Cognition in a multiple system atrophy series of cases from Argentina

Gatto, Emilia; Demey, Ignacio; Sanguinetti, A; Parisi, Virginia; Etcheverry, José Luis; Rojas, Galeno; Wenning, Gregor K.

doi:10.1590/0004-282x20140127

Cited by 12 publications

(12 citation statements)

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“…So far, few studies have addressed the possible differences between patients with predominant cerebellar or parkinsonian presentation, and the focus has been mainly on MSA‐P patients. In this study, a comparison of raw scores revealed lower performance of MSA‐C patients than MSA‐P patients in a screening of executive functions and in phonological verbal fluency.…”

Section: Discussionmentioning

confidence: 99%

“…Nonetheless, there are conflicting results and heterogeneous data have been published regarding the differences between MSA‐C and MSA‐P. Previous studies suggested a comparable performance, a more prominent decline of executive function and verbal memory in MSA‐C or a more pronounced cognitive dysfunction in MSA‐P …”

Section: Discussionmentioning

confidence: 99%

“…7 Although this was beyond the scope of the following study and therefore has not been assessed, these major distinctive features are usually not present in patients with MSA. 7 So far, few studies have addressed the possible differences between patients with predominant cerebellar or parkinsonian presentation, [12][13][14][15][16][17] and the focus has been mainly on MSA-P patients. In this study, a comparison of raw scores revealed lower performance of MSA-C patients than MSA-P patients in a screening of executive functions and in phonological verbal fluency.…”

Section: Discussionmentioning

confidence: 99%

“…have been conducted but reported heterogeneous results. 8,[12][13][14][15][16][17] Kawai and colleagues observed a multidomain cognitive decline in MSA-P but not in MSA-C. 12 Another study reported a more pronounced executive and verbal memory dysfunction in MSA-C, 14 and a third found comparable cognitive profiles in both variants. 8 Cognitive deficits in MSA may be explained by underlying degeneration of basal ganglia and to secondarily disrupted striato-pallido-thalamocortical circuits.…”

Section: Introductionmentioning

confidence: 98%

“…In contrast, severe cognitive decline that significantly disrupts daily living is uncommon in MSA; hence, dementia has been regarded as a nonsupporting feature in the current diagnostic criteria . Comparative studies on cognitive impairment in both motor subtypes have been conducted but reported heterogeneous results . Kawai and colleagues observed a multidomain cognitive decline in MSA‐P but not in MSA‐C .…”

Section: Introductionmentioning

confidence: 99%

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Cognition in multiple system atrophy: a single‐center cohort study

Eschlböck

Delazer

Krismer

et al. 2020

Ann Clin Transl Neurol

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Objective Cognitive impairment in multiple system atrophy (MSA) is common, but remain poorly characterized. We evaluated cognitive and behavioral features in MSA patients and assessed between‐group differences for MSA subtypes and the effect of orthostatic hypotension (OH) on cognition. Methods This retrospective study included 54 patients with clinical diagnosis of possible and probable MSA referred to the Department of Neurology at Medical University of Innsbruck between 2000 and 2018. Neurological work‐up included comprehensive neuropsychological testing including Consortium to Establish a Registry for Alzheimer's Disease (CERAD‐plus) test battery, Frontal Assessment Battery (FAB), digit span test (DST), clock drawing task (CLOX1), and Hospital Anxiety and Depression Scale (HADS‐D). Results The mean MMSE score was 27.6 points. Overall, slight to moderate cognitive impairment was noted in up to 40% of patients, with predominant impairment of executive function and verbal memory. Patients with the cerebellar variant performed significantly worse than patients with the parkinsonian type (P < 0.05) in a screening of executive functions (FAB) and in phonemic verbal fluency. Depression and anxiety scores were elevated in 28% and 22% of MSA patients, respectively. Cognitive profile, depression, and anxiety levels were comparable between patients with and without OH. Interpretation Cognitive deficits are relatively frequent in MSA and primarily affect executive functions and verbal memory. Future comparative studies including Parkinson dementia, Lewy body disease, and MSA cases with and without OH are required to elucidate disease‐specific cognitive profiles in these synucleinopathies and to examine the influence of cardiovascular autonomic dysfunction on cognitive function in MSA.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%