Cognitive deficit is related to immune-cell beta-NGF in multiple sclerosis patients

Kalinowska-Łyszczarz, Alicja; Pawlak, Mikołaj A.; Michalak, Sławomir; Losy, Jacek

doi:10.1016/j.jns.2012.07.044

Cited by 12 publications

(12 citation statements)

References 33 publications

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“…Our group observed that lower immune-cell NT-3 is associated with more advanced brain atrophy in RRMS patients [55]. We have also found that in RRMS patients cognitive deficit is related with immune-cell beta-NGF [56]. Similarily, Patanella et al .…”

Section: Neurotrophins and Ms Pathologysupporting

confidence: 60%

The Role of Neurotrophins in Multiple Sclerosis—Pathological and Clinical Implications

Kalinowska-Łyszczarz

Losy

2012

IJMS

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Multiple sclerosis (MS) is a chronic inflammatory demyelinating and neurodegenerative disease of the central nervous system (CNS) with unknown etiology. It was recently suggested that autoimmunity, which had long been considered to be destructive in MS, might also play a protective role in the CNS of MS patients. Neurotrophins are polypeptides belonging to the neurotrophic factor family. While neurotrophins mediate cell survival and proliferation in the nervous system, they are also expressed within peripheral blood mononuclear cells fraction (PBMCs) of immunological system. In MS additional neurotrophic support from PBMCs might compensate relative neurotrophins deficiency in the damaged CNS tissue that needs to be repaired. Failure to produce the adequate neurotrophins concentrations might result in decreased protection of the CNS, consequently leading to increased atrophy, which is the main determinant of MS patients’ end-point disability. There are several lines of evidence, both from clinical research and animal models, suggesting that neurotrophins play a pivotal role in neuroprotective and neuroregenerative processes that are often defective in the course of MS. It seems that neuroprotective strategies might be used as potentially valuable add-on therapies, alongside traditional immunomodulatory treatment in multiple sclerosis.

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Section: Neurotrophins and Ms Pathologysupporting

confidence: 60%

The Role of Neurotrophins in Multiple Sclerosis—Pathological and Clinical Implications

Kalinowska-Łyszczarz

Losy

2012

IJMS

Self Cite

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“…Since that time, we have identified more than 150 published articles, theses, reports, conference presentations, and similar publications that have used or cited PEBL. These cover disciplines including Artificial Intelligence (Mueller, 2010), cognitive psychology (Worthy, Hawthorne, & Otto, 2013), neurology (Clark & Kar, 2011; Kalinowska-Łyszczarz, Pawlak, Michalak, & Losy, 2012), clinical psychology (Gullo & Stieger, 2011), cognitive neuroscience (Danckert, Stöttinger, Quehl, & Anderson, 2012), behavioral endocrinology (Premkumar, Sable, Dhanwal, & Dewan, 2012), medical education (Aggarwal, Mishra, Crochet, Sirimanna, & Darzi, 2011), neuropharmacology (Lyvers & Tobias-Webb, 2010), physiology (Piquet, Balestra, Sava, & Schoenen, 2011), developmental neuroscience (Piper, 2011), genetics (Ness et al 2011), computer science (Cinaz, Vogt, Arnrich, & Tröster, 2012), and human factors (Lipnicki et al, 2009; Qiu & Helbig, 2012). …”

Section: The Pebl Test Batterymentioning

confidence: 99%

The Psychology Experiment Building Language (PEBL) and PEBL Test Battery

Mueller

Piper

2014

Journal of Neuroscience Methods

845

648

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Background We briefly describe the Psychology Experiment Building Language (PEBL), an open source software system for designing and running psychological experiments. New Method We describe the PEBL test battery, a set of approximately 70 behavioral tests which can be freely used, shared, and modified. Included is a comprehensive set of past research upon which tests in the battery are based. Results We report the results of benchmark tests that establish the timing precision of PEBL. Comparison with Existing Method We consider alternatives to the PEBL system and battery tests. Conclusions We conclude with a discussion of the ethical factors involved in the open source testing movement.

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“…27 Level of education was defined as number of education years and level (level 1: primary education, eight years; level 2: basic vocational education, total of 12 years; level 3: upper secondary education, total 12 years; level 4: university education, total of 17 years). As in a previously published study, 28 we defined results obtained in each neuropsychological test as deficient when they were worse than the median for the given test. Therefore, the cognitive composite score had a range from 0 (all test results above median) to 6 (all test results below median).…”

Section: Methodsmentioning

confidence: 99%

Subcortical gray matter atrophy is associated with cognitive deficit in multiple sclerosis but not in systemic lupus erythematosus patients

Kalinowska-Łyszczarz

Pawlak

Pietrzak

et al. 2017

Lupus

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Cognitive impairment is a significant clinical problem both in multiple sclerosis (MS) and systemic lupus erythematosus (SLE) patients. In MS cognitive dysfunction has been associated with brain atrophy and total demyelinating lesion volume. In SLE cognitive impairment is much less understood, and its link to structural brain damage remains to be established. The aim of this study was to identify the relationship between subcortical gray matter volume and cognitive impairment in MS and SLE. We recruited 37 MS and 38 SLE patients matched by age, disease duration and educational level. Patients underwent magnetic resonance imaging (MRI) and a battery of psychometric tests. Severity of cognitive impairment was similar in both cohorts despite larger white matter lesion load in MS patients. Psychometric scores were associated with global and subcortical gray matter atrophy measures and lesion load in MS, but not in SLE. In SLE, the lack of a relationship between cognitive impairment and structural damage, defined either as atrophy or white matter lesions, indicates a different causal mechanism of cognitive deficit.

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Cognitive deficit is related to immune-cell beta-NGF in multiple sclerosis patients

Cited by 12 publications

References 33 publications

The Role of Neurotrophins in Multiple Sclerosis—Pathological and Clinical Implications

The Role of Neurotrophins in Multiple Sclerosis—Pathological and Clinical Implications

The Psychology Experiment Building Language (PEBL) and PEBL Test Battery

Subcortical gray matter atrophy is associated with cognitive deficit in multiple sclerosis but not in systemic lupus erythematosus patients

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