Cognitive and language functions of the human cerebellum

Leiner, Henrietta C.; Leiner, Alan L.; Dow, Robert S.

doi:10.1016/0166-2236(93)90072-t

Cited by 663 publications

(329 citation statements)

References 26 publications

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“…In addition to its well-known role in motor coordination, it also has been implicated in a variety of cognitive and affective functions (Leiner et al, 1993). These functions depend on precise interactions among at least five types of neurons named Purkinje cells, granule cells, Bergmann glia cells, Golgi cells, and Basket/Stellate cells (Wang and Zoghbi, 2001).…”

Section: Introductionmentioning

confidence: 99%

The expression pattern of nuclear receptors during cerebellar development

Qin

Suh

Kim

et al. 2007

Developmental Dynamics

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Section: Introductionmentioning

confidence: 99%

The expression pattern of nuclear receptors during cerebellar development

Qin

Suh

Kim

et al. 2007

Developmental Dynamics

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“…It has been implicated in the planning, execution and control of motor actions as well as, more controversially, in a number of cognitive functions [8][9][10] . Cerebellar systems are of interest because recent evidence suggests that they have expanded in some groups of primates 11 .…”

Section: Introductionmentioning

confidence: 99%

The evolution of the cortico-cerebellar complex in primates: anatomical connections predict patterns of correlated evolution

Whiting

Barton

2003

Journal of Human Evolution

132

134

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The full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-pro t purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. AbstractInvestigations into the evolution of the primate brain have generally neglected the role of connectivity in determining which brain structures have changed in size, focussing instead on changes in the size of the whole brain or of individual brain structures, such as the neocortex, in isolation. We show that the primate neocortex, cerebellum and vestibular nuclei exhibit correlated volumetric evolution. At a relatively fine-grained level of resolution, the evolutionary correlations correspond to known patterns of connectivity among these structures (amongst specific nuclei, for example). These results support the idea that brains evolved by mosaic size change in arrays of connected structures. Furthermore, they suggest that the much discussed expansion of the primate neocortex should be re-evaluated in the light of conjoint cerebellar expansion.Whiting & Barton 3

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“…Efferents from similar cerebellar areas project via the dentate nucleus to the thalamus, among others, partly terminating upon mediodorsal thalamic neurons that project to prefrontal cortex (Parent, 1996). Previous functional neuroimaging studies have indicated cerebellar involvement in information processing; the cerebellum has been suggested to aid flexible cognitive operations that may be of particular importance in DIV by modeling prefrontal information processing (Leiner et al, 1993;Cabeza and Nyberg, 2000;Ramnani, 2006). Furthermore, analogous to motor functions, a cortico-cerebellar-thalamic-cortical circuit has been suggested to facilitate a fluid coordination of cognitive activities by fine-tuning the timing and sequencing of the information flow (Andreasen et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Divided versus selective attention: Evidence for common processing mechanisms

et al. 2008

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The current study revisited the question of whether there are brain mechanisms specific to divided attention that differ from those used in selective attention. Increased neuronal activity required to simultaneously process two stimulus dimensions as compared with each separate dimension has often been observed, but rarely has activity induced by a divided attention condition exceeded the sum of activity induced by the component tasks. Healthy participants performed a selective-divided attention paradigm while undergoing functional Magnetic Resonance Imaging (fMRI). The task required participants to make a same-different judgment about either one of two simultaneously presented stimulus dimensions, or about both dimensions. Performance accuracy was equated between tasks by dynamically adjusting the stimulus display time. Blood Oxygenation Level Dependent (BOLD) signal differences between tasks were identified by whole-brain voxel-wise comparisons and by region-specific analyses of all areas modulated by the divided attention task (DIV). No region displayed greater activation or deactivation by DIV than the sum of signal change by the two selective attention tasks. Instead, regional activity followed the tasks' processing demands as reflected by reaction time. Only a left cerebellar region displayed a correlation between participants' BOLD signal intensity and reaction time that was selective for DIV. The correlation was positive, reflecting slower responding with greater activation. Overall, the findings do not support the existence of functional brain activity specific to DIV. Increased activity appears to reflect additional processing demands by introducing a secondary task, but those demands do not appear to qualitatively differ from processes of selective attention. SectionCognitive and Behavioral Neuroscience

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Cognitive and language functions of the human cerebellum

Cited by 663 publications

References 26 publications

The expression pattern of nuclear receptors during cerebellar development

The expression pattern of nuclear receptors during cerebellar development

The evolution of the cortico-cerebellar complex in primates: anatomical connections predict patterns of correlated evolution

Divided versus selective attention: Evidence for common processing mechanisms

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