Coffee consumption and risk of localized, advanced and fatal prostate cancer: a population-based prospective study

Discacciati, Andrea; Orsini, Nicola; Andersson, Swen‐Olof; Andrén, Ove; Johansson, Jan‐Erik; Mantzoros, Christos S.; Wolk, Alicja

doi:10.1093/annonc/mdt105

Cited by 32 publications

(44 citation statements)

References 35 publications

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“…[5][6][7][28][29][30][31][32]38 The results from the subgroup analysis showed a strong inverse association between coffee consumption and fatal or high-grade prostate cancer risk, suggesting that coffee may be implicated in preventing progression of prostate cancer. A recent study indicated that higher prediagnostic coffee consumption was associated with a lower risk of prostate cancer recurrence/progression.…”

Section: Discussionmentioning

confidence: 99%

“…11 If a study provided separate OR or RR estimates by age or subtype of the disease, we treated them as different studies. 6,12 Risk estimates were extracted from each study, and log RRs were weighted by the inverse of their variances to obtain a pooled RR and its 95% CI. For each study, non/lowest drinkers represented the reference category, highest drinkers represented the greatest coffee consumption, moderate drinkers represented in-between coffee consumption and ever drinkers represented both greatest and moderate coffee consumption.…”

Section: Methodsmentioning

confidence: 99%

“…[5][6][7]11,12,[21][22][23][24][25][26][29][30][31][33][34][35]38 Statistically significant departure from linearity was found for all studies (P ¼ 0.04; Figure 3a), but not for cohort studies (P ¼ 0.07; Figure 3b) and case-control studies (P ¼ 0.38). A 2 cups/day increment in coffee consumption level conferred an RR of 0.97 (95% CI ¼ 0.94-1.01) for overall result, 0.93 (95% CI ¼ 0.88-0.99) for cohort studies and 1.04 (95% CI ¼ 1.00-1.08) for case-control studies.…”

Section: Evidence Synthesismentioning

confidence: 99%

“…3,4 However, the reduced risk of prostate cancer in coffee drinkers was observed in several studies. [5][6][7] A meta-analysis, 8 including the results of eight case-control studies and four cohort studies, found an overall relative risk (RR) of 1.16 (95% confidence interval (CI) ¼ 1.01-1.33) for highest vs lowest coffee drinkers, but the combination of four cohort studies demonstrated no association (RR ¼ 1.06; 95% CI ¼ 0.83-1.35). Another meta-analysis, 9 combining five cohort studies, showed an inverse association of prostate cancer risk with high coffee intake (RR ¼ 0.79; 95% CI ¼ 0.61-0.98).…”

Section: Introductionmentioning

confidence: 99%

“…Values in bold font indicate statistical significance (Po0.05). a If a study provided separate OR or RR estimates by age or subtype of the disease, we treated them as different studies 6,12. …”

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confidence: 99%

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Coffee consumption and risk of prostate cancer: an up-to-date meta-analysis

Zhong

Chen

et al. 2013

Eur J Clin Nutr

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Evidence Synthesismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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confidence: 99%

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Coffee consumption and risk of prostate cancer: an up-to-date meta-analysis

Zhong

Chen

et al. 2013

Eur J Clin Nutr

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Coffee and tea consumption and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition

Sen

Papadimitriou

Λάγιου

et al. 2018

Intl Journal of Cancer

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The epidemiological evidence regarding the association of coffee and tea consumption with prostate cancer risk is inconclusive, and few cohort studies have assessed these associations by disease stage and grade. We examined the associations of coffee (total, caffeinated and decaffeinated) and tea intake with prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition. Among 142,196 men, 7,036 incident prostate cancer cases were diagnosed over 14 years of follow-up. Data on coffee and tea consumption were collected through validated country-specific food questionnaires at baseline. We used Cox proportional hazards regression models to compute hazard ratios (HRs) and 95% confidence intervals (CI). Models were stratified by center and age, and adjusted for anthropometric, lifestyle and dietary factors. Median coffee and tea intake were 375 and 106 mL/day, respectively, but large variations existed by country. Comparing the highest (median of 855 mL/day) versus lowest (median of 103 mL/day) consumers of coffee and tea (450 vs. 12 mL/day) the HRs were 1.02 (95% CI, 0.94-1.09) and 0.98 (95% CI, 0.90-1.07) for risk of total prostate cancer and 0.97 (95% CI, 0.79-1.21) and 0.89 (95% CI, 0.70-1.13) for risk of fatal disease, respectively. No evidence of association was seen for consumption of total, caffeinated or decaffeinated coffee or tea and risk of total prostate cancer or cancer by stage, grade or fatality in this large cohort. Further investigations are needed to clarify whether an association exists by different preparations or by concentrations and constituents of these beverages.

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Coffee and cancer risk, epidemiological evidence, and molecular mechanisms

Bøhn

Blomhoff

Paur

2013

Molecular Nutrition Food Res

142

105

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Although early studies suggested that coffee consumption might increase risk of some cancers, more comprehensive epidemiological and experimental data now generally indicate either neutral or beneficial effects. In this review, we summarize the current evidence for associations between breast, prostate, colorectal, and liver cancers and the consumption of coffee, and discuss the experimental evidence for potential chemopreventive mechanisms of coffee and coffee constituents. The epidemiological evidence consistently indicates that coffee protects against liver cancer, and also point toward protective effects for risk of colorectal cancers (with relative risks of 0.50 (95% CI: 0.42-0.59) and 0.83 (95% CI: 0.75-0.92), respectively, in the most recent meta-analyses). There seems to be no association between the overall risk of breast and prostate cancer and coffee intake. However, for subgroups such as postmenopausal breast cancers, advanced prostate cancers, and breast and prostate cancer survivors, an inverse association with coffee intake is indicated. Potential mechanisms for chemopreventive effects of coffee phytochemicals includes inhibition of oxidative stress and oxidative damage, regulation of DNA repair, phase II enzymatic activity, apoptosis, inflammation, as well as having antiproliferative, antiangiogenetic effects and antimetastatic effects. The experimental evidence for effects of coffee and coffee constituents on each of these processes is discussed.

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Coffee consumption and risk of localized, advanced and fatal prostate cancer: a population-based prospective study

Abstract: We observed a clear inverse association between coffee consumption and risk of localized PCa, especially among overweight and obese men.

Cited by 32 publications

References 35 publications

Coffee consumption and risk of prostate cancer: an up-to-date meta-analysis

Coffee consumption and risk of prostate cancer: an up-to-date meta-analysis

Coffee and tea consumption and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition

Coffee and cancer risk, epidemiological evidence, and molecular mechanisms

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