid membranes can provide molecular-level insights about biological learning and memory, and as platforms for the development of the next generation of neuromorphic computers.

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Section: Introductionmentioning

confidence: 99%

Real Space and Time Imaging of Collective Headgroup Dipole Motions in Zwitterionic Lipid Bilayers

et al. 2023

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In-plane and out-of-plane gigahertz sound velocities of saturated and unsaturated phospholipid bilayers from cryogenic to room temperatures

Dobrynina

Zykova

Surovtsev

2023

Chemistry and Physics of Lipids

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Characterization of conformational states of POPC and DPPCd62 in POPC/DPPCd62/cholesterol mixtures using Raman spectroscopy

Zaytseva

Surovtsev

2023

Chemistry and Physics of Lipids

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Coexistence of lipid phases in multilayer phospholipid films probed by Raman mapping

Abstract: Biomimetic phospholipid mixtures are actively used as models of biological membranes and materials for drug delivery in biomedical tasks. One of the essential properties of membranes formed from complex phospholipid...

Cited by 4 publications

References 33 publications

Real Space and Time Imaging of Collective Headgroup Dipole Motions in Zwitterionic Lipid Bilayers

Real Space and Time Imaging of Collective Headgroup Dipole Motions in Zwitterionic Lipid Bilayers

In-plane and out-of-plane gigahertz sound velocities of saturated and unsaturated phospholipid bilayers from cryogenic to room temperatures

Characterization of conformational states of POPC and DPPCd62 in POPC/DPPCd62/cholesterol mixtures using Raman spectroscopy

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