Cognitive Disorders in Juvenile Myoclonic Epilepsy

Шилкина, О. С.; Artyukhov, Ivan; Moskaleva, Polina; Strotskaya, Irina G.; Shnayder, N. А.

doi:10.21103/article7(1)_ra1

Cited by 5 publications

(4 citation statements)

References 56 publications

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“…Brd2+/-haploinsufficient mice showed no cognitive impairment but had behavioral traits similar to those found in JME patients (recklessness, aggression. (9,32) It should be noted that Mendelian JME genes and nonMendelian risk alleles have not been detected in over 90% of affected patients. (33,34) In several patients with JME, AEDs contribute to the psychiatric manifestations; however, it does not mean that antiepileptic drugs need to be stopped.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, the harmful effects on cognition of an early onset of seizure and longer duration of the disease have been well demonstrated. (9) The cause of such disorders may be concomitant nonpsychotic psychiatric disorders, often described with JME. These include various types of anxiety and mood disorders: generalized anxiety disorder, phobias, depression, dysthymia, and psychosomatic disorders.…”

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confidence: 99%

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Nonpsychotic Psychiatric Disorders in Juvenile Myoclonic Epilepsy

Moskaleva¹,

Шилкина²,

Artyukhov³

et al. 2017

IJBM

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The association of epilepsy with mental illness has been described in recent years. Scientists are trying to relate certain epilepsies, such as juvenile myoclonic epilepsy (JME), with certain personality traits marked by emotional instability. The goal of this review is to evaluate the scientific literature about nonpsychotic psychiatric disorders in JME patients, the most common form of idiopathic generalized epilepsy (IGE). Data in this review were collected through an extensive literature search of available full-text publications in PubMed, Springer, Clinical Keys and eLIBRARY.RU databases. Comorbid personality and nonpsychotic psychiatric disorders are a common and interdisciplinary problem in JME management. The disorders in patients with JME often go undiagnosed and hence untreated. Therefore, this problem requires further and extensive investigation.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Nonpsychotic Psychiatric Disorders in Juvenile Myoclonic Epilepsy

Moskaleva¹,

Шилкина²,

Artyukhov³

et al. 2017

IJBM

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“…These disorders, which are a consequence of frontal dysfunction in a number of patients, can lead to poor compliance with doctor's recommendations and unhealthy behavior, which affects their treatment and rehabilitation of patients with JME. The intelligence of patients with JME does not suffer, but in 20-25% of cases there are comorbid cognitive disorders [51].…”

Section: Comorbid Disorders and Juvenile Myoclonic Epilepsymentioning

confidence: 99%

Juvenile myoclonic epilepsy: current state of the problem

Shnayder

Petrov

2021

jour

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Due to the high prevalence of the disease, its genetic and clinical heterogeneity, the need for lifelong therapy and the emergence of new views on the pathogenesis and course of JME, it is necessary to provide primary care physicians (general practitioners, district therapists, neurologists) with up-to-date systematized information about the most common form of genetic generalized epilepsy (Herpin-Janz syndrome). JME is a genetically determined disease of the brain, accompanied by a triad of seizures (absences, myoclonia, generalized tonic-clonic seizures), and developing mainly in adolescence and young age. In recent years, monogenic and multifactorial forms of JME have been identified, but questions about the genetics of JME are far from being resolved. JME is characterized by the preservation of intelligence, life expectancy with adequate therapy does not differ from the average population, but the frequency of failures of pharmaco-induced remission is high when taking anticonvulsants is canceled. This explains the need for lifelong pharmacotherapy, individual selection of anticonvulsants. About 30% of patients with JME have non-psychotic mental disorders, disorders of the sleep and wake cycle, which in turn leads to an aggravation of epileptic seizures mainly in the first half of the day. This review presents an analysis of full-text publications in Russian and English over the past five years in the databases eLibrary, PubMed, Web of Science, OxfordPress, Springer, and Clinicalkeys. In addition, the review includes earlier publications of historical significance.

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“…According to our previous review of the scientific literature about cognitive impairment in patients with JME (Shilkina et al, 2017), four theories the causes of cognitive disorders in JME are currently being advanced:…”

Section: Introductionmentioning

confidence: 99%

Individual neuropsychological characteristics in patients with juvenile myoclonic epilepsy

Moskaleva¹,

Шилкина²,

Шнайдер³

2018

Psych. Rus.

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Background. An association between juvenile myoclonic epilepsy (JME) and nonpsychotic psychiatric and cognitive disorders has been described in recent years. Scientists are trying to link JME with certain personality traits marked by emotional instability. Objective. The goal of our research was to assess the state of cognitive functions in young adult patients with JME-excluding the adverse side effects (ASEs) of antiepileptic drugs (AEDs)-and analyze the level of personality and situational anxiety, neuroticism, and depression in young adult patients with JME. Design. We tested 26 patients with JME and 26 healthy adults with the computer program NS-PsychoTest (Neurosoft Company, RF), a program which is aimed at studying and evaluating neuropsychological characteristics. Results. Our study showed that the frequency of depressive symptoms, according to the cognitive-affective subscale (Beck's Depression Inventory), in patients with JME was statistically significantly higher than among people without epilepsy. Comorbid personality and nonpsychotic psychiatric disorders are common interdisciplinary problems in JME management. Most practitioners pay attention only to the treatment of seizures caused by JME, and their patients, accordingly, do not receive adequate psychotherapeutic help. Conclusion. Cognitive disorders are often associated with epilepsy, and are a result of a combination of factors. According to our study, in the presence of statistically significant differences in short-term memory and mental performance in patients with JME, compared to healthy young adults, the main indicators of cognitive function in patients with JME generally correspond to the norm. Our findings highlight the etiological heterogeneity of cognitive disorders in JME and the importance of early screening for them.

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Cognitive Disorders in Juvenile Myoclonic Epilepsy

Cited by 5 publications

References 56 publications

Nonpsychotic Psychiatric Disorders in Juvenile Myoclonic Epilepsy

Nonpsychotic Psychiatric Disorders in Juvenile Myoclonic Epilepsy

Juvenile myoclonic epilepsy: current state of the problem

Individual neuropsychological characteristics in patients with juvenile myoclonic epilepsy

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