Coexistence of sclerosing polycystic adenosis and dysgenetic polycystic disease of parotid, Report of a case

Kahraman, Devrim; Yalavaç, Pýnar; Akar, Eylem; Ozen, Ozgur; Günhan, Ömer

doi:10.4103/ijpm.ijpm_502_18

Cited by 8 publications

(6 citation statements)

References 6 publications

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“…Thirteen studies have reported the presence of SPA in the parotid gland (Table 1) [3][4][5][6][7][8][9][10][11][12][13][14] ; all patients underwent total or superficial parotidectomy. The common clinical feature was a slowly growing and palpable but not painful SPA.…”

Section: Discussionmentioning

confidence: 99%

Sclerosing polycystic adenosis arising in the parotid gland with trismus: a case report and literature review

Yee

Han

Lee

et al. 2022

JKAOMS

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Sclerosing polycystic adenosis (SPA) is a rare, asymptomatic disease that occurs mainly in the salivary glands. We report the case of a 51-year-old man who presented with trismus and pain upon mouth opening. Magnetic resonance imaging revealed a 2-cm mass located in the anterior portion of the left parotid gland. SPA was diagnosed based on histopathological examination of the surgical specimen. In pathologic findings, there was a well-circumscribed multicystic nodule in the parenchyma. Dense fibrosis and chronic non-specific inflammatory cells were observed in the stroma. In 13 previous reports on SPA, the most preferred treatment was superficial or total parotidectomy. This report suggests that simple excision of SPA preserves facial nerve function and facial volume.

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Section: Discussionmentioning

confidence: 99%

Sclerosing polycystic adenosis arising in the parotid gland with trismus: a case report and literature review

Yee

Han

Lee

et al. 2022

JKAOMS

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“…SPA affects the parotid gland in approximately 70% of cases, with occasional cases affecting the submandibular glands or oral cavity [2,3,23,24]. Since 2006, only 38 cases of SPA affecting the parotid gland including the present case have been reported (Table S2) [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. SPA can occur in persons across a wide age range (7-84 years), with a median age of 46 years, and slight female predominance among reported cases (23 females, 15 males).…”

Section: Discussionmentioning

confidence: 99%

“…Unfortunately, published imaging findings of parotid SPA are limited given its rarity. Ultrasonographically, SPA tumors have been described as well-circumscribed, hypoechoic masses with microcystic areas [7,20]. On CT scan, the lesions have been described as well-circumscribed, hypodense masses exhibiting peripheral enhancement [15,17].…”

Section: Discussionmentioning

confidence: 99%

“…In the 2017 fourth update of the World Health Organization (WHO) classification of tumours of the salivary glands [1], SPA was categorized as a non-neoplastic epithelial lesion. Since 2006, only 38 cases of SPA arising in the parotid gland have been reported [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. Because of its rarity, neither the etiology nor the clinical features of SPA have been fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

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Sclerosing Polycystic Adenosis Arising in the Parotid Gland Without PI3K Pathway Mutations

Uemura

Bandoh

Goto

et al. 2021

Head and Neck Pathol

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A 15-year-old old Japanese male with a 2-month history of swelling of his left subauricular area was admitted to our department. A thumb-sized, hard mass with mild tenderness was palpated on the left parotid gland. Ultrasonography revealed a well-circumscribed, hypoechoic mass exhibiting heterogeneity in the left parotid gland measuring 1.7 × 1.5 × 1.3 cm. Computed tomography scan revealed a well-circumscribed, solid mass exhibiting slight peripheral enhancement in the left parotid gland. Magnetic resonance imaging revealed a hypointense mass in the left parotid gland on both T1-and T2-weighted images. Clinicoradiologic findings suggested a benign or low-grade malignant parotid tumor. The patient underwent left superficial parotidectomy with adequate safety margins. The facial nerve was identified and preserved. Neither facial paralysis nor tumor recurrence was observed as of 1 year postoperatively. Histologically, the nodule consisted of a vaguely nodular arrangement of variably sized ducts and acini in a hyalinized fibrous background with focal myxoid changes. The ductal/ acinar component exhibited a bilayered arrangement of cuboidal luminal and flattened abluminal cells exhibiting a variety of epithelial proliferative patterns, including micropapillary and cribriform. Areas of oncocyte-like changes with intracellular coarse eosinophilic granules, apocrine-like feature, foamy/vacuolated changes, and clear cells were noted in the proliferating epithelium. Immunohistologically, the luminal cells were positive for gross cystic disease fluid protein-15. The Ki-67 labeling index was 2-3%. The histologic features and immunohistologic profile were consistent with sclerosing polycystic adenosis. Targeted next-generation sequencing of 160 cancer-related genes using the surgical specimen revealed no mutations, including known significant mutations in PTEN, PIK3CA, or PIK3R1.

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“…SPA is characterised by morphological similarity to fibrocystic changes, sclerosing adenosis and intraductal epithelial proliferation of the breast. It occurs over a broad age spectrum and is mostly single‐site 26–28 . The lesions are circumscribed lobules, featuring densely sclerotic areas with prominent cystic, metaplastic, and hyperplastic changes in the ductal and acinar elements.…”

Section: Oncocyte‐predominant Non‐mucinous Cystmentioning

confidence: 99%

Cystic lesions in the salivary gland. Pitfalls to be avoided on cytology

et al. 2023

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Cystic lesions of the salivary glands are very uncommon entities. However, on occasion, some neoplasms of the salivary glands show a cystic component, which may be predominant or only partially cystic. Basal cell adenoma, canalicular adenoma, oncocytoma, sebaceous adenoma, intraductal papilloma, epithelial‐myoepithelial carcinoma, intraductal carcinoma, and secretory carcinoma are such cystic entities. Cystic degeneration and necrosis, which can develop within solid tumours, represent another possibility. The ability to recognise this type of lesion is a challenge in diagnostic cytology because hypocellular fluid is frequently recovered. Furthermore, evaluating all of the differential diagnoses for cystic lesions of the salivary glands is helpful in obtaining the correct diagnosis. Herein, we evaluate the various types of cystic lesions within the salivary glands.

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Coexistence of sclerosing polycystic adenosis and dysgenetic polycystic disease of parotid, Report of a case

Cited by 8 publications

References 6 publications

Sclerosing polycystic adenosis arising in the parotid gland with trismus: a case report and literature review

Sclerosing polycystic adenosis arising in the parotid gland with trismus: a case report and literature review

Sclerosing Polycystic Adenosis Arising in the Parotid Gland Without PI3K Pathway Mutations

Cystic lesions in the salivary gland. Pitfalls to be avoided on cytology

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