Cognitive Benefit of a Multidomain Intervention for Older Adults at Risk of Cognitive Decline: A Cluster-Randomized Controlled Trial

Liu, Xiaomei; Ma, Zhuoya; Zhu, Xinyi; Zheng, Zhili; Li, Jing; Fu, Jiangning; Shao, Qi; Han, Xijiang; Wang, Xiaoning; Wang, Zhihui; Yin, Zhaoxue; Qiu, Chengxuan; Li, Juan

doi:10.1016/j.jagp.2022.10.006

Cited by 6 publications

(3 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We included 25 RCTs, conducted in six countries (China= 17; Brazil= 3; India= 1; Pakistan= 1; Thailand=1; Turkey= 1). 24 studies included people with inclusion criteria equating to Mild Cognitive Impairment, and one participants with SCC (Liu et al, 2023). Intervention durations ranged from one to six months, and all primary outcomes were collected immediately after the intervention periods.…”

Section: Resultsmentioning

confidence: 99%

“…Kwan et al (2020) tested 12 weeks of an mhealth-delivered goal-setting and behavioural change intervention. Liu et al (2023) tested a 9-month mindfulness meditation, cognitive training, physical exercise, and nutrition counselling group intervention. This last component was provided by a physician, while the group sessions were supervised by trained research assistants.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Lifestyle interventions for dementia prevention in Low- and Middle-Income Countries: A systematic review

Espinoza Jeraldo,

Zabihi,

Miranda-Castillo

et al. 2024

Preprint

View full text Add to dashboard Cite

By 2050, two-thirds of people with dementia will live in Low- and Middle-Income Countries (LMICs). Efforts to adapt and test multi-modal prevention interventions focusing on lifestyle changes for people at risk of dementia are being developed predominantly in higher income countries, for people with and without cognitive symptoms. However, there is evidence that needs may differ between these groups. We systematically reviewed Randomized Controlled Trials (RCTs) evaluating non-pharmacological interventions in individuals with Mild Cognitive Impairment (MCI) and Subjective Cognitive Decline (SCC) in LMICs. We analysed study quality using the Mixed Methods Assessment Tool (MMAT), meta-analysed and synthesized evidence. We included 25 RCTs, from six countries (most in China, n=17), involving 1304 participants. Across the 15 studies for which there was sufficient data to meta-analyse, we found significant positive effects on cognitive outcomes favouring interventions [1.49 (standardised mean difference, 95% Confidence Interval= 1.06-1.93)]. There was significant publication bias. Using an a priori standard framework, we classified interventions into exercise, multidomain, and arts/creative expression. Group exercise [1.67, 1.24-2.11, n=8]. and multidomain [1.22, 0.22-2.21, n=5] had replicated evidence of effectiveness. There was insufficient data to meta-analyse the creative arts category. We identified one high quality, multi-modal intervention, which combined Chinese mind-body exercises and health education, reporting a positive outcome. The first robust dementia prevention trials are underway in LMICs, evaluating effectiveness of models developed in higher income countries. We propose greater consideration and investment in development of interventions that account for specific LMIC contexts from the outset, so they are acceptable and used by local services.HighlightsThere was evidence that group exercise and multimodal interventions were effective for people with memory concerns in LMICs.We identified publication bias in meta-analyses; the open science agenda is critical to improving care in LMICs and reducing global inequalities.Most included studies were conducted in China, reflecting a need for high-quality evidence from underrepresented regions, including Africa and Latin America.We propose greater investment in developing interventions that account for specific LMIC contexts from the outset, so they are acceptable and used by local services.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Lifestyle interventions for dementia prevention in Low- and Middle-Income Countries: A systematic review

Espinoza Jeraldo,

Zabihi,

Miranda-Castillo

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…For example, the FINGER trial demonstrated that a 2-year multidomain intervention of diet, physical exercise, and cognitive training improved cognitive performance in at-risk elderly people [10]. A recent RCT study also showed that immediately after a 9-month multidomain intervention of meditation, physical exercise, cognitive training, and nutrition counseling, cognitive performance was significantly enhanced in community-dwelling older adults who were at risk of cognitive decline [11]. Several studies employing comparable multidomain intervention approaches but over a shorter training duration (e.g., 2 to 6 months) have also yielded promising outcomes in older adults with SCD [9,12].…”

Section: Introductionmentioning

confidence: 99%

Effects of 6-Month Combined Physical Exercise and Cognitive Training on Neuropsychological and Neurophysiological Function in Older Adults with Subjective Cognitive Decline: A Randomized Controlled Trial

Cheng,

Hsieh,

Chang

et al. 2024

JAD

View full text Add to dashboard Cite

Background: Multidomain intervention may delay or ameliorate cognitive decline in older adults at risk of Alzheimer’s disease, particularly in the memory and inhibitory functions. However, no study systematically investigates the changes of brain function in cognitively-normal elderly with subjective cognitive decline (SCD) when they receive multidomain intervention. Objective: We aimed to examine whether a multidomain intervention could improve neuropsychological function and neurophysiological activities related to memory and inhibitory function in SCD subjects. Methods: Eight clusters with a total of 50 community-dwelling SCD older adults were single-blind, randomized into intervention group, which received physical and cognitive training, or control group, which received treatment as usual. For the neuropsychological function, a composite Z score from six cognitive tests was calculated and compared between two groups. For the neurophysiological activities, event-related potentials (ERPs) of memory function, including mismatch negativity (MMN) and memory-P3, as well as ERPs of inhibitory function, including sensory gating (SG) and inhibition-P3, were measured. Assessments were performed at baseline (T1), end of the intervention (T2), and 6 months after T2 (T3). Results: For the neuropsychological function, the effect was not observed after the intervention. For the neurophysiological activities, improved MMN responses of ΔT2–T1 were observed in the intervention group versus the control group. The multidomain intervention produced a sustained effect on memory-P3 latencies of ΔT3–T1. However, there were no significant differences in changes of SG and inhibition-P3 between intervention and control groups. Conclusions: While not impactful on neuropsychological function, multidomain intervention enhances specific neurophysiological activities associated with memory function.

show abstract

Cognitive and Hippocampal Changes in Older Adults With Subjective Cognitive Decline After Acupuncture Intervention

Wang,

Zhou,

Yan

et al. 2024

The American Journal of Geriatric Psychiatry

View full text Add to dashboard Cite

Cognitive Benefit of a Multidomain Intervention for Older Adults at Risk of Cognitive Decline: A Cluster-Randomized Controlled Trial

Cited by 6 publications

References 34 publications

Lifestyle interventions for dementia prevention in Low- and Middle-Income Countries: A systematic review

Lifestyle interventions for dementia prevention in Low- and Middle-Income Countries: A systematic review

Effects of 6-Month Combined Physical Exercise and Cognitive Training on Neuropsychological and Neurophysiological Function in Older Adults with Subjective Cognitive Decline: A Randomized Controlled Trial

Cognitive and Hippocampal Changes in Older Adults With Subjective Cognitive Decline After Acupuncture Intervention

Contact Info

Product

Resources

About