Coffee consumption and serum aminotransferases in middle-aged Japanese men

Honjo, Satoshi; Kono, Suminori; Coleman, Michel P; Shinchi, Koichi; Sakurai, Yoshinori; Todoroki, Isao; Umeda, Takashi; Wakabayashi, Kazuo; Imanishi, Koji; Nishikawa, Hiroshi; Ogawa, Shinsaku; Katsurada, Mitsuhiko; Nakagawa, Katsuya; Yoshizawa, Nobuyuki

doi:10.1016/s0895-4356(01)00344-4

Cited by 99 publications

(70 citation statements)

References 21 publications

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“…36 Other components of coffee, including caffeine and antioxidant substances from coffee beans, have been related to favorable modifications in liver enzymes such as ␥-glutamyltransferase and aminotransferase activities. [1][2][3][4] Coffee has also been related to reduced risk of liver disease and cirrhosis, 14-18,37 a major risk factor or pathogenic step in the process of liver carcinogenesis. [11][12][13] The beneficial effect of coffee consumption on HCC may be due to its inverse relation with cirrhosis, although allowance for clinical history of cirrhosis did not totally account for the inverse association.…”

Section: Discussionmentioning

confidence: 99%

“…1 Coffee consumption has been inversely related to ␥-glutamyltransferase and aminotransferase activity in studies from Europe, Japan, and the United States. [1][2][3][4] Such inverse relations are stronger in high-risk subjects, particularly in heavy drinkers. 1,[5][6][7][8][9][10] Coffee drinking has also been inversely related to the risk of cirrhosis-a major correlate of HCC [11][12][13] -in studies from North America and Europe.…”

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confidence: 98%

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Coffee drinking and hepatocellular carcinoma risk

et al. 2007

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Several studies suggest an inverse relation between coffee drinking and risk of hepatocellular carcinoma (HCC). We conducted a meta-analysis of published studies on HCC that included quantitative information on coffee consumption. Ten studies were retrieved (2,260 HCC cases), including 6 case-control studies from southern Europe and Japan (1551 cases) and 4 cohort studies from Japan (709 cases). The summary relative risk (

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 98%

Coffee drinking and hepatocellular carcinoma risk

et al. 2007

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“…Coffee has a favorable effect on liver function and liver diseases, particularly in high-risk individuals, making it a substance of interest for the prevention of HCC [104][105][106][107][108][109][110][111][112][113].…”

Section: Coffeementioning

confidence: 99%

Asian Pacific Association for the Study of the Liver consensus recommendations on hepatocellular carcinoma

et al. 2010

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Introduction The Asian Pacific Association for the Study of the Liver (APASL) convened an international working party on the management of hepatocellular carcinoma (HCC) in December 2008 to develop consensus recommendations. Methods The working party consisted of expert hepatologist, hepatobiliary surgeon, radiologist, and oncologist from Asian-Pacific region, who were requested to make drafts prior to the consensus meeting held at Bali, Indonesia on 4 December 2008. The quality of existing evidence and strength of recommendations were ranked from 1 (highest) to 5 (lowest) and from A (strongest) to D (weakest), respectively, according to the Oxford system of evidence-based approach for developing the consensus statements. 123Hepatol Int (2010) 4: 439-474 DOI 10.1007/s12072-010-9165-7 Results Participants of the consensus meeting assessed the quality of cited studies and assigned grades to the recommendation statements. Finalized recommendations were presented at the fourth APASL single topic conference on viral-related HCC at Bali, Indonesia and approved by the participants of the conference.

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“…Aspartate aminotransferase (AST) seems to be a primary marker for hepatocellular injury (Stewart 2002), because it is more specific than other liver enzymes for detecting alcohol-induced hepatocyte necrosis (Cohen and Kaplan 1979). Although some information has been developed as to the relationships between alcohol consumption and either AST or alanine aminotransferase (ALT) (Steffensen et al 1997;Arndt et al 1998;Nagaya et al 1999;Honjo et al 2001;Lee et al 2001;Stewart 2002), the threshold of alcoholassociated AST (or ALT) elevation remains controversial.…”

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confidence: 99%

Effects of Alcohol Consumption on Hepatocellular Injury in Japanese Men

Dakeishi

Iwata

Ishii

et al. 2004

Tohoku J. Exp. Med.

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To clarify the effects of alcohol consumption on hepatocellular injury, we examined aspartate and alanine aminotransferases (AST and ALT), and -glutamyltransferase (GGT), together with weekly alcohol consumption calculated from a self-rating questionnaire, in 1113 Japanese salesmen. The thresholds of associations between alcohol consumption and liver markers were estimated by the benchmark dose (BMD) method. The AST, ALT and GGT were positively correlated with alcohol intake (p<0.001), as well as age and body mass index (BMI); the relations to alcohol were statistically significant even when controlling for age, BMI and smoking habit. Although the AST and GGT were associated with four types of alcoholic beverage (p<0.01), it was only whisky that had close relation to the ALT (p<0.05). The thresholds of alcohol consumption (ethanol g/week), i.e., 95% lower confidence limits of the BMD, were 362 for AST, 660 for ALT, and 252 for GGT. The thresholds for GGT and AST in Japanese men seem to be somewhat higher than those reported in Western countries. It is suggested that hepatocellular injury (i.e., AST elevation) in Japanese men may emerge at the ethanol level of more than 50 g/day. alcohol consumption; hepatocellular injury; aspartate aminotransferase (AST); benchmark dose method; critical dose

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Coffee consumption and serum aminotransferases in middle-aged Japanese men

Cited by 99 publications

References 21 publications

Coffee drinking and hepatocellular carcinoma risk

Coffee drinking and hepatocellular carcinoma risk

Asian Pacific Association for the Study of the Liver consensus recommendations on hepatocellular carcinoma

Effects of Alcohol Consumption on Hepatocellular Injury in Japanese Men

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