Coffee and its chemopreventive components Kahweol and Cafestol increase the activity of O6-methylguanine-DNA methyltransferase in rat liver—comparison with phase II xenobiotic metabolism

Huber, Wolfgang; Scharf, Gerlinde; Nagel, Georg; Prustomersky, Sonja; Schulte‐Hermann, Rolf; Kaina, Bernd

doi:10.1016/s0027-5107(02)00264-6

Cited by 77 publications

(47 citation statements)

References 60 publications

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“…Another potential mechanism that might be implicated involves the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT). The coffee components kahweol and cafestol have been reported to increase MGMT activity in rat liver (18). Similarly, the tea component polyphenol (2)-epigallocatechin-3-gallate reactivates methylation-silenced genes, including MGMT, in cancer cell lines (19).…”

Section: Discussionmentioning

confidence: 99%

Coffee and tea intake and risk of brain tumors in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study

Michaud¹,

Gallo²,

Schlehofer³

et al. 2010

The American Journal of Clinical Nutrition

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Background: In a recent US cohort study, total coffee and tea consumption was inversely associated with risk of glioma, and experimental studies showed that caffeine can slow the invasive growth of glioblastoma. Objective: The objective was to examine the relation between coffee and tea intake and the risk of glioma and meningioma in a large European cohort study, the European Prospective Investigation into Cancer and Nutrition (EPIC). Design: Data on coffee and tea intake were collected from men and women recruited into the EPIC cohort study. Over an average of 8.5 y of follow-up, 343 cases of glioma and 245 cases of meningioma were newly diagnosed in 9 countries. We used Cox proportional hazards models to examine the relation between coffee and tea and brain tumors. Results: We observed no associations between coffee, tea, or combined coffee and tea consumption and risk of either type of brain tumor when using quantiles based on country-specific distributions of intake. However, a significant inverse association was observed for glioma risk among those consuming 100 mL coffee and tea per day compared with those consuming ,100 mL/d (hazard ratio: 0.66; 95% CI: 0.44, 0.97; P = 0.03). The association was slightly stronger in men (hazard ratio: 0.59; 95% CI: 0.34, 1.01) than in women (hazard ratio: 0.74; 95% CI: 0.42, 1.31), although neither was statistically significant. Conclusions: In this large cohort study, we observed an inverse association between total coffee and tea consumption and risk of glioma that was consistent with the findings of a recent study. These findings, if further replicated in other studies, may provide new avenues of research on gliomas.

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Section: Discussionmentioning

confidence: 99%

Coffee and tea intake and risk of brain tumors in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study

Michaud¹,

Gallo²,

Schlehofer³

et al. 2010

The American Journal of Clinical Nutrition

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“…Turkish coffee was prepared every 2 days freshly according to described procedure [13]. Briefly, an equivalent of 5 g coffee/10 g sucrose/60 ml tap water was heated to boiling and subsequently cooled.…”

Section: Study Design and Groupsmentioning

confidence: 99%

“…The coffee was separated form the sediment, homogenized by stirring, its concentration initially adjusted with tap water according to treatment schedule, filled into the drinking bottles. The percentage of the beverage in the drinking liquid was gradually increased by 25% upon every fresh preparation, thus reaching 100% on treatment day 7 as described procedure by Huber et al [13]. From the previously published K/C content of Turkish coffee of 180 mg/l [6] and the actual liquid consumption in our present study the average daily intake of K/C was estimated to have been 6 mg/day per rat (range: 3-9) during the treatment period (reach 9 mg/day per rat with pure coffee).…”

Section: Study Design and Groupsmentioning

confidence: 99%

Effect of Unfiltered Coffee on Carbon Tetrachloride-Induced Liver Injury in Rats

et al. 2008

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To assess the role of unfiltered coffee upon carbon tetrachloride (CCl 4 ) induced hepatotoxicity in rats. All rats were randomly divided into control group, CCl 4 -treated, unfiltered coffee-treated and CCl 4 /unfiltered coffee-treated. Hepatic damage was induced by repeated intraperitoneal injections of CCl 4 every other day. Unfiltered coffee was given as drinking fluid for 8 days starting the day before CCl 4 administration. Liver enzymes, plasma and liver tissue malondialdehyde were analyzed. Histopathological evaluation of liver sections was performed. Serum aminotransferase level significantly increased in CCl 4 /unfiltered coffee-treated group compared to CCl 4 -treated group, as well as, lipid peroxidation products in the plasma and liver tissue. In addition, histopathological findings including inflammation and necrosis were significantly confirmed these findings. Unfiltered coffee potentiates acute liver injury in rats with CCl 4 -induced hepatotoxicity.

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“…Abreu et al, [55] found that the consumption of coffee decreased the lipid peroxidation of the membranes; increased the concentration of glutathione, a potent endogenous antioxidant; and increased the activity of two antioxidant enzymes, glutathione reductase and superoxide dismutase. Undoubtedly, these beneficial effects of coffee on antioxidant properties are partly due to caffeine, kahweol and cafestol [56][57][58]. In addition to the effect of coffee, cardamom also have a potential antioxidants such as 1, 8-ceineoil and alphaterpineol, protocatechualdehyde and protocatechuic acid which have health benefits by inhibiting lipid peroxidation and activation of antioxidant enzymes [24,25].…”

Section: Essential Oil %mentioning

confidence: 99%

Using of Coffee and Cardamom Mixture to Ameliorate Oxidative Stress Induced in γ-irradiated Rats

Hamzaa¹,

Osman²

2012

Biochem Anal Biochem

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Human exposure to ionizing radiation induced overproduction of free radicals leading to oxidative stress. This study aims to evaluate the possibility of using of coffee and cardamom mixture, as natural antioxidant compounds, to ameliorate the damage effect of oxidative stress. Phenolic contents in coffee and essential oils in cardamom were identified by using HPLC chromatography and GC/MS analysis. Four groups of adult male rats were used; the control group (A), the second group (B) received orally mixture extract of coffee and cardamom (60 mg/100g body weight) for 8 weeks, the third group (C) γ-irradiated (6 GY) and the fourth group (D) received orally mixture extract for 8 weeks and exposed to γ-irradiation at the 4th week. The results revealed that the administration of mixture extract of coffee and cardamom were significantly reduced the damage effect induced by γ-irradiation exposure. Accordingly, it could be concluded that, via the adjustment of the antioxidant status, decreasing the releasing of lipid peroxides and the subsequent amending of different biochemical parameters and some hormones, mixture of coffee and cardamom could ameliorate the hazardous effects of oxidative stress induced by irradiation exposure.

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Coffee and its chemopreventive components Kahweol and Cafestol increase the activity of O6-methylguanine-DNA methyltransferase in rat liver—comparison with phase II xenobiotic metabolism

Cited by 77 publications

References 60 publications

Coffee and tea intake and risk of brain tumors in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study

Coffee and tea intake and risk of brain tumors in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study

Effect of Unfiltered Coffee on Carbon Tetrachloride-Induced Liver Injury in Rats

Using of Coffee and Cardamom Mixture to Ameliorate Oxidative Stress Induced in γ-irradiated Rats

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