Cognitive dysfunctions in parents of schizophrenic patients parallel the deficits found in patients

Appels, Melanie C.M.; Sitskoorn, Margriet M.; Westers, Paul; Lems, Elleke B. T. E.; Kahn, René S.

doi:10.1016/s0920-9964(02)00342-0

Cited by 45 publications

(28 citation statements)

References 33 publications

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“…In fact, impaired speed of processing has been found not only in patients with schizophrenia, but also in subjects at high risk for developing psychosis 62,63 , in patients with first-episode schizophrenia spectrum disorders 64 , and in healthy relatives of schizophrenia patients 65,66 . The relationship between speed of processing and functioning found in the present study has also been described by other authors.…”

Section: Discussionmentioning

confidence: 99%

Neurocognition, social cognition and functional outcome in schizophrenia

et al. 2014

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SPAINABSTRACT -Background and Objectives: A relationship has been found between cognition and functioning in patients with schizophrenia. Our objective was to study the relationship between the cognitive domains assessed by the MATRICS Consensus Cognitive Battery (MCCB), and functioning as evaluated using the functioning subscale of the Global Assessment of Functioning scale (GAF-f).Methods: A sample of 83 clinically stable outpatients diagnosed with schizophrenia according to DSM-IV criteria were assessed using the MCCB and the GAF-f. Pearson correlations and stepwise linear regression analyses were performed.Results: Correlation analysis between the GAF-f and the cognitive domains of the MCCB showed a significant relationship between functioning and all of the cognitive domains. Regression yielded a statistically significant model (F 2,74 = 20.4, p < 0.001) in which functioning was related to Speed of processing (standardized β = 0.369, p = 0.001) and to Social cognition (standardized β = 0.325, p = 0.003). Together, these two variables explained 33.8% of the variance of functioning.Conclusions: Both speed of processing and social cognition have an important association with functioning in patients with schizophrenia.

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Section: Discussionmentioning

confidence: 99%

Neurocognition, social cognition and functional outcome in schizophrenia

et al. 2014

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“…Recent ERP research has focused increasingly on the identification of possible indices of disposition to schizophrenia (16,18,28). Among the deficits under the lens, the auditory mismatch negativity has generated particularly vigorous research interest, given its generally robust impairment in patients with the disease.…”

Section: Discussionmentioning

confidence: 99%

Are Auditory-Evoked Frequency and Duration Mismatch Negativity Deficits Endophenotypic for Schizophrenia? High-Density Electrical Mapping in Clinically Unaffected First-Degree Relatives and First-Episode and Chronic Schizophrenia

Magno¹,

Yeap²,

Thakore³

et al. 2008

Biological Psychiatry

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“…The few past studies on cognitive functions in parents of patients with schizophrenia have not differentiated parents with respect to genetic loading [17,18,20,22,29]. One way of investigating genetic loading is to study the relatives of patients with SS and relatives of patients with FS separately, as in the study of Birkett et al [43 ]on executive functions.…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, studies investigating cognitive functions in healthy relatives of patients with schizophrenia have reported divergent findings. Several studies have uncovered executive function impairment in healthy relatives [13,14,15,16,17,18,19,20,21] along with memory [15,16,17,18] and attention [17,19] deficits. Other studies found impairments neither in executive functioning [22,23,24] nor in memory [24] or attentional functioning [24,25].…”

Section: Introductionmentioning

confidence: 99%

Executive Functions in Patients with Familial versus Sporadic Schizophrenia and Their Parents

et al. 2012

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Background: The aim of this study was to investigate the executive functions in patients with sporadic schizophrenia (SS) and familial schizophrenia (FS), and the executive functions in their parents. Methods: The study included 30 patients with FS and their 37 parents with a positive family history of schizophrenia; 30 patients with SS and their 44 parents; 30 controls matched with the patients for gender, age and education, and 40 controls matched with the parents for gender, age and education (211 subjects in total). All the subjects were interviewed with the Structured Clinical Interview for DSM-IV-Axis I (SCID-I). The executive functions were assessed using the Verbal Fluency Test (VFT), the Trail Making Test (TMT), the Wisconsin Card Sorting Test (WCST) and the Stroop Test. Results: Patients with FS and their parents, and patients with SS performed significantly worse than their controls on the VFT, TMT, WCST and the Stroop test. There were no statistically significant differences between parents of patients with SS and their controls on any of the tests except for the Stroop color score. FS parents performed significantly worse than SS parents on all tests. FS patients performed significantly worse than SS patients on the VFT, TMT, Stroop test. Conclusion: Previous studies that investigated the cognitive functions of relatives of patients with schizophrenia brought out inconsistent results. The present study investigated relatives with and without a family history of schizophrenia separately and found that executive functions were impaired only in parents with a positive family history of schizophrenia. These findings suggest that impairment in executive functions may represent a genetic endophenotype for schizophrenia.

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Cognitive dysfunctions in parents of schizophrenic patients parallel the deficits found in patients

Cited by 45 publications

References 33 publications

Neurocognition, social cognition and functional outcome in schizophrenia

Neurocognition, social cognition and functional outcome in schizophrenia

Are Auditory-Evoked Frequency and Duration Mismatch Negativity Deficits Endophenotypic for Schizophrenia? High-Density Electrical Mapping in Clinically Unaffected First-Degree Relatives and First-Episode and Chronic Schizophrenia

Executive Functions in Patients with Familial versus Sporadic Schizophrenia and Their Parents

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