Coexisting genital malignancies with tuberculosis: A case series with review of literature

Abstract

Objective:To study a case series of genital malignancies coexisting with genital tuberculosis.Materials and Methods:A series of three cases with known genital malignancies were found to have coexisting genital tuberculosis on subsequent workup.Results:First case was a 45 years old lady who underwent staging laparotomy for ovarian cancer. On histopathology examination, there was coexisting tuberculosis with papillary serous carcinoma. Second case was 53 years old postmenopausal lady who underwent extrafascial hysterectomy along with pelvic lymph node dissection. Histopathology showed tubercular changes along with endometrial malignancy. Third patient was a 50 years old postmenopausal lady with stage IIA carcinoma of cervix. She underwent radical hysterectomy and histopathology revealed tubercular changes in pelvic lymph nodes. All patients were given antitubercular therapy for 9 months in postoperative period along with adjuvant therapy.Conclusion:Although diagnosed as an incidental finding in the case series, genital tuberculosis may present in patients with malignancies as a result of immunosupression.

Recent Advances in Diagnosis and Management of Female Genital Tuberculosis

“…We have described Sharma’s parachute sign in abdomino-pelvic TB with ascending colon being adherent to anterior abdominal wall making putting second port of laparoscope risky and hazardous on right side [ 37 ]. Abdomino-pelvic TB may sometimes be coexistent with malignancies or endometriosis [ 38 , 39 ].…”

Co-existent abdominoperitoneal tuberculosis with endometrial cancer: A diagnostic and surgical challenge

“…These presenting clinical features may mimic advanced gynaecological cancers, notably of ovarian origin, making diagnosis of either condition difficult. To date, many authors have reported cases of ovarian cancer with co-existent tuberculosis, describing similar diagnostic and therapeutic conundrums ( Sharma et al, 2010 , Koc et al, 2006 , Gupta et al, 2016 ). However, to the best of our knowledge, there have only been two case reports documenting coexistent endometrial cancer with APTB ( Saygili et al, 2002 , Castelo-Branco et al, 1995 ).…”

Immune disturbances in female genital tuberculosis and latent genital tuberculosis

“…We have observed new laparoscopic signs in FGTB and abdomino‐pelvic TB like perihepatic adhesions (Fitz Hugh Curtis Syndrome) with Sharma's hanging gall bladder sign, Sharma's ascending colonic adhesions, Sharma's parachute sign (adhesions of ascending colon to anterior abdominal wall making putting a second port of laparoscope on right side hazardous), Sharma's sigmoid colonic adhesive band and Sharma's compartmentalization sign 29–34 . FGTB and abdomino‐pelvic TB may concomitantly be present with endometriosis or malignancies 35–36 . Tuberculosis of vulva may present as vulval tumor or hypertrophic vulvitis and genital fistula 37,38 .…”