Coffea arabica: A Plant with Rich Content in Caffeine

Patay, Éva Brigitta; Fritea, Luminița; Antonescu, Andreea; AngelaAntonescu,; Dobjanschi, Luciana

doi:10.5772/intechopen.68149

Cited by 7 publications

(3 citation statements)

References 58 publications

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“…Indeed, they were shown to have deleterious effects on coffee microbial pathogens: a study showed that coffee plants supplied with silicon-a resistance inducer-had higher levels of chlorogenic acids and were therefore more resistant to Hemilea vastatrix, the causal agent of rust (Rodrigues et al, 2011). Caffeine content is one of the most important traits for coffee selection, either to bean processing for beverage consumption or for the pharmaceutical industry (Sawynok, 1995;Leroy et al, 2006;Patay et al, 2017;Carvalho et al, 2019). Having a resourceful method for caffeine detection and quantification, along with other desirable traits, would aid coffee breeders and studies on cultivar development.…”

Section: A B Cmentioning

confidence: 99%

A metabolomic platform to identify and quantify polyphenols in coffee and related species using liquid chromatography mass spectrometry

Castro-Moretti

Cocuron²,

Castillo-Gonzalez³

et al. 2023

Front. Plant Sci.

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IntroductionProducts of plant secondary metabolism, such as phenolic compounds, flavonoids, alkaloids, and hormones, play an important role in plant growth, development, stress resistance. The plant family Rubiaceae is extremely diverse and abundant in Central America and contains several economically important genera, e.g. Coffea and other medicinal plants. These are known for the production of bioactive polyphenols (e.g. caffeine and quinine), which have had major impacts on human society. The overall goal of this study was to develop a high-throughput workflow to identify and quantify plant polyphenols.MethodsFirst, a method was optimized to extract over 40 families of phytochemicals. Then, a high-throughput metabolomic platform has been developed to identify and quantify 184 polyphenols in 15 min.ResultsThe current metabolomics study of secondary metabolites was conducted on leaves from one commercial coffee variety and two wild species that also belong to the Rubiaceae family. Global profiling was performed using liquid chromatography high-resolution time-of-flight mass spectrometry. Features whose abundance was significantly different between coffee species were discriminated using statistical analysis and annotated using spectral databases. The identified features were validated by commercially available standards using our newly developed liquid chromatography tandem mass spectrometry method.DiscussionCaffeine, trigonelline and theobromine were highly abundant in coffee leaves, as expected. Interestingly, wild Rubiaceae leaves had a higher diversity of phytochemicals in comparison to commercial coffee: defense-related molecules, such as phenylpropanoids (e.g., cinnamic acid), the terpenoid gibberellic acid, and the monolignol sinapaldehyde were found more abundantly in wild Rubiaceae leaves.

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Section: A B Cmentioning

confidence: 99%

A metabolomic platform to identify and quantify polyphenols in coffee and related species using liquid chromatography mass spectrometry

Castro-Moretti

Cocuron²,

Castillo-Gonzalez³

et al. 2023

Front. Plant Sci.

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“…However, the coffee plant was known as the main source of caffeine than other plants. Caffeine was found in the leaves, especially at upper leaves and seeds, but not in cotyledons (Patay et al 2017). Biosynthesis of caffeine in leaves of Coffea arabica was from adenine that was converted into 7-methylxanthosine, then into 7methylxanthine and theobromine and finally into caffeine (Ashihara et al 1996).…”

Section: Introductionmentioning

confidence: 97%

Caffeine degradation by food microorganisms

et al. 2023

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Abstract. Purwoko T, Suranto, Setyaningsih R, Marliyana SD. 2023. Caffeine degradation by food microorganisms. Biodiversitas 24: 3495-3502. Commercial coffee beans are dominated by robusta and arabica coffee beans. Caffeine is one of the important components in coffee beans. Caffeine has antimicrobial effect. Caffeine content in robusta beans was higher than in arabica beans. Caffeine content in coffee beans was affected by the coffee species, the coffee cultivation's altitude and the postharvest processing method. Microbial fermentation activity could reduce the caffeine content of coffee beans. Lactobacillus casei, Leuconostoc mesenteroides, Rhizopus oryzae and Saccharomyces cerevisiae, were able to reduce caffeine content of robusta beans. This study aimed to determine the degradation pathway of caffeine by food microorganisms, namely L. casei, L. mesenteroides, R. oryzae and S. cerevisiae. Caffeine content in NB-caffeine and PDB-caffeine media were reduced by L. casei, L. mesenteroides, R. oryzae and S. cerevisiae. Caffeine was transformed into dimethylxanthine and then into methylxanthine by L. casei, L. mesenteroides, R. oryzae and S. cerevisiae. They transformed more than 89% caffeine into paraxanthine, however, small amount of paraxanthine was transformed into methylxanthine. L. casei and L. mesenteroides transformed paraxanthine into 1-methylxanthine. However, R. oryzae and S. cerevisiae transformed into 7-methylxanthine. There were two patterns of degradation of caffeine into methylxanthine i.e., caffeine-paraxanthine-1-methylxanthine and caffeine-paraxanthine-7-methylxanthine. The first was shown by L. casei and L. mesenteroides, and the last by R. oryzae and S. cerevisiae.

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“…Coffea arabica Linn (Bunna in the Amharic language), a plant from the genus Coffea and Rubiaceae family, is an evergreen shrub that grows in subtropical and tropical regions [ 7 , 8 ]. Many in vivo and in vitro experimental studies on C. arabica Linn extracts showed sympathomimetic [ 9 ], anti-inflammatory and antioxidant [ 10 ], antibacterial and antiviral [ 11 ], smooth muscle relaxant [ 12 ], suppression of metalloproteinase expression, and improved skin wound healing activities [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Antidiarrheal Effect of 80% Methanol Extract and Fractions of the Roasted Seed of Coffea arabica Linn (Rubiaceae) in Swiss Albino Mice

Alemu

Wubneh

Adugna

2022

Evidence-Based Complementary and Alternative Medicine

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Background. Globally in 2019, diarrhea was the second leading cause of mortality in children, accounting for more than half a million under-five deaths yearly. Several societies use Coffea arabica Linn for the treatment of diarrhea. However, its use is not scientifically validated. Objective. The study was conducted to evaluate antidiarrheal activity of 80% methanol extract and solvent fractions of roasted seed of Coffea arabica Linn in mice. Methods. Coffea arabica Linn seed was roasted, milled, extracted, and fractionated using hexane, ethyl acetate, and distilled water. Castor oil-induced diarrhea, enteropooling, and motility tests were conducted. Effects on onset, number of feces, weight of feces, fluid content, volume and weight of intestinal content, and motility were evaluated by administering 100 mg/kg, 200 mg/kg, and 400 mg/kg of each extract. Negative controls received 10 ml/kg of the vehicle, and positive controls received either loperamide (3 mg/kg) or atropine (1 mg/kg). Data were analyzed using one-way ANOVA followed by Tukey’s post hoc test. Results. Ethyl acetate fraction at all tested doses significantly prolonged ( p < 0.05 ) onset of diarrhea. The number and weight of feces were also reduced significantly by crude extract and ethyl acetate fraction. Reduction in fluid content was observed at 200 mg/kg and 400 mg/kg of the crude extract ( p < 0.01 ) and aqueous fraction ( p < 0.001 ) as well as all tested doses of ethyl acetate fraction ( p < 0.001 ). Similarly, the crude extract, ethyl acetate fraction, and aqueous fraction showed a significant reduction in the volume and weight of intestinal content. At 400 mg/kg, the crude extract, hexane fraction, aqueous fraction, and all doses of ethyl acetate fraction showed significant antimotility activity. Conclusion. The results of this study revealed that the roasted seed of Coffea arabica Linn has antidiarrheal activity.

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Coffea arabica: A Plant with Rich Content in Caffeine

Cited by 7 publications

References 58 publications

A metabolomic platform to identify and quantify polyphenols in coffee and related species using liquid chromatography mass spectrometry

A metabolomic platform to identify and quantify polyphenols in coffee and related species using liquid chromatography mass spectrometry

Caffeine degradation by food microorganisms

Antidiarrheal Effect of 80% Methanol Extract and Fractions of the Roasted Seed of Coffea arabica Linn (Rubiaceae) in Swiss Albino Mice

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