Cognitive and neuropsychiatric disease manifestations in MS

Feinstein, Anthony; DeLuca, John; Baune, Bernhard T.; Filippi, Massimo; Lassman, Hans

doi:10.1016/j.msard.2012.08.001

Cited by 49 publications

(35 citation statements)

References 98 publications

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“…The course of MS progression is largely unpredictable, thereby posing major challenges to patients trying to cope with the disease 1. Moreover, MS frequently has a negative impact on family and social life, and patients with MS have a high risk of developing depression, anxiety and other psychological disorders 2. Importantly, social support and good interpersonal relationships have been shown to reduce the risk of depression and increase quality of life in MS 3…”

Section: Introductionmentioning

confidence: 99%

Impaired social cognition in multiple sclerosis

Pöttgen

Dziobek

Reh

et al. 2013

Journal of Neurology, Neurosurgery & Psychiatry

107

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Section: Introductionmentioning

confidence: 99%

Impaired social cognition in multiple sclerosis

Pöttgen

Dziobek

Reh

et al. 2013

Journal of Neurology, Neurosurgery & Psychiatry

107

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show abstract

“…The most frequently used ones are the multifaceted empathy test (MET) [37], the visual recognition test, the Florida Affect Battery (FAB) and Ekman and Friesen's black and white stimulus set. The results of these tests minimize subjectivity in the patient's self-assessment [38].…”

Section: Clinical Assessment Of Social Cognition In Patients With Msmentioning

confidence: 99%

Social Cognition Impairments in Patients with Multiple Sclerosis and Comparison with Imaging Studies, Disease Duration and Grade of Disability

Ignatova¹,

Todorova²,

Surchev³

2016

Trending Topics in Multiple Sclerosis

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Cognitive impairments in multiple sclerosis (MS) are heterogeneous and their rate varies between 43% and 70%. A less studied aspect of cognition is social cognition, which is not a uniform theoretical construct. It includes emotion perception, prosody, empathy, theory of mind (ToM) and assessment of mood. In addition to progressive physical disability, social cognitive impairments are a reason for job loss in 24-80% of patients with MS, increased divorce rate, dissolution of partnerships and social communication difficulties.Social cognitive impairments are the result of disruptions in the mentalization network at the neuroanatomical, neurochemical and/or genetic level, which can lead to malfunctions in the dopaminergic-serotoninergic system and to compromising the development of neuroanatomical targets within the network. The wide dissemination of demyelinating lesions and cortical thinning typical of patients with MS often lead to anatomic and functional disorders of the above-mentioned specific brain structures. A correlation has been established among specific cortical areas involved in emotion identification from facial expression (right and left fusiform face area, frontal eye), emotion processing (right entorhinal cortex) and socially relevant information (left temporal pole). The most active brain region involved in social cognitive processing is the medal frontal cortex (MFC), which is described as the brain's social cognitive center. During performance of various sociocognitive tasks for mental state attribution, common areas of increased activation in the medial prefrontal gyrus and the temporoparietal junctions are registered bilaterally, while the area of the medial prefrontal cortex (the paracingulate cortex) is the only region uniquely activated by the performance of ToM.Most MRI studies of patients with MS found a correlation between the cognitive and/or affective disorders, on the one hand, and lesion localization, total lesion load, or cerebral atrophy, on the other. A significant correlation was also reported between © 2016 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.abnormal activities in specific cortical zones on fMRI, on the one hand, and clinical manifestation, conventional MRI findings and behavioral changes, on the other. Altered patterns of brain activity were found in all clinical phenotypes of MS, including when cognitive abilities were intact and/or restored, social cognitive dysfunction in MS actually affects all stages of the disease and all types of clinical course. The cortical plastic changes are a dynamic phenomenon that can be modulated by external factors. This phenomenon would facilitate the mapping of individual strategies for adequate treatment and rehabilitation of each patient.

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“…The occurrence of PBA has been reported in a multitude of neurologic illnesses including, but not limited to, ALS, [15][16][17][18][19] PD and other movement disorders, 13,[20][21][22] MS, [23][24][25][26][27][28][29][30][31][32][33][34][35][36][37] stroke, [38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54] various types of dementia and other neurodegenerative disorders, 55-62 traumatic brain injury (TBI), 63-66 central nervous system tumors, [67][68][69][70][71][72][73][74]...…”

Section: Epidemiologymentioning

confidence: 99%

The epidemiology and pathophysiology of pseudobulbar affect and its association with neurodegeneration

King¹,

Reiss²

2013

DNND

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Pseudobulbar affect is a disorder resulting from neurologic damage manifesting as sudden, stereotyped affective outbursts that are not reflective of internal emotion. A literature review was completed to examine the current understanding of the epidemiology, characterization, diagnosis, pathophysiology, and treatment of pseudobulbar affect. This review revealed that it is common in neurodegenerative disorders but is poorly recognized, placing significant impacts on patients and their families. The disorder appears to result from a disruption of the cortico-limbicsubcortical-thalamic-pontocerebellar network involved in emotional expression and regulation with resulting disruptions of neurotransmitter systems. Effective treatment is available with agents such as selective serotonin reuptake inhibitors and dextromethorphan combined with quinidine, but further well-designed comparative studies are needed. Advances in technology such as neuroimaging may enhance knowledge about the pathophysiology of this disorder, and help guide future interventions.

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Cognitive and neuropsychiatric disease manifestations in MS

Cited by 49 publications

References 98 publications

Impaired social cognition in multiple sclerosis

Impaired social cognition in multiple sclerosis

Social Cognition Impairments in Patients with Multiple Sclerosis and Comparison with Imaging Studies, Disease Duration and Grade of Disability

The epidemiology and pathophysiology of pseudobulbar affect and its association with neurodegeneration

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