Cognitive and Behavioral Interventions in Epilepsy

Leeman-Markowski, Beth A.; Schachter, Steven C.

doi:10.1007/s11910-017-0752-z

Cited by 43 publications

(31 citation statements)

References 66 publications

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“…Since epilepsy-associated cognitive decline can be found in new-onset epilepsy patients who have never received treatment, it is important to initially assess cognitive status of patients with epilepsy 7 . Early assessment and intervention slow down the progression of epilepsy-associated cognitive decline and maintain the functional capacity as well as the social function 8,9 . Nevertheless, this health problem as well as epilepsy per se have not been considered a priority by the health authorities in developing countries 10 .…”

Section: Introductionmentioning

confidence: 99%

Characteristics of Cognitive Status of Epilepsy Patients Treated With Monotherapy of First-Generation Antiepileptic Drugs

Harahap

Rizki

Nurfadia

et al. 2020

MJPHM

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Epilepsy is one of the main health problems in neurology that can lead to cognitive decline. Generally, the epilepsy-associated cognitive decline is influenced by demographic, clinical, and treatment characteristics. This study aimed to determine the characteristics of cognitive status of epilepsy patients who received monotherapy using first-generation antiepileptic drugs (AEDs), namely phenytoin, carbamazepine, and valproic acid. It involved 93 epilepsy patients of Mutiara Sukma Mental Hospital (n=38) and Mataram General Hospital (n=55). Besides, 93 healthy patients were assigned as healthy control group (HC) subjects (n=93). Demographic characteristics collected from epilepsy and HC groups were age, gender, and years of education. Clinical characteristics taken from both groups were MoCA-Ina score. Clinical characteristics taken from epilepsy group were age at epilepsy onset, type of seizure (partial vs generalized), etiology (idiopathic vs structural), first-generation AED used, years of treatment, and cognitive status. The result of the study revealed that there were no significant different between the two groups in the means of age and years of education as well as the frequency of male gender (p>0.05). The mean of MoCA-Ina score of epilepsy group was significantly lower compared with HC group (p<0.05). The frequency of cognitive decline among epilepsy patients was 75.3%. The cognitive functions of epilepsy patients using monotherapy with carbamazepine, phenytoin, or valproic acid was significantly lower compared with healthy subjects. We conclude that there was high prevalence of epilepsy-associated cognitive impairment which was associated with male gender.

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Section: Introductionmentioning

confidence: 99%

Characteristics of Cognitive Status of Epilepsy Patients Treated With Monotherapy of First-Generation Antiepileptic Drugs

Harahap

Rizki

Nurfadia

et al. 2020

MJPHM

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“…Epilepsy is a chronic neurological disorder with widespread presence (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). Out of approximately 70 million patients of epilepsy worldwide, about 12 million people suffer from epilepsy in India (5).…”

Section: Introductionmentioning

confidence: 99%

“…Several studies have analyzed the effect of meditation as an adjunct intervention for epilepsy patients, and have found encouraging results with regards to improving quality of life, and relieving stress, anxiety, depression, etc. (15)(16)(17) Since past several years, the Department of Ayurveda and Holistic Health (DAHH) at Dev Sanskriti Vishwavidyalaya, Haridwar, Uttarakhand has been practicing Yagyopathy, wherein different herbal preparations of Ayurvedic plant medicines (hawan samagri) have been made for various diseases such as those of digestive system (cholera, dysentery, etc. ), fevers (malaria, viral, etc.…”

Section: Introductionmentioning

confidence: 99%

Management of Epileptic Seizures through an Integrated Approach including Yagya Therapy

Mishra

Batham

Verma

et al. 2019

Interdis. J of Yagya Res.

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Background: Epileptic seizure is a neurological condition in which brief to long episodes of vigorous shaking, convulsions, blackouts, fainting, unresponsiveness, jerks, etc. occur in the patients. Current treatment approaches are anti-seizure medicines, which patients are bound to take throughout life. These medications are mostly not able to reverse or eradicate the condition. Purpose: As per the classical texts of Ayurveda, Apasmara is a disease that has similar symptoms as those found in epilepsy; it is of four types wherein either one of the three Doshas, i.e. Vata, Pitta, and Kapha, is predominantly vitiated, or there is an imbalance of all the three Doshas. Hence, the medicinal herbs that balance the respective doshas, are used in the Ayurvedic treatment of epileptic seizures. Various plant extracts or their derivatives have been found to be effective in the treatment of epilepsy. Yagya Therapy provides pulmonary inhalation of medicinal smoke of multiple herbs (generated through oblation in fire along with chanting of Vedic hymns), which have the potential for seizure treatment. Methods: A case report about a male patient, who was suffering from epileptic seizures since past 13 years, as well as other associated ailments has been presented in this article. The patient was prescribed an integrated approach including Yagya Therapy (using an appropriate herbal formulation - hawan samagri), and some other Ayurvedic treatments like decoction of medicinal herbs, Ayurvedic medicines, dietary restrictions, etc. Results: Before starting the integrated approach including Yagya Therapy, the patient used to experience seizure episodes, at least once every 7 to 10 days; however, after starting the integrated approach, the patient did not experience any seizure episode up to his second visit, i.e. for about 54 days. He also experienced relief in other associated ailments like vibration in the entire body. Conclusion: The integrated approach including Yagya Therapy showed encouraging results with regards to the treatment of epileptic seizures and other associated ailments.

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“…Noninvasive and nonpharmacologic interventions may be viable options for and preferred by many PWE due to their relatively low cost, reduced risk of side effects, and/or reduced potential interactions with antiseizure medications. 16 One possible strategy for improving cognition in PWE that has received little attention is increased physical activity and exercise. Only 1 small study to date has investigated the effects of exercise on cognition in PWE.…”

Section: Introductionmentioning

confidence: 99%

Role of Physical Activity and Exercise in Alleviating Cognitive Impairment in People With Epilepsy

Allendorfer

Arida

2018

Clinical Therapeutics

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Many persons with epilepsy (PWE) experience problems with a wide range of cognitive functions, including learning, memory, attention, and executive control. These deficits in cognition result in diminished quality of life for PWE and are related to many factors, including the etiology of their epilepsy, recurrent seizures, side effects of antiseizure medications, or a combination of these factors. Various treatments to ameliorate cognitive deficits experienced by PWE have been implemented, although noninvasive and nonpharmacologic strategies may be more appealing options due to their relatively low cost, reduced risk of side effects, and/or reduced potential interactions with antiseizure medications. Physical activity and exercise may improve cognition in PWE but have not been well researched in this respect. To date only 1 study has directly investigated the effects of exercise on cognition in PWE, and it showed improved performance on tests of attention and executive function. The goal of the present article was to examine how increased physical activity and exercise contributes to 3 strategies (reducing seizure frequency, reducing epileptiform discharges, and decreasing symptoms of depression) that have been described as having a positive impact on cognition in PWE, as well as highlight related findings in experimental models of epilepsy. There is a definite need for more randomized controlled trials to establish greater clinical evidence for the use of physical activity and exercise in ameliorating cognitive impairment in PWE. We also need to better understand the factors contributing to reduced physical activity in PWE, as well as ways to overcome such barriers. With the available research in the area of exercise in epilepsy showing positive results, and a supportive research climate encouraging PWE to engage in greater physical activity overall, further investigations into the relationships between physical activity and cognition in epilepsy are warranted.

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Cognitive and Behavioral Interventions in Epilepsy

Cited by 43 publications

References 66 publications

Characteristics of Cognitive Status of Epilepsy Patients Treated With Monotherapy of First-Generation Antiepileptic Drugs

Characteristics of Cognitive Status of Epilepsy Patients Treated With Monotherapy of First-Generation Antiepileptic Drugs

Management of Epileptic Seizures through an Integrated Approach including Yagya Therapy

Role of Physical Activity and Exercise in Alleviating Cognitive Impairment in People With Epilepsy

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