Cognitive deficits in schizophrenia: Prediction of symptom change for participants in rehabilitation

Lysaker, Paul H.; Bell, M.D.; Bioty, Stephen M.

doi:10.1016/0920-9964(95)95672-v

Cited by 16 publications

(28 citation statements)

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“…If such interference is as significant as suggested here, then assisting impaired consumers to enrich and broaden narrative through psychotherapy may represent a needed intervention. The most neurocognitively impaired consumers have been shown to be at greater risk of not benefiting clinically from vocational rehabilitation (Lysaker, Bell, and Bioty 1995). Perhaps helping these consumers develop enhanced ways of understanding the role of work in their life story might increase the likelihood of positive outcomes.…”

Section: Discussionmentioning

confidence: 97%

Psychotherapy as an Element in Supported Employment for Persons with Severe and Persistent Mental Illness

Lysaker

1999

Psychiatry

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Recent literature has urged that vocational and clinical services for persons with severe and persistent mental illness should be integrated. Unclear in this model is what role psychotherapy could play. In particular, it is unknown whether psychotherapy can make a unique contribution and whether there are issues it might systematically address in the context of vocational rehabilitation. To examine these questions we report on the psychotherapy of six consumers enrolled in supported employment, a prominent form of vocational rehabilitation. Using these cases as illustrations, we suggest that in an integrative team approach, psychotherapy can facilitate vocational rehabilitation by helping consumers reconstruct aspects of personal narratives related to disability and work and by processing painful affects evoked by work. We report how within a reflective and nonhierarchical relationship consumers were allowed to reframe old ideas, question inconsistencies, and keep track of the structure and content of revised narrative until fully integrated into memory. Despite a wide range of severe impairments, this process enabled consumers to incorporate work into a now more complete and coherent life narrative. Implications for practice and research are discussed.

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Section: Discussionmentioning

confidence: 97%

Psychotherapy as an Element in Supported Employment for Persons with Severe and Persistent Mental Illness

Lysaker

1999

Psychiatry

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“…Because improvement in formal thought disorders and language disturbances is crucial for social interaction and therefore for social integration of patients with schizophrenia, the results may be of particular interest. 88 Lysaker et al 89 , eg, have shown that concretism and cognition impairments measured by the Gorham Proverb Test 71 and/or the Wisconsin Card Sorting Test 90 , respectively, are associated with a reduction in the clinical effects of rehabilitation. Further studies provide empirical evidence for the association between concretism measured with the Gorham Proverb Test and difficulties in social integration.…”

Section: Discussionmentioning

confidence: 99%

Estrogen and Comprehension of Metaphoric Speech in Women Suffering From Schizophrenia: Results of a Double-Blind, Placebo-Controlled Trial

Bergemann¹,

Parzer²,

Auler³

et al. 2008

Schizophrenia Research

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“…Some studies suggested that neurocognitive tests could be used to predict prognosis or the future effect of treatment in patients with schizophrenia 16-19. Robinson et al18 concluded that the treatment response of schizophrenia patients could be predicted by using attention and motor vulnerability.…”

Section: Introductionmentioning

confidence: 99%

Cognitive Factors for Predicting Treatment Response in Schizophrenic Patients: One-Year Follow-Up Study

Kim

Lee

Hur

et al. 2008

Psychiatry Investig

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ObjectiveThis study was conducted to investigate the cognitive factors that can longitudinally predict the response to treatment in patients with schizophrenia.MethodsThe subjects were 49 patients with schizophrenia who were newly hospitalized in an acute psychiatry ward and had not been treated with medication for at least 8 weeks prior to the study. The symptoms and cognitive functions of the patients were evaluated at baseline before treatment (T0), at eight weeks after treatment (T1), and one year after treatment (T2). Clinical symptoms were assessed using the PANSS, and cognitive functions were estimated using the Vigilance Test, Cognitrone Test, Wisconsin Card Sorting Test (WCST), and the Korean version of the Memory Assessment Scales (K-MAS).ResultsThe patient group showed marked impairments in cognitive function when compared to the normal group, but the patients' clinical symptoms and cognitive functions improved after drug treatment. The patients also showed consistent improvement in verbal and nonverbal memory function as time progressed. Furthermore, there was a significant correlation between clinical symptoms and cognitive functions in the patient group. The cognitive variables that best predicted treatment response and prognosis were total errors on the WCST and immediate list recall component of the K-MAS. It was also shown that the number of total errors on the WCST was a better cognitive predictor than the number of errors in immediate recall.ConclusionThe results of the present study show that the neurocognitive functions of patients with schizophrenia can be stabilized with treatment intervention, that treatment response is related to improvement in cognitive function, and that cognitive domains, especially executive function, can predict treatment response and prognosis in patients with schizophrenia.

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Cognitive deficits in schizophrenia: Prediction of symptom change for participants in rehabilitation

Cited by 16 publications

References 0 publications

Psychotherapy as an Element in Supported Employment for Persons with Severe and Persistent Mental Illness

Psychotherapy as an Element in Supported Employment for Persons with Severe and Persistent Mental Illness

Estrogen and Comprehension of Metaphoric Speech in Women Suffering From Schizophrenia: Results of a Double-Blind, Placebo-Controlled Trial

Cognitive Factors for Predicting Treatment Response in Schizophrenic Patients: One-Year Follow-Up Study

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