Coffee in the cornflakes: time-of-day as a modulator of executive response control

Manly, Tom; Lewis, Geraint; Robertson, Ian H.; Watson, Peter; Datta, Avijit

doi:10.1016/s0028-3932(01)00086-0

Cited by 136 publications

(80 citation statements)

References 30 publications

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“…Errors have been interpreted as indicating impaired sustained attention. The SART discriminates ADHD cases from controls (Shallice et al, 2002), and depressed from non-depressed men (Farrin et al, 2003), correlates with other tests of sustained attention (Robertson et al, 1997), time-of-day (Manly et al, 2000) and subjective sleepiness (Manly et al, 2002), and is sensitive to acute pharmacological challenges (Sofuoglu et al, 2008). 225 single digits (25 × 9 digits) are presented on a computer monitor for 250 ms each, immediately followed by a mask for 900 ms.…”

Section: Methodsmentioning

confidence: 80%

Disulfiram enhances subjective effects of dextroamphetamine in humans

Sofuoglu

Poling

Waters

et al. 2008

Pharmacology Biochemistry and Behavior

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Disulfiram has shown promise in several clinical trials for cocaine addiction, but its potential utility in the treatment of amphetamine addiction has not been examined. The goal of this study was to determine the effects of disulfiram on acute physiological and subjective responses to dextroamphetamine in healthy volunteers. Five male and 5 female subjects participated in an outpatient double-blind, placebo-controlled, crossover study. Subjects were randomly assigned to a sequence of disulfiram (250 mg/day) or placebo treatments each lasting for 4 days. Day four of each treatment period was the experimental session, in which subjects orally ingested a single dose of dextroamphetamine (20 mg/70 kg). Outcome measures included heart rate, blood pressure, plasma cortisol and prolactin, subjective and performance on the Sustained Attention to Response Test (SART). Disulfiram did not affect dextroamphetamine-induced increases in heart rate, blood pressure, cortisol, or prolactin. Disulfiram did enhance some of the subjective effects of dextroamphetamine including ratings of "high," "anxious," "bad drug effects," "want more drug" and "drug liking" and was also associated with decreased performance in the SART test. How these enhanced subjective amphetamine responses affect cocaine use behavior remains to be determined in future clinical trials.Disulfiram enhances subjective effects of dextroamphetamine in humans. Amphetamine abuse, especially methamphetamine, is an important public health problem in the US, with an estimated 1.4 million have reported methamphetamine use during the past year (SAMHSA, 2004). There are no approved pharmacotherapies for the treatment of amphetamine (Hill and Sofuoglu, 2007) or cocaine addiction, the other commonly used stimulant (Sofuoglu and Kosten, 2006). Given the similarities between the pharmacological effects of cocaine and amphetamines (Fischman et al., 1976), it is plausible that potential pharmacotherapies may be effective for both cocaine and amphetamine addiction. One of the promising medications for cocaine addiction is disulfiram (Antabuse), which has been shown to reduce cocaine abuse and relapse in outpatient clinical trials (Carroll et al., 1993;Carroll et al., 2004;Carroll et al., 1998;George et al., 2000;Petrakis et al., 2000). Disulfiram is approved by the Food and Drug Mehmet Sofuoglu, Yale University, Department of Psychiatry, VA Connecticut Healthcare System, 950 Campbell Ave., Bldg. 36/116A4, West Haven, CT 06516, Phone: (203) Fax: (203) 937-3478, e-mail: Mehmet.Sofuoglu@yale.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the j...

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Section: Methodsmentioning

confidence: 80%

Disulfiram enhances subjective effects of dextroamphetamine in humans

Sofuoglu

Poling

Waters

et al. 2008

Pharmacology Biochemistry and Behavior

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“…A recent study by Manly, Lewis, Robertson, Watson, and Datta ( 2002 ) examined the effects of circadian modulation on the SART in students. They found signifi cantly higher errors of commission at 1 a.m. and 7 a.m. compared with 1 p.m. and 7 p.m. No circadian modulation of the more routine aspects of the task were observed.…”

Section: Attention Defi Cits Associated With Sleep In Healthy Adultsmentioning

confidence: 99%

Do sleep difficulties exacerbate deficits in sustained attention following traumatic brain injury?

Bloomfield

Espie

Evans

2009

J Int Neuropsychol Soc

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Sustained attention has been shown to be vulnerable following traumatic brain injury (TBI). Sleep restriction and disturbances have been shown to negatively affect sustained attention. Sleep disorders are common but under-diagnosed after TBI. Thus, it seems possible that sleep disturbances may exacerbate neuropsychological defi cits for a proportion of individuals who have sustained a TBI. The aim of this prospective study was to examine whether poor sleepers post-TBI had poorer sustained and general attentional functioning than good sleepers post-TBI. Retrospective subjective, prospective subjective, and objective measures were used to assess participants' sleep. The results showed that the poor sleep group had signifi cantly poorer sustained attention ability than the good sleep group. The differences on other measures of attention were not signifi cant. This study supports the use of measures that capture specifi c components of attention rather than global measures of attention, and highlights the importance of assessing and treating sleep problems in brain injury rehabilitation. ( JINS , 2010, 16, 17-25.)

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“…It is known that healthy ageing is associated with weakened circadian rhythms, leading to a lessened demarcation between activity in the ''day'' phase and sleep in the ''night'' phase, dampened circadian amplitude but unaffected circadian period, phase advances and weakened entrainment to zeitgebers (Hofman and Swaab 2006). As there are circadian rhythms in cognitive domains such as attention, working and episodic memory and executive function (Manly et al 2002;Schmidt et al 2007), it may be the case that in healthy ageing weakened circadian function is a factor in cognitive decline. In the course of neurodegenerative conditions, such Alzheimer's disease, this deterioration in circadian timekeeping is significantly exacerbated (Thome et al 2011;Wu and Swaab 2007), and this may contribute to significant behavioural problems such as sundowning (Bachman and Rabins 2006).…”

Section: Introductionmentioning

confidence: 99%