Coexistent Idiopathic Thrombocytopenic Purpura and Hyperthyroidism

Marshall, James S.; Weisberger, Austin S.; Levy, Richard P.; Breckenridge, Robert T.

doi:10.7326/0003-4819-67-2-411

Cited by 51 publications

(23 citation statements)

References 7 publications

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“…It was reported that GDis complicated by immune thrombocytopenic purpura with a statistically higher frequency compared with other diseases (7). It is considered that development of both GDand immune thrombocytopenic purpura may be involved in a similar autoimmunemechanism (7,9). It has also been reported that improvement of thyroid function by administration of antithyroid drug was followed by recovery of platelet counts (8, ll).…”

Section: Discussionmentioning

confidence: 99%

“…Graves' disease (GD) is caused by autoimmune nature, and is sometimesaccompaniedwith other autoimmunediseases, such as typel diabetes mellitus (1), myasthenia gravis (2-4), Sjogren's syndrome (5,6), and immune thrombocytopenic purpura (7)(8)(9)(10)(11)(12). Whereas a few reports describe the association of GD with polymyositis (PM) (2,3,(13)(14)(15), dermatomyositis (DM) (16,17), and scleroderma (13,(18)(19)(20)(21) in the English-language literature, there is only one case report describing a patient with GDcomplicated with PMand scleroderma (13).…”

Section: Introductionmentioning

confidence: 99%

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Anti-Ku Antibody-Positive Scleroderma-Dermatomyositis Overlap Syndrome Developing Graves' Disease and Immune Thrombocytopenic Purpura.

et al. 2002

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Graves' disease (GD) has been reported to be frequently complicated with other autoimmune diseases. However, it is rarely complicated with scleroderma-polymyositis overlap syndrome. Recently, we encountered a 35-year-old womanwhodeveloped GDand immunethrombocytopenic purpura during follow-up observation of scleroderma-dermatomyositis overlap syndrome. Platelet counts recovered after high-dose y-globulin therapy and bolus methylprednisolone therapy. The present case is the first report of a combination of scleroderma, dermatomyositis, GD, and immunethrombocytopenic purpura. The patient was antiKu antibody-positive and had relatively low natural killer T cell counts, both of which might contribute to the complication of multiple autoimmune diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anti-Ku Antibody-Positive Scleroderma-Dermatomyositis Overlap Syndrome Developing Graves' Disease and Immune Thrombocytopenic Purpura.

et al. 2002

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“…Cordiano et al found that w80% of patients with hyperthyroidism and thrombocytopenia had platelet autoantibodies (48). Conversely, Marshall et al reported that 6 of 42 patients (14% of total) with diagnosed AITP developed hyperthyroidism during the follow-up of the study (43).…”

Section: Hyperthyroidismmentioning

confidence: 99%

Hemostatic abnormalities in endocrine and metabolic disorders

Franchini¹,

Lippi²,

Manzato³

et al. 2010

European Journal of Endocrinology

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The hemostatic balance is a complex system where the delicate equilibrium is regulated by several factors, including hormones. This review summarizes current knowledge of the effects of most frequent endocrine and metabolic diseases (such as hypothyroidism, hyperthyroidism, Cushing's syndrome, GH-related pituitary dysfunctions, pituitary prolactin-producing adenomas, polycystic ovary syndrome, primary hyperparathyroidism, and metabolic syndrome) on coagulation and fibrinolysis. Overt hypothyroidism appears to be associated with a bleeding tendency, whereas all other endocrine diseases appear to be associated with a thrombotic tendency. Globally, the disorders of coagulation and fibrinolysis usually range from mild to moderate, and, rarely, to severe laboratory abnormalities (for example, bleeding diathesis in overt hypothyroidism mainly due to an acquired von Willebrand's disease type 1). Further larger and high-quality studies are needed to provide more definitive information on the effects of endocrine disorders on coagulation and fibrinolysis.

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“…It has been estimated that at least 14% of patients with idiopathic thrombocytopenic purpura have underlying Graves disease [7], and that 43% of patients with hyperthyroidism have platelet counts below 150,000/mm3 [8]. Furthermore, half the patients with autoimmune hyperthyroidism and thrombocytopenia have been shown to have elevated platelet IgG levels, and no association was noted with the thyroid status at the time the platelet studies were performed [9].…”

Section: Discuss I 0 Nmentioning

confidence: 99%