Cognitive, Affective, and Behavioral Dimensions of the Lower Urinary Tract Symptom Experience in Men With Parkinson's Disease

Moriarty, Helene; Robinson, Jennifer; Bunting-Perry, Lisette; Bradway, Christine

doi:10.1097/won.0000000000000165

Cited by 12 publications

(4 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Regarding the iADL function, no difference defining the status of PD-UU was found. Previous studies have shown that the presence and severity of urinary symptoms might have the potential to alter patients' everyday behavior, mainly due to the withdrawal of their social activities (Moriarty et al, 2016). Based on the assessment of the FAQ and the ADL subscale of the PDQ-39, we were not able to support these previous results (Liu et al, 2015).…”

Section: Discussioncontrasting

confidence: 59%

“…Urinary urgency is a common non-motor symptom (NMS) in Parkinson's disease (PD;Campos-Sousa et al, 2003;Winge and Fowler, 2006;McDonald et al, 2017). Presence of urinary urgency in PD (PD-UU) lowers patients' health-related quality of life (HRQoL; Liu et al, 2015;Moriarty et al, 2016) and its frequency is higher as among older healthy individuals (Khoo et al, 2013;Serra et al, 2018). To date, no effective treatment of PD-UU exists.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Executive Function Is Related to the Urinary Urgency in Non-demented Patients With Parkinson’s Disease

Tkaczynska

Becker

Maetzler

et al. 2020

Front. Aging Neurosci.

View full text Add to dashboard Cite

Introduction: Evidence suggests urinary urgency is associated with cognitive impairment in a subtype of Parkinson's disease (PD) patients. This study investigates if cognitive impairment independently predicts the presence of urinary dysfunction. Methods: We report data of 189 idiopathic PD patients, excluding those with concomitant diseases or medication interacting with bladder function. A standardized questionnaire was used to define the presence of urinary urgency. All patients underwent a comprehensive motor, cognitive non-motor and health-related quality of life (HRQoL) assessment. Multivariable linear regression analysis was performed to identify independent variables characterizing urinary urgency in PD (PD-UU), which were assigned as discriminant features to estimate their individual contribution to the phenotype of the PD-UU group. Results: Of 189 PD patients, 115 (60.8%) reported PD-UU. The linear regression analysis showed that among cognitive domains, executive function (EF; p = 0.04) had a significant negative association with PD-UU. In a second model, scores of the Montreal Cognitive Assessment (MoCA) significantly differentiated between study groups (p = 0.007) and also non-motor symptom (NMS) burden (p < 0.001). The third model consisted of reports of HRQoL, of which stigma was the only subscale of the Parkinson's Disease Questionnaire (PDQ-39) differentiating between patients with and without PD-UU (p = 0.02). The linear discriminant analysis provided evidence that the combination of EF, NMS burden, nocturia, and stigma discriminated between groups with 72.4% accuracy. Conclusion: In our large, non-demented PD cohort, urinary urgency was associated with executive dysfunction (EF), supporting a possible causative link between both symptoms. A combination of neuropsychological and non-motor aspects identified patients with PD-UU with high discriminative accuracy.

show abstract

Section: Discussioncontrasting

confidence: 59%

Section: Introductionmentioning

confidence: 99%

Executive Function Is Related to the Urinary Urgency in Non-demented Patients With Parkinson’s Disease

Tkaczynska

Becker

Maetzler

et al. 2020

Front. Aging Neurosci.

View full text Add to dashboard Cite

show abstract

“…Serra et al emphasized the profound impact of bowel and bladder symptoms on health‐related quality of life in PD patients, imposing even greater burden than motor and other non‐motor symptoms. Findings from our qualitative descriptive study of men with idiopathic PD and self‐reported LUTS ( N = 14) support this assertion . Our study yielded the following important considerations about the LUTS experience from the male patient's perspective: (a) limited awareness of the neurologic contributions of PD to LUTS; (b) the likelihood of embarrassment, bother, and negative effects on self‐esteem that jeopardize relationships, intimacy, participation in social activities, and travel; and (c) “do‐it‐yourself” management of LUTS with a focus on “being prepared to go when you need to go.” For example, one participant described a lifelong love of baseball and the joy of playing in a community league, which he gave up because there was no bathroom near the field and he feared being embarrassed by UI.…”

supporting

confidence: 55%

Increased odds of bladder and bowel symptoms in early Parkinson's disease

Robinson

Bradway

Bunting-Perry

et al. 2018

Neurourology and Urodynamics

Self Cite

View full text Add to dashboard Cite

We applaud your publication of the excellent paper by Serra et al 1 that presents evidence concerning the elevated prevalence of urinary incontinence (UI) in early Parkinson's disease (PD). Lower urinary tract symptoms (LUTS) are an important but often neglected issue in caring for PD patients, especially in early stages of the disease. We write to share findings from our research on LUTS in men with PD that: (a) resonate with those of Serra et al; (b) support existing literature on the impact of LUTS on quality of life in PD patients; and (c) highlight new information on the experience of providing care to male PD patients with LUTS.In the study by Serra et al, 1 UI was significantly more prevalent in a group of early PD patients (N = 423) than in a well-matched healthy control group (N = 195). Specifically, PD patients within 2 years of initial diagnosis were four times more likely to report UI than their counterparts in the healthy control group. In our work, 2 we were surprised by the prevalence of any LUTS (40%) and UI in particular (24%) in a retrospective study of baseline data from the healthcare records of 271 male patients with idiopathic PD enrolled in a movement disorder clinic at a large metropolitan Veterans Affairs Medical Center. Although baseline PD duration was greater among participants in our study (M = 7.1 years ± 6.3), most exhibited only mild disease and remained independent in activities of daily living at the time of clinic enrollment. Like Serra et al, we concluded that our findings most likely represented a conservative estimate of LUTS prevalence since, at the time of baseline data collection, LUTS were documented and explored by the provider only when triggered by a complaint from the patient. In a subsequent cross-sectional study in the same setting, we documented UI in 92% of our convenience sample of male patients (N = 88) with a similar PD duration (M = 8.3 years ± 6.1) and clinical profile. 3 We concluded that UI may be highly prevalent in the early symptomatic phase of PD, which challenges the conventional notion that LUTS only begin to appear in the early symptomatic phase. 4 Serra et al emphasized the profound impact of bowel and bladder symptoms on health-related quality of life in PD patients, imposing even greater burden than motor and other non-motor symptoms. Findings from our qualitative descriptive study of men with idiopathic PD and self-reported LUTS (N = 14) support this assertion. 5 Our study yielded the following important considerations about the LUTS experience from the male patient's perspective: (a) limited awareness of the neurologic contributions of PD to LUTS; (b) the likelihood of embarrassment, bother, and negative effects on self-esteem that jeopardize relationships, intimacy, participation in social activities, and travel; and (c) "do-ityourself" management of LUTS with a focus on "being prepared to go when you need to go." For example, one participant described a lifelong love of baseball and the joy of playing in a community league, which he gave up be...

show abstract

“…Symptoms were often related to a central disease process. For example, Moriarty, Robinson, Bunting‐Perry, and Bradway () explored lower urinary tract symptoms experienced by men with Parkinson's disease and Ensari et al. () focused on depressive symptoms in patients with multiple sclerosis.…”

Section: Resultsmentioning

confidence: 99%

An integrative review of the theory of unpleasant symptoms

Blakeman

2019

Journal of Advanced Nursing

View full text Add to dashboard Cite

Aims The aim of this study was to explore how the theory of unpleasant symptoms (TOUS) has been used in the methodological design and analysis of symptom research. Design An integrative review, using Whittemore and Knafl's approach. Data Sources Searches were conducted between 26 January–10 February 2018. Databases included CINAHL Complete, PubMed, Proquest Nursing and Allied Health Source, Health Source: Nursing/Academic Edition, Academic Search Complete and Google Scholar. Review Methods A systematic approach to searching, screening and analysing the literature was applied. The matrix method, content analysis, constant comparison, counting and clustering were used. Results Sixty‐four records were included. Most studies were quantitative, cross‐sectional, instrument‐based and conducted in the USA. Various symptoms and patient populations were represented and each of the TOUS concepts were explored. Conclusion Although the theory has a role to play in furthering symptom science, attention should be paid to the areas of the model and of symptom research that have received less attention. More complex statistical approaches and big data will help to illuminate symptom experiences. Additional focus on intervention studies and all symptom dimensions will help to advance symptom science research. Impact This review is the first to provide a comprehensive, systematic summary of the uses of the TOUS across the research literature to date. This theory is a diverse, holistic middle‐range theory capable of being applied to multiple symptoms and populations. Researchers should consider using the theory as a conceptual framework for studies to advance symptom science and explore symptoms holistically.

show abstract

Cognitive, Affective, and Behavioral Dimensions of the Lower Urinary Tract Symptom Experience in Men With Parkinson's Disease

Cited by 12 publications

References 26 publications

Executive Function Is Related to the Urinary Urgency in Non-demented Patients With Parkinson’s Disease

Executive Function Is Related to the Urinary Urgency in Non-demented Patients With Parkinson’s Disease

Increased odds of bladder and bowel symptoms in early Parkinson's disease

An integrative review of the theory of unpleasant symptoms

Contact Info

Product

Resources

About