Coexistence of Oncogenic Human Papillomavirus Genotypes in Condylomata Acuminata among Children and Adolescents

Marsela, Enklajd; Fischbeck, Angelika J.; Hildebrand, Johannes Adrian; Aoki, Rui; French, Lars E.; Wollenberg, Andreas; Schmoeckel, Elisa; Reinholz, Markus

doi:10.2340/00015555-3407

Cited by 4 publications

(12 citation statements)

References 15 publications

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“…Possibly, this can be explained by differences in study populations, selection bias, different age ranges, limited information on confirmed sexual abuse, low numbers of cases examined, different types of samples (biopsies, swabs) and differences in sensitivity and covered type spectrum of the HPV-typing assays used. 16,17,[23][24][25][26][27] The present study is one of the few studies with a larger number of children (55 children) in a multicentre setting. For comprehensive HPV typing, AGW biopsies were analysed with multiple PCR protocols that cover more than 40 mucosal and cutaneous HPV types.…”

Section: Discussionmentioning

confidence: 94%

“…The results of studies on AGW in children are partly contradictory. Possibly, this can be explained by differences in study populations, selection bias, different age ranges, limited information on confirmed sexual abuse, low numbers of cases examined, different types of samples (biopsies, swabs) and differences in sensitivity and covered type spectrum of the HPV‐typing assays used 16,17,23–27 . The present study is one of the few studies with a larger number of children (55 children) in a multicentre setting.…”

Section: Discussionmentioning

confidence: 94%

“…23 In a recent single-centre study from Germany, HPV typing of 17 AGW of children and adolescents between 2 and 18 years of age was performed using a HPV-PCR assay that covers 32 mucosal alpha-HPV types. 24 In all seven children under the age of 12 years, HPV6 was identified, and three of these children additionally carried HPV16. 24 Information about suspected sexual abuse was not reported in that study.…”

Section: Discussionmentioning

confidence: 95%

“…In that study, five children (26%) additionally had high‐risk HPV types 16 or 33 23 . In a recent single‐centre study from Germany, HPV typing of 17 AGW of children and adolescents between 2 and 18 years of age was performed using a HPV‐PCR assay that covers 32 mucosal alpha‐HPV types 24 . In all seven children under the age of 12 years, HPV6 was identified, and three of these children additionally carried HPV16 24 .…”

Section: Discussionmentioning

confidence: 99%

“…This could be due to the use of PCR protocols that mainly amplify mucosal HPV-types. [23][24][25][29][30][31] For example, in a recent study from Brazil, 60% of 19 children with AGW carried mucosal HPV types. 23 In that study, five children (26%) additionally had high-risk HPV types 16 or 33.…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Human Papillomavirus‐type distribution in anogenital lesions of prepubertal children

Braun

Silling

Schloer

et al. 2021

Acad Dermatol Venereol

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Background In contrast to adults, only limited data are available on the human papillomavirus (HPV)-type spectrum in anogenital warts (AGW) of children.Objective This study aimed to evaluate the HPV-type spectrum in AGW of prepubertal children. Materials & methodsIn a retrospective German multicentre study, HPV genotyping was performed in AGW biopsies of 55 1-to 12-year-old children using HPV group-specific PCRs followed by hybridization with type-specific probes or sequence analysis.Results Human papillomavirus-DNA was found in 53 of the 55 AGW. In 58.5% (31/53) of the HPV-positive AGW, mucosal HPV types were detected. HPV6 (27/53, 50.9%) was the predominant type. 43.4% (23/53) of the lesions were induced by cutaneous HPV types (HPV2, HPV27, HPV57). Mucosal HPV types were significantly more common in children under 5 years of age than in children 5 years of age and older (22/25, 88.0% [95% CI: 70.0-95.8] vs. 9/28, 32.1% [95% CI: 17.9-50.7], P < 0.001). In contrast, cutaneous HPV types were significantly more prevalent in the 5-to 12-year age group (4/25,.1], P < 0.001). ConclusionAnogenital warts in 5-to 12-year-old children are frequently associated with cutaneous HPV types, possibly due to horizontal transmission. HPV typing, in addition to comprehensive clinical and psychosocial evaluation, can potentially help in the assessment of these cases.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Human Papillomavirus‐type distribution in anogenital lesions of prepubertal children

Braun

Silling

Schloer

et al. 2021

Acad Dermatol Venereol

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Relationship between α‐genus human papillomavirus and non‐genital seborrheic keratosis: Report of new cases and updated review

Nellessen

Aoki

Kammerbauer

et al. 2022

J of Cosmetic Dermatology

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Background: Seborrheic keratoses (SK) are the most common acquired benign tumor that affects middle-aged or older adults with great cosmetic concern. Clinical and histopathological similarities of SK and common warts have been addressed by investigating the possible presence of human papillomavirus (HPV) DNA in SK. Previous studies suggested the association between α-genus HPV and SK located on genital skin, whereas the causal relationship between α-HPV and non-genital SK remains controversial.Aim: This study aimed to clarify the pathogenic involvement of α-HPV in the development of non-genital SK. Methods:We analyzed α-HPV DNA prevalence and HPV genotypes using a PCRbased microarray on 51 skin samples presenting with histologically confirmed SK without any malignant changes. Correlation between the histological subtype of SK and their HPV DNA-positive reactivity was also evaluated. Results:Of 51 non-genital SK, two (3.9%) skin samples were positive for α-HPV DNA; high-risk HPV 31 and low-risk HPV 42 were found. Evaluation of HPV prevalence in different histological types of SK showed that both HPV-positive cases were acanthotic type; 14.3% of acanthotic SK lesions were positive, while all of the other types were negative for α-HPV. Conclusions:This study demonstrates that α-HPV positivity is very rare in common non-genital SK. The rare α-HPV-positive SK lesions histologically belonged to the acanthotic type, implying a potential impact of HPV infection on epidermal hyperproliferation. Although a possible association cannot be excluded, our findings suggest that α-HPV is not a major causative factor for non-genital SK.

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Lesiones anogenitales por Virus Papiloma Humano. Estudio de prevalencia en niños, niñas y adolescentes no vacunados

V.²,

O.³

et al. 2023

Andes pediatr

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La prevalencia de infección por virus Papiloma Humano (VPH) es desconocida en niños, niñas y adolescentes (NNA) chilenos. En 2014 se incorporó en Chile la vacuna VPH al Programa Nacional de Inmunizaciones en niñas y en varones el 2019. Objetivo: Determinar la prevalencia, genotipos y características de la infección por VPH en NNA con lesiones anogenitales no vacunados contra VPH. Pacientes y Método: Se estudiaron NNA con lesiones anogenitales que consultaron en el Hospital Calvo Mackenna entre 2013 y 2017. Se registró motivo de consulta, edad, sexo, antecedentes de familiar portador de lesiones por VPH, antecedente de vulneración sexual, y actividad sexual consentida. Se detectó VPH por PCR y tipificación mediante hibridación reversa en línea del gen L1. Las muestras se analizaron en la Sección de Virus Oncogénicos del Instituto de Salud Pública. Resultados: Se estudiaron 110 pacientes; 44.5% niños/as. Se detectó VPH en 34 (30,9% [IC95% 22,4- 40,4]); 22 (44,9%) niños/as y 12 (19,7%) adolescentes. Once (91,7%) adolescentes tenían antecedente de contacto sexual (p < 0,005); 4 (18,2%) niños/as develaron vulneración sexual. 25% de las lesiones genitales y 50% de las perianales eran VPH (+) (p 0,015). Los genotipos más frecuentes fueron 59, 58, 16, 18, 6 y 11. En niños/as se detectó sólo genotipos de bajo riesgo. En 91.7% de las adolescentes VPH (+) se detectaron genotipos de alto riesgo. Conclusión: La prevalencia de infección por VPH fue 30%. En adolescentes la infección estuvo relacionada a contacto sexual y a VPH de alto riesgo. En niños/as se asoció a genotipos de bajo riesgo. Las lesiones perianales se asociaron con mayor frecuencia que las genitales a infección por VPH. La inspección visual no permite precisar la etiología de las lesiones genitales, por lo que es necesario realizar test de PCR para virus papiloma humano.

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Coexistence of Oncogenic Human Papillomavirus Genotypes in Condylomata Acuminata among Children and Adolescents

Cited by 4 publications

References 15 publications

Human Papillomavirus‐type distribution in anogenital lesions of prepubertal children

Human Papillomavirus‐type distribution in anogenital lesions of prepubertal children

Relationship between α‐genus human papillomavirus and non‐genital seborrheic keratosis: Report of new cases and updated review

Lesiones anogenitales por Virus Papiloma Humano. Estudio de prevalencia en niños, niñas y adolescentes no vacunados

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