Coexistent Papillary Carcinoma of Thyroid and Hashimoto’s Thyroiditis – Diagnosis on Fine Needle Aspiration Cytology

Makhdoomi, Rumana; Mustafa, Farhat; Malik, R; Bhat, Salma; Alam, Khurshid; Bashir, Humaira; Samoon, Nuzhat; Rasool, Mohsin; Baba, Khalil

doi:10.5812/ijem.7453

Cited by 4 publications

(1 citation statement)

References 11 publications

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“…If sample sections are not taken properly and careful grossing is not done then foci of microcarcinoma may be missed in a patient who has Hashimoto's thyroiditis. 14…”

Section: Described Expression Of the Ret/ptc1 And Ret/ptc3 Oncogenes Inmentioning

confidence: 99%

Coexistence of Hashimoto's thyroiditis with papillary carcinoma thyroid: A rare case report with review of literature

S¹,

M²,

N³

et al. 2014

Inte. Jour. of Medi. Res. & Health Sci.

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Hashimoto's thyroiditis is an inflammatory disease of the thyroid gland. It has an autoimmune etiology. A higher incidence of papillary thyroid carcinoma with Hashimoto's thyroiditis was reported in several studies. 51 year old female patient presented with a swelling in front of the neck region since 5 years. Clinical examination revealed a swelling about 4x4x3 cm, smooth, tender, non-pulsatile and moved with deglutition. Ultrasonography revealed multinodular goiter without evidence of lymphadenpathy. Thyroid profile was done. Patient was euthyroid. FNAC reported as benign lesion. Hemithyroidectomy was done. Grossly thyroidectomy specimen i.e. hemithyroid 6x3x3 cm was received which was externally capsulated and nodular. Cut section showed a greyish white area and cystic areas each of size 1x1 cm filled with haemorrhagic and mucoid material respectively. Microscopy showed thyroid follicles with lymphoid infiltrate in the stroma forming follicles with germinal centres. Hurthle cell change was also noted. Section from both cystic areas showed plenty of complex branching papillae with fibrovascular core lined by cuboidal cells showing ground glass nuclei. The case was diagnosed as papillary carcinoma in Hashimoto's thyroiditis. The frequency of the association of Hashimoto's thyroiditis and differentiated thyroid carcinoma is approximately 30%. However, the presence of Hashimoto's thyroiditis has no effect on the diagnostic evaluation and management of papillary carcinoma of thyroid. Yet, one has to keep an eye for the features of papillary carcinoma in case of Hashimoto's thyroiditis. So a thorough grossing of thyroid specimen is recommended especially in patients who have Hashimoto's thyroiditis.

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“…If sample sections are not taken properly and careful grossing is not done then foci of microcarcinoma may be missed in a patient who has Hashimoto's thyroiditis. 14…”

Section: Described Expression Of the Ret/ptc1 And Ret/ptc3 Oncogenes Inmentioning

confidence: 99%

Coexistence of Hashimoto's thyroiditis with papillary carcinoma thyroid: A rare case report with review of literature

S¹,

M²,

N³

et al. 2014

Inte. Jour. of Medi. Res. & Health Sci.

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Papillary Thyroid Cancer and Hashimoto’s Thyroiditis: An Association Less Understood

Anand

Singh

Kushwaha

et al. 2014

Indian J Surg Oncol

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Hashimoto's thyroiditis (HT), part of the spectrum of autoimmune thyroid diseases is a major cause of thyroid hypofunction worldwide. Papillary thyroid carcinoma (PTC), the most prevalent of all thyroid carcinomas has been associated with HT. Literature on this association are based on preoperative FNA or post thyroidectomy histopathology reports, which are subject to potential biases. Molecular, hormonal and histopathalogical basis of this association has been hypothesized, however a definite causal association has not been proved till date. This review aims to study the basis of this association and clinical features and management of HT concurrent with PTC. There are no distinctive clinical or radiological features that categorically differentiates HT concurrent with PTC from PTC or which can pick up a nodule harboring PTC in setting of HT. Smaller nodule size and radiological features like hypoechogenecity; hyper vascularity and calcification in a clinical setting of hypothyroidism have a higher odds ratio for malignancy and merit further investigations. PTC associated with HT has been seen to be less aggressive with earlier presentation with lesser chances of extra thyroidal extension and lymph nodal metastasis. The management and follow up of PTC in HT is no different from that of PTC alone. The prognosis of PTC concurrent with HT is better compared to age and stage matched PTC in terms of lower recurrence and disease free and overall survival.

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Variety of Combinations of Hashimoto’s Thyroiditis With Other Background Pathology of Thyroid Parenchema in Different Forms of Thyroid Cancer

Karachentsev

Дубовик

Gopkalova

et al. 2020

VPBM

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Coexistent Papillary Carcinoma of Thyroid and Hashimoto’s Thyroiditis – Diagnosis on Fine Needle Aspiration Cytology

Cited by 4 publications

References 11 publications

Coexistence of Hashimoto's thyroiditis with papillary carcinoma thyroid: A rare case report with review of literature

Coexistence of Hashimoto's thyroiditis with papillary carcinoma thyroid: A rare case report with review of literature

Papillary Thyroid Cancer and Hashimoto’s Thyroiditis: An Association Less Understood

Variety of Combinations of Hashimoto’s Thyroiditis With Other Background Pathology of Thyroid Parenchema in Different Forms of Thyroid Cancer

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