Coffee and tea consumption and the risk of glioma: a systematic review and dose–response meta-analysis

Pranata, Raymond; Feraldho, Andrea; Lim, Michael Anthonius; Henrina, Joshua; Vania, Rachel; Golden, Nyoman; July, Julius

doi:10.1017/s0007114521000830

Cited by 18 publications

(8 citation statements)

References 38 publications

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“…Every extra cup of tea daily could reduce the risk of glioma by 7%, while the result of coffee was not significant (17,18). Pranata et al obtained the same conclusion through a meta-analysis (19). However, in three large prospective cohort studies in the UK and the USA, Kuan et al analyzed the effects of 15 food groups on glioma at different follow-up times, no significant effect was found (20).…”

Section: Introductionmentioning

confidence: 91%

Dietary Factors and Risk of Glioma in Adults: A Systematic Review and Dose-Response Meta-Analysis of Observational Studies

Zhang

Jiang

et al. 2022

Front. Nutr.

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BackgroundGliomas are the most common primary intracranial tumors in adults. Inappropriate dietary habits are thought to be a risk factor for most human cancer, and glioma is no exception. However, the effect of dietary factors on glioma is not clear.ObjectiveThis review aims to quantitatively evaluate the association between various dietary intakes and glioma using a meta-analysis.MethodsWe searched articles on PubMed, the Cochrane Library, the Web of Science, and EMBASE from their inception until October 11, 2021. According to heterogeneity, the fixed-effects or random-effects model was selected to obtain the relative risk (RR) of merger. Based on the methods described by Greenland and Longnecker, we explored the dose-response relationship between dietary intakes and the risk of glioma. Subgroup analysis, sensitivity analysis, and publication bias were also used.ResultsThis study reviewed 33 articles, including 3,606,015 controls and 8,831 patients with glioma. This study included 12 food groups. Compared with the lowest intakes, the highest intakes of tea (RR = 0.82, 95%CI:0.71–0.93), total vegetables (RR = 0.84, 95%CI: 0.70–1.00), green vegetables (RR = 0.80, 95%CI: 0.66–0.98), and orange vegetables (RR = 0.79, 95%CI: 0.66–0.96) significantly reduced the risk of glioma, while the highest intakes of grains (RR = 1.39, 95%CI: 1.16–1.66), processed meats (RR = 1.19, 95%CI: 1.00–1.42), and processed fish (RR = 1.37, 95%CI: 1.03–1.84) significantly increased the risk of glioma. The results of subgroup and sensitivity analyses remained unchanged. In the dose-response relationship, only tea was statistically significant. Taking an extra cup of tea every day reduced the risk of glioma by 4%.ConclusionsOur analysis suggests that the intakes of tea, total vegetables, green vegetables, and orange vegetables may reduce the risk of glioma, while the intakes of grains, processed meats, and processed fish may increase the risk of glioma. Therefore, the effect of dietary factors on glioma should not be ignored.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/, CRD42022296658.

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Section: Introductionmentioning

confidence: 91%

Dietary Factors and Risk of Glioma in Adults: A Systematic Review and Dose-Response Meta-Analysis of Observational Studies

Zhang

Jiang

et al. 2022

Front. Nutr.

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“…A meta-analysis of 12 studies comprising 1,960,731 participants along with 2987 glioma cases showed that every single cup of tea or coffee per day reduces the risk of glioma to 3%. Presence of antioxidants especially polyphenols in tea or coffee may contribute to the overall chemopreventive effect against glioma [239]. Selenium is an important micronutrient with antioxidant capacity.…”

Section: Protective Roles Of Antioxidant-rich Diet In Brain Tumorsmentioning

confidence: 99%

Antioxidants in brain tumors: current therapeutic significance and future prospects

Jha

et al. 2022

Mol Cancer

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Brain cancer is regarded among the deadliest forms of cancer worldwide. The distinct tumor microenvironment and inherent characteristics of brain tumor cells virtually render them resistant to the majority of conventional and advanced therapies. Oxidative stress (OS) is a key disruptor of normal brain homeostasis and is involved in carcinogenesis of different forms of brain cancers. Thus, antioxidants may inhibit tumorigenesis by preventing OS induced by various oncogenic factors. Antioxidants are hypothesized to inhibit cancer initiation by endorsing DNA repair and suppressing cancer progression by creating an energy crisis for preneoplastic cells, resulting in antiproliferative effects. These effects are referred to as chemopreventive effects mediated by an antioxidant mechanism. In addition, antioxidants minimize chemotherapy-induced nonspecific organ toxicity and prolong survival. Antioxidants also support the prooxidant chemistry that demonstrate chemotherapeutic potential, particularly at high or pharmacological doses and trigger OS by promoting free radical production, which is essential for activating cell death pathways. A growing body of evidence also revealed the roles of exogenous antioxidants as adjuvants and their ability to reverse chemoresistance. In this review, we explain the influences of different exogenous and endogenous antioxidants on brain cancers with reference to their chemopreventive and chemotherapeutic roles. The role of antioxidants on metabolic reprogramming and their influence on downstream signaling events induced by tumor suppressor gene mutations are critically discussed. Finally, the review hypothesized that both pro- and antioxidant roles are involved in the anticancer mechanisms of the antioxidant molecules by killing neoplastic cells and inhibiting tumor recurrence followed by conventional cancer treatments. The requirements of pro- and antioxidant effects of exogenous antioxidants in brain tumor treatment under different conditions are critically discussed along with the reasons behind the conflicting outcomes in different reports. Finally, we also mention the influencing factors that regulate the pharmacology of the exogenous antioxidants in brain cancer treatment. In conclusion, to achieve consistent clinical outcomes with antioxidant treatments in brain cancers, rigorous mechanistic studies are required with respect to the types, forms, and stages of brain tumors. The concomitant treatment regimens also need adequate consideration.

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“…Meta-regression analysis showed that higher tea consumption was related to a reduced glioma risk (RR = 0.84, 95% CI = 0.71∼0.98, p = 0.030), and sensitivity study through removing case-control studies revealed that more consumption of tea was associated with lower risk of glioma (RR = 0.81, 95% CI = 0.70∼0.93, p = 0.004). Daily 1 cup of tea reduced the glioma risk by 3% (RR = 0.97, 95% CI = 0.94∼1.00, p = 0.048) ( 39 ).…”

Section: Epidemiological Evidence Of Anticarcinogenic Effects Of Tea ...mentioning

confidence: 99%

Anticarcinogenic potentials of tea catechins

Liu²,

Dong³

et al. 2022

Front. Nutr.

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Catechins are a cluster of polyphenolic bioactive components in green tea. Anticarcinogenic effects of tea catechins have been reported since the 1980s, but it has been controversial. The present paper reviews the advances in studies on the anticarcinogenic activities of tea and catechins, including epidemiological evidence and anticarcinogenic mechanism. Tea catechins showed antagonistic effects on many cancers, such as gynecological cancers, digestive tract cancers, incident glioma, liver and gallbladder cancers, lung cancer, etc. The mechanism underlying the anticarcinogenic effects of catechins involves in inhibiting the proliferation and growth of cancer cells, scavenging free radicals, suppressing metastasis of cancer cells, improving immunity, interacting with other anticancer drugs, and regulating signaling pathways. The inconsistent results and their causes are also discussed in this paper.

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Coffee and tea consumption and the risk of glioma: a systematic review and dose–response meta-analysis

Cited by 18 publications

References 38 publications

Dietary Factors and Risk of Glioma in Adults: A Systematic Review and Dose-Response Meta-Analysis of Observational Studies

Dietary Factors and Risk of Glioma in Adults: A Systematic Review and Dose-Response Meta-Analysis of Observational Studies

Antioxidants in brain tumors: current therapeutic significance and future prospects

Anticarcinogenic potentials of tea catechins

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