2014
DOI: 10.1177/070674371405901206
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Cognitive Dysfunction in Major Depressive Disorder: Effects on Psychosocial Functioning and Implications for Treatment

Abstract: Major depressive disorder is a common condition with a high rate of recurrence, chronicity, and staggering economic burden, including disability in the workforce.1 In 2010, MDD was the second leading medical cause of burden globally, with highest estimates of disability in people of working age.2 In Canada, the annual prevalence of MDD is 3% to 4% overall, and 79% of people with MDD report some interference with work functioning, either decreased work productivity and (or) absenteeism.1 In addition to work imp… Show more

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Cited by 343 publications
(235 citation statements)
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References 63 publications
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“…This impacts negatively on functional independence, educational and occupational attainment, and quality of life 4, 5, 6, 7, and cognitive improvement is therefore an increasing focus of treatment development efforts 8, 9, 10. Estimates of cognitive impairment prevalence in euthymic adults with mood disorder vary considerably, ranging from 5% to 58% in adults with bipolar disorder (BD) 11, and from one‐third to one‐half in those with major depressive disorder 12.…”
Section: Introductionmentioning
confidence: 99%
“…This impacts negatively on functional independence, educational and occupational attainment, and quality of life 4, 5, 6, 7, and cognitive improvement is therefore an increasing focus of treatment development efforts 8, 9, 10. Estimates of cognitive impairment prevalence in euthymic adults with mood disorder vary considerably, ranging from 5% to 58% in adults with bipolar disorder (BD) 11, and from one‐third to one‐half in those with major depressive disorder 12.…”
Section: Introductionmentioning
confidence: 99%
“…Indeed, deficits in cognitive performances are found in major depressive disorders. 38 Moreover, the higher prevalence of antidepressant use may partly account for the higher prevalence of cognitive impairment in patients compared to controls due to its sedative and anticholinergic effects. The dose, time since last administration, and plasma concentration of the drug, however, determine the extent to which cognitive performance is affected.…”
Section: 15mentioning
confidence: 99%
“…Less research has been dedicated to determining the extent of cognitive deficits in MDD than has in severe mental illness such as schizophrenia and bipolar disorder [3], possibly because of the belief that these deficits are entirely caused by mood states. The impact of cognitive dysfunction on psychosocial function has also been relatively underevaluated [3,4]. Based on evidence that cognitive deficits may persist when other symptoms and core features of MDD resolve may indicate the need for a reconceptualization of symptomatic remission in MDD [3], much as functional remission has become a topic of discussion in other conditions such as schizophrenia [5].…”
Section: Major Depressive Disorder Characteristicsmentioning
confidence: 99%
“…Lam et al [4] hypothesized that the sometimes seemingly resistant functional outcomes (psychosocial and vocational outcomes) in MDD may be mediated by neurocognitive deficits, which also do not universally and reliably improve alongside symptoms. Lam et al [4] reviewed the literature examining deficits in neuropsychological functioning including attention, learning, working memory, visual and auditory processing, processing speed, motor functioning, and problem solving in the context of MDD.…”
Section: Major Depressive Disorder Characteristicsmentioning
confidence: 99%