Effects of Alcohol Consumption on Hepatocellular Injury in Japanese Men

Dakeishi, Miwako; Iwata, Tetsu; Ishii, Noriko; Murata, Katsuyuki

doi:10.1620/tjem.202.31

Cited by 23 publications

(20 citation statements)

References 25 publications

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“…Recently Dakeishi et al reported that hepatocellular injury, as indicated by elevation of AST could emerge only when the alcohol intake is >50 gm/day. [19] This concurs well with our findings where the mean alcohol consumption was 300 g/day and AST levels were also elevated significantly. The AST appears to be the primary marker of hepatocellular injury because it is more specific than other liver enzymes for detecting alcohol induced diseases.…”

Section: Discussionsupporting

confidence: 93%

Biochemical measures in the diagnosis of alcohol dependence using discriminant analysis

Vaswani¹,

Rao²

2005

Indian J Med Sci

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Section: Discussionsupporting

confidence: 93%

Biochemical measures in the diagnosis of alcohol dependence using discriminant analysis

Vaswani¹,

Rao²

2005

Indian J Med Sci

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“…A total of 100% ethanol equivalent dose (g/wk) was calculated for each subject, using a questionnaire reported previously 11) . In the solvent workers, concentrations of toluene, xylene, styrene, and n-hexane were measured using passive gas samplers (Sibata Co., Japan) worn through the day, and were estimated as 8-h time-weighted average concentration (ppm) by gas chromatograph mass spectrometry (Qmass910 Mass Spectrometer; Perkin Elmer Inc., USA) with Spelcowax 10 column separation and single ion monitoring detection.…”

Section: Methodsmentioning

confidence: 99%

Effects of Mixed Organic Solvents on Neuromotor Functions among Workers in Buddhist Altar Manufacturing Factories

Iwata

Mori²,

Dakeishi

et al. 2005

Journal of Occupational Health

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Effects of Mixed Organic Solvents on Neuromotor Functions among Workers in BuddhistAltar Manufacturing Factories: Toyoto IWATA, et al. Department of Environmental Health Sciences, Akita University School of Medicine-To clarify the neuromotor effects of long-term exposure to mixed organic solvents, postural sway and tremor were measured in 62 solvent workers of four Buddhist altar manufacturing factories who had worked for 1-46 (mean 12) yr. By using the passive gas sampler, 8-h time-weighted average concentrations in the workers were estimated to be 0.02-8.7 ppm for toluene, 0.02-7.7 ppm for xylene, 0.02-5.5 ppm for styrene and 0.02-40.5 ppm for n-hexane. Sagittal sway and sway area of the posturography with eyes closed were significantly larger in the solvent workers than in 35 age-matched controls (p<0.05), and there was a significant difference in Romberg quotient of sagittal sway between the two groups (p<0.05). Also, tremor intensities at 1.0-5.9 Hz, 6.0-9.9 Hz and 10.0-13.9 Hz with the right hand, and at 6.0-9.9 Hz with the left hand were significantly stronger in the solvent workers than in the controls. Among the solvent workers, transversal and sagittal sways with eyes open and tremor intensity at 10.0-13.9 Hz were significantly related to toluene exposure (p<0.05), which may have been due to the acute effects of such solvents. These findings suggest that longterm exposure to mixed organic solvents may impair neuromotor functions as measured by postural sway and tremor. (J Occup Health 2005; 47: 143-148)

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“…For ethanol, BMD modelling results from long‐term animal experiments as well as from large human epidemiological studies are available in the literature (Table ) . We additionally provide BMD modelling of a study on breast cancer .…”

Section: Resultsmentioning

confidence: 99%

Can resveratrol in wine protect against the carcinogenicity of ethanol? A probabilistic dose‐response assessment

Lachenmeier

Godelmann

Witt

et al. 2013

Intl Journal of Cancer

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Resveratrol, which may occur in wine, was suggested to act as a chemopreventive agent against the carcinogenic effects of ethanol. The assumption was based on data from experimental animals, which have shown that resveratrol above certain thresholds may reduce the incidence of tumours in several of the alcohol‐related cancer sites (colon, liver and female breast). Using a probabilistic Monte Carlo type methodology, we estimated daily intake based on chemical analysis of resveratrol (n = 672) and ethanol (n = 867). Benchmark dose (BMD)‐response modelling was conducted for resveratrol based on eight animal experiments, whereas BMD data for ethanol were taken from the literature. The margin of exposure (MOE) was calculated for both substances as an indicator if the intake may reach effective dosages. For intake of one 100‐mL glass of wine, the average MOE was found to be 4.1 for ethanol and 459,937 for resveratrol. In the best‐case scenario for resveratrol (e.g., very high contents and assuming a low effective dosage), the minimum MOE would be 111, which means that 111 glasses of wine need to be consumed daily to reach the BMD. The MOE ratio between resveratrol and ethanol is 166,128 on average, meaning that per glass of wine, ethanol is more than 100,000 times more potent than resveratrol. As resveratrol intake may not optimally reach the effective dosage, our study excludes a preventive effect of this substance on alcohol‐related cancer. Commercial information about cancer‐preventive or ‐protective effects of resveratrol in wine is misleading and must be prohibited.

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Effects of Alcohol Consumption on Hepatocellular Injury in Japanese Men

Cited by 23 publications

References 25 publications

Biochemical measures in the diagnosis of alcohol dependence using discriminant analysis

Biochemical measures in the diagnosis of alcohol dependence using discriminant analysis

Effects of Mixed Organic Solvents on Neuromotor Functions among Workers in Buddhist Altar Manufacturing Factories

Can resveratrol in wine protect against the carcinogenicity of ethanol? A probabilistic dose‐response assessment

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