Coffee consumption and risk of renal cell carcinoma

Abstract

Background Studies have suggested an inverse association between coffee consumption and risk of renal cell carcinoma (RCC); however, data regarding decaffeinated coffee are limited. Methods We conducted a case-control study of 669 incident RCC cases and 1,001 frequency-matched controls. Participants completed identical risk factor questionnaires that solicited information usual coffee consumption habits, and they were categorized as non-coffee, caffeinated coffee, decaffeinated coffee, or both caffeinated and decaffeinated coffee drinkers. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using logistic regression, adjusting for multiple risk factors for RCC. Results Compared with no coffee consumption, we found an inverse association between caffeinated coffee consumption and RCC risk (OR=0.74; 95% CI=0.57–0.99), whereas we observed a trend toward increased risk of RCC for consumption of decaffeinated coffee (OR=1.47; 95% CI=0.98–2.19). Furthermore, decaffeinated coffee consumption was associated with increased risk of the clear cell RCC (ccRCC) subtype, particularly the aggressive form of ccRCC (OR=1.80; 95%CI=1.01–3.22). Conclusions Consumption of caffeinated coffee is associated with reduced risk of RCC, while decaffeinated coffee consumption was associated with an increase in risk of aggressive ccRCC. Further inquiry is warranted in large prospective studies and should include assessment of dose-response associations.

Renal cell carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

“…Beyond well-known risk factors for RCC, such as cigarette smoking, obesity and hypertension, evidence is accumulating to suggest an aetiological or, on the contrary, a protective role, for additional factors [2], such as trichloroethylene. In a recently published case control study of 699 RCC patients and 1001 frequency-matched controls, consumption of caffeinated coffee was found to be associated with reduced risk of RCC; interestingly, decaffeinated coffee was associated with an increased risk for aggressive clear cell RCC (ccRCC) [3].…”

Caffeine Targets G6PDH to Disrupt Redox Homeostasis and Inhibit Renal Cell Carcinoma Proliferation

“…Caffeine (1,3,7-trimethylxanthine), a naturally occurring plant xanthine alkaloid found in tea, coffee, cocoa, and many other food products, has been shown to possess numerous biological functions ( Xu et al, 2019 ). A previous case–control study concluded that caffeine consumption can reduce the risk of developing RCC ( Antwi et al, 2017 ). However, whether caffeine can affect RCC development and progression remains unknown.…”

Zalecenia Postępowania Diagnostyczno-Terapeutycznego W Raku Nerkowokomórkowym

“…The exact etiology of sporadic RCC has not been established, however, a higher incidence of RCC has been associated with nicotinism, obesity, and hyperten-sion. In turn, consumption of coffee containing caffeine reduces the risk of RCC, and decaffeinated coffee increases the risk of developing clear cell RCC [4]. Renal cell carcinoma is also more common in patients with chronic kidney disease, dialyzed, undergoing kidney transplantation or in patients with tuberous sclerosis complex (TSC).…”