Impaired social cognition in multiple sclerosis

Pöttgen, Jana; Dziobek, Isabel; Reh, Susan; Heesen, Christoph; Gold, Stefan M.

doi:10.1136/jnnp-2012-304157

Cited by 107 publications

(93 citation statements)

References 48 publications

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“…McGuire et al, 2009 Reniers et al, 2011). Third, the current study did not directly assess ToM deficits in MS population, but we do note the substantial literature demonstrating these deficits in MS patients (Banati et al, 2010;Charvet et al, 2014;Henry et al, 2009Henry et al, , 2011Kraemer et al, 2013;Ouellet et al, 2010;Pöttgen et al, 2013;Roca et al, 2014). Fourth, this was an exploratory study that found EOT to play an important role in moral cognition, and thus future studies need to further explore the exact mechanism by which this dimension of alexithymia interacts with incidental affect and how this interaction has downstream consequences for moral judgments.…”

Section: Methodologicalmentioning

confidence: 98%

“…In particular, MS patients perform poorly in extracting information about intentionality, representing first-and second-order false beliefs, and detecting social faux pas in verbal/nonverbal ToM assessment tasks (Banati et al, 2010;Charvet et al, 2014;Henry et al, 2011;Pöttgen et al, 2013;Roca et al, 2014). These deficits remain even after controlling for the co-occurring neuropsychological impairments, such as executive function deficits (Charvet et al, 2014;Pöttgen et al, 2013). Importantly, ToM deficits appear from the very early stage of the disease in young adults (Kraemer et al, 2013) and are found even in pediatric-onset MS patients (Charvet et al, 2014).…”

Section: Ms and Deficits In Social Cognitionmentioning

confidence: 99%

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Elevated moral condemnation of third-party violations in multiple sclerosis patients

Patil

Young

Sinay

et al. 2016

Social Neuroscience

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Section: Methodologicalmentioning

confidence: 98%

Section: Ms and Deficits In Social Cognitionmentioning

confidence: 99%

Elevated moral condemnation of third-party violations in multiple sclerosis patients

Patil

Young

Sinay

et al. 2016

Social Neuroscience

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“…In the same year, Ouellet arrived at the conclusion that patients with MS suffering from cognitive deficits tend not to recognize the mental state of others unlike MS patients with preserved cognition (15 cognitively intact and 26 cognitively impaired patients) [49], while Henry (64 patients with relapsing-remitting MS (RRMS), 30 controls) [78] and Pöttgen (45 patients with MS, 45 healthy controls) [21] found that ToM deficits in MS appear independently of the well-known cognitive deficits. Emotion recognition impairments were more pronounced in patients with MS than impairments in thought and intention recognition [21,79].…”

Section: Social Cognition Impairments In Patients With Multiple Sclermentioning

confidence: 99%

“…ToM is viewed as a specific capacity of the mind to understand ourselves and others in terms of mental states. It is based on "reading the thoughts and emotions" of others through analyzing their facial expressions and other behavioral signs [21,22]. ToM provides the opportunity for establishing a connection between internal conditions manifested through expressions, gestures, signals and internal states of mind.…”

Section: What Is Social Cognition?mentioning

confidence: 99%

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Social Cognition Impairments in Patients with Multiple Sclerosis and Comparison with Imaging Studies, Disease Duration and Grade of Disability

Ignatova¹,

Todorova²,

Surchev³

2016

Trending Topics in Multiple Sclerosis

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Cognitive impairments in multiple sclerosis (MS) are heterogeneous and their rate varies between 43% and 70%. A less studied aspect of cognition is social cognition, which is not a uniform theoretical construct. It includes emotion perception, prosody, empathy, theory of mind (ToM) and assessment of mood. In addition to progressive physical disability, social cognitive impairments are a reason for job loss in 24-80% of patients with MS, increased divorce rate, dissolution of partnerships and social communication difficulties.Social cognitive impairments are the result of disruptions in the mentalization network at the neuroanatomical, neurochemical and/or genetic level, which can lead to malfunctions in the dopaminergic-serotoninergic system and to compromising the development of neuroanatomical targets within the network. The wide dissemination of demyelinating lesions and cortical thinning typical of patients with MS often lead to anatomic and functional disorders of the above-mentioned specific brain structures. A correlation has been established among specific cortical areas involved in emotion identification from facial expression (right and left fusiform face area, frontal eye), emotion processing (right entorhinal cortex) and socially relevant information (left temporal pole). The most active brain region involved in social cognitive processing is the medal frontal cortex (MFC), which is described as the brain's social cognitive center. During performance of various sociocognitive tasks for mental state attribution, common areas of increased activation in the medial prefrontal gyrus and the temporoparietal junctions are registered bilaterally, while the area of the medial prefrontal cortex (the paracingulate cortex) is the only region uniquely activated by the performance of ToM.Most MRI studies of patients with MS found a correlation between the cognitive and/or affective disorders, on the one hand, and lesion localization, total lesion load, or cerebral atrophy, on the other. A significant correlation was also reported between © 2016 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.abnormal activities in specific cortical zones on fMRI, on the one hand, and clinical manifestation, conventional MRI findings and behavioral changes, on the other. Altered patterns of brain activity were found in all clinical phenotypes of MS, including when cognitive abilities were intact and/or restored, social cognitive dysfunction in MS actually affects all stages of the disease and all types of clinical course. The cortical plastic changes are a dynamic phenomenon that can be modulated by external factors. This phenomenon would facilitate the mapping of individual strategies for adequate treatment and rehabilitation of each patient.

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Mentalizing self mind but not others: Self‐reported mentalization difficulties in multiple sclerosis

Kuzu Kumcu,

Törenli Kaya,

Hoşgören Alıcı

2024

Brain and Behavior

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BackgroundMentalization can be defined as a mental process by which an individual directly or indirectly perceives and interprets one's own and others' behavior, emotions, beliefs, and needs based on designed mental states. Mentalization problems may be linked to remove associative white matter fiber disconnection. Multiple sclerosis (MS) is one of the diseases with white matter lesions. By comparing MS patients with healthy controls, it was aimed to assess whether MS patients' mentalization skills are affected.MethodThis study involved 243 participants (170 healthy controls and 73 patients with MS). All the participants completed a sociodemographic questionnaire and the Mentalization Scale (MentS).ResultsWhile it was discovered that MentS scores for the dimension of others‐based mentalization (MentS‐O) were statistically lower in MS group, there was no statistically significant difference between the groups in terms of the dimensions of motivation to mentalize (MentS‐M) and self‐based mentalization (MentS‐S) scores.ConclusionWe may conclude that MS patients have trouble comprehending other people's thoughts. This effect can be one of the causes of MS patients' issues with social cognition.

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Impaired social cognition in multiple sclerosis

Cited by 107 publications

References 48 publications

Elevated moral condemnation of third-party violations in multiple sclerosis patients

Elevated moral condemnation of third-party violations in multiple sclerosis patients

Social Cognition Impairments in Patients with Multiple Sclerosis and Comparison with Imaging Studies, Disease Duration and Grade of Disability

Mentalizing self mind but not others: Self‐reported mentalization difficulties in multiple sclerosis

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