Cognitive deficits in the rat chronic mild stress model for depression: Relation to anhedonic-like responses

Henningsen, Kim; Andreasen, Jesper T.; Bouzinova, Elena V.; Jayatissa, Magdalena Niepsuj; Jensen, Morten Skovgaard; Redrobe, John P.; Wiborg, Ove

doi:10.1016/j.bbr.2008.10.039

Cited by 116 publications

(100 citation statements)

References 49 publications

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“…This is a standard definition of anhedonia-like behavior in CMS rat studies (3, 4, 6 -8, 12-14, 33, 34, 39 -42, 55, 57). The anhedonic-like behavior correlates strongly with other depression markers (3,12,33).…”

Section: Methodsmentioning

confidence: 82%

“…Food and water were available ad libitum, except when food and/or water deprivation was applied as a stressor. The standard 12:12-h light-dark cycle (light phase 0600 -1800) was only changed in the course of the stress exposure (14,33,39). The weight of a subgroup of rats was obtained regularly throughout the study.…”

Section: Methodsmentioning

confidence: 99%

“…The baseline sucrose consumption was measured during 3 wk. Then rats were divided into two groups, where one group was exposed to CMS for 8 wk and the other remained unchallenged (3,7,8,13,14,33,34,36,41,42,57 SCT. SCT measures the sucrose intake of individual rats during 1-h exposure to a bottle with 1.5% sucrose solution.…”

Section: Methodsmentioning

confidence: 99%

“…The applied CMS procedure was described in detail previously (33,39,57) and was repeated in accordance with the previous studies (3, 4, 6 -8, 12-14, 34, 40 -42, 55). Briefly, the chronic mild stress protocol with a 14-day cycle consisted of one period of intermittent illumination, stroboscopic light, grouping, food or water deprivation, two periods of soiled cage, and no stress, and three periods of 45°box tilting.…”

Section: Methodsmentioning

confidence: 99%

“…The CMS paradigm originally involved a large group of rats whose hedonic state was analyzed after the first 4 wk of stress (3,14,33,57). Rats exposed to CMS showed differential stress susceptibility with ϳ50% being anhedonic, while others were either resilient (no change in sucrose intake) or reduced their sucrose intake Ͻ30% (61,70,71).…”

Section: Methodsmentioning

confidence: 99%

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Chronic selective serotonin reuptake inhibition modulates endothelial dysfunction and oxidative state in rat chronic mild stress model of depression

Matchkov

Кравцова

Wiborg

et al. 2015

American Journal of Physiology-Regulatory, Integrative and Comp

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Matchkov VV, Kravtsova VV, Wiborg O, Aalkjaer C, Bouzinova EV. Chronic selective serotonin reuptake inhibition modulates endothelial dysfunction and oxidative state in rat chronic mild stress model of depression. Am J Physiol Regul Integr Comp Physiol 309: R814 -R823, 2015. First published August 12, 2015 doi:10.1152/ajpregu.00337.2014.-Major depression is known to be associated with cardiovascular abnormalities, and oxidative stress has been suggested to play a role. We tested the hypothesis that antidepressant treatment reduces oxidative stress and endothelial dysfunctions in the chronic mild stress (CMS) model of depression in rats. Rats with Ͼ30% reduction in sucrose intake after 4 wk of CMS were defined in the study as CMS-susceptible and compared with unstressed controls. Sixteen CMS-susceptible and eight unstressed rats were treated during weeks 5 to 8 of the CMS protocol with escitalopram. Escitalopram-treated rats with Ͼ20% recovery in the sucrose consumption during the last 2 wk of treatment were defined as escitalopram responders. Rats that did not reach these criteria were defined as escitalopram nonresponders. In the open field test, escitalopram responders demonstrated anxiolytic effect of treatment. In mesenteric small arteries, escitalopram affected neither NO nor cyclooxygenase-1 (COX-1)-mediated vasodilation. Escitalopram potentiated endothelium-dependent hyperpolarization-like response, which was suppressed in the vehicle-treated CMS-susceptible rats and reduced COX-2-dependent relaxation, which was elevated in the vehicle-treated CMS-susceptible rats. Escitalopram did not affect blood pressure and heart rate, which were elevated in the vehicle-treated CMS-susceptible rats. Oxidative stress markers were changed in association with CMS in liver, heart, and brain. Escitalopram normalized oxidative stress markers in the majority of tissues. This study demonstrates that the antidepressant effect of escitalopram is associated with partial improvement of endothelial function in small arteries affecting COX-2 and endothelium-dependent hyperpolarization-like pathways.depression; chronic mild stress; escitalopram; endothelium; nitric oxide synthase; cyclooxygenase; endothelium-derived hyperpolarization; oxidative stress; glutathione; malondialdehyde CARDIOVASCULAR DISEASES AND major depressive disorder are the two most prevalent health problems in high-income countries (31). Their comorbidity is well recognized, but the mechanisms and critical factors underlying this comorbidity are unknown. Interactions between several factors common for both disorders are complex (17; 43). Thus, a dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis and activation of the renin-angiotensin-aldosterone system lead to changes associated with both depression and cardiovascular abnormalities.Also dysfunction of the autonomic nervous system (sympathetic/parasympathetic) is known to be involved, as well as an activation of proinflammatory cytokines (46). Importantly, these factors can induce both depression and ch...

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Section: Methodsmentioning

confidence: 82%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Chronic selective serotonin reuptake inhibition modulates endothelial dysfunction and oxidative state in rat chronic mild stress model of depression

Matchkov

Кравцова

Wiborg

et al. 2015

American Journal of Physiology-Regulatory, Integrative and Comp

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Adolescent intermittent ethanol exposure does not alter responsiveness to ifenprodil or expression of vesicular GABA and glutamate transporters

Dannenhoffer

Werner

Spear

2021

Developmental Psychobiology

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Adolescent intermittent ethanol (AIE) exposure in the rat results in a retention of adolescent‐like responsiveness to ethanol into adulthood characterized by enhanced sensitivity to socially facilitating and decreased sensitivity to socially suppressing and aversive effects. Similar pattern of responsiveness to social and aversive effects of the selective glutamate NMDA NR2B receptor antagonist ifenprodil is evident in adolescent rats, suggesting that AIE would also retain this pattern of ifenprodil sensitivity into adulthood. Social (Experiment 1) and aversive (measured via conditioned taste aversion; Experiment 2) effects of ifenprodil were assessed in adult male and female rats following AIE exposure. Sensitivity to the social and aversive effects of ifenprodil was not affected by AIE exposure. Experiment 3 assessed protein expression of vesicular transporters of GABA (vGAT) and glutamate (vGlut2) within the prelimbic cortex and nucleus accumbens in adolescents versus adults and in AIE adults versus controls. vGlut2 expression was higher in adolescents relative to adults within the PrL, but lower in the NAc. AIE adults did not retain these adolescent‐typical ratios. These findings suggest that AIE is not associated with the retention of adolescent‐typical sensitivity to NR2B receptor antagonism, along with no AIE‐induced shift in vGlut2 to vGAT ratios.

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Hippocampal GABAergic dysfunction in a rat chronic mild stress model of depression

et al. 2011

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In major depression, one line of research indicates that a dysfunctional GABAergic inhibitory system is linked to the appearance of depressive symptoms. However, as the mechanistic details of such GABAergic deficit are largely unknown, we undertook a functional investigation of the GABAergic system in the rat chronic mild stress model of depression. Adult rats were exposed to an eight-week long stress protocol leading to anhedonic-like behavior. In hippocampal brain slices, phasic, and tonic GABA(A) receptor-mediated currents in dentate gyrus granule cells were examined using patch-clamp recordings. In granule cells, the frequency of spontaneous inhibitory postsynaptic currents (sIPSCs) was reduced to 41% in anhedonic-like rats, which was associated with a reduced probability of evoked GABA release. Using immunohistochemical analysis, there was no change in the number of parvalbumin-positive interneurons in the dentate gyrus. Notably, we observed a 60% increase in THIP-activated tonic GABA(A) mediated current in anhedonic-like rats, suggesting an upregulation of extrasynaptic GABA(A) receptors. Finally, five weeks treatment with the antidepressant escitalopram partially reversed the sIPSCs frequency. In summary, we have revealed a hippocampal dysfunction in the GABAergic system in the chronic mild stress model of depression in rats, caused by a reduction in action potential-dependent GABA release. Since the function of the GABAergic system was improved by antidepressant treatment, in parallel with behavioral read outs, it suggests a role of the GABAergic system in the pathophysiology of depression.

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Cognitive deficits in the rat chronic mild stress model for depression: Relation to anhedonic-like responses

Cited by 116 publications

References 49 publications

Chronic selective serotonin reuptake inhibition modulates endothelial dysfunction and oxidative state in rat chronic mild stress model of depression

Chronic selective serotonin reuptake inhibition modulates endothelial dysfunction and oxidative state in rat chronic mild stress model of depression

Adolescent intermittent ethanol exposure does not alter responsiveness to ifenprodil or expression of vesicular GABA and glutamate transporters

Hippocampal GABAergic dysfunction in a rat chronic mild stress model of depression

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