Cognitive function in children with brain tumors in the first year after diagnosis compared to healthy matched controls

Shortman, Robert I.; Lowis, Stephen P.; Penn, Anthony; McCarter, Renée J.; Hunt, Linda; Brown, Caroline; Stevens, Michaël C.G.; Curran, Andrew; Sharples, Peta M.

doi:10.1002/pbc.24746

Cited by 38 publications

(38 citation statements)

References 46 publications

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“…Longitudinal studies are more rare, but have also pointed to a decline over time in global IQ and most neuropsychological indices among patients with brain tumors. Linear modeling suggests declines of 1.5–2 points per year in first 5 years post radiotherapy treatment for brain tumors, without consistent evidence of nadir or leveling off …”

Section: Resultsmentioning

confidence: 99%

Monitoring and Assessment of Neuropsychological Outcomes as a Standard of Care in Pediatric Oncology

Annett

Patel

Phipps

2015

Pediatric Blood & Cancer

102

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Central nervous system cancers or exposure to CNS‐directed therapies increase risk for neuropsychological deficits. There are no accepted guidelines for assessment of neuropsychological functioning in this population. A multifaceted literature search was conducted and relevant literature reviewed to inform the guidelines. Studies of neuropsychological outcomes are widely documented in the pediatric oncology literature. There is strong evidence of need for neuropsychological assessment, but insufficient evidence to guide the timing of assessment, nor to recommend specific interventions. Children with brain tumors and others at high risk for neuropsychological deficits should be monitored and assessed for neuropsychological deficits. Pediatr Blood Cancer 2015;9999:1–52. © 2015 Wiley Periodicals, Inc.

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Section: Resultsmentioning

confidence: 99%

Monitoring and Assessment of Neuropsychological Outcomes as a Standard of Care in Pediatric Oncology

Annett

Patel

Phipps

2015

Pediatric Blood & Cancer

102

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“…However, three other patients in this cohort, who only had CSF diversion surgery for their tectal plate gliomas, had significant deficits on neuropsychological testing. This suggests that the presence of a brain tumor, prior neurosurgery or prior hydrocephalus could impact neurocognitive outcome and school functioning [24].…”

Section: Discussionmentioning

confidence: 99%

Pediatric tectal plate gliomas: a review of clinical outcomes, endocrinopathies, and neuropsychological sequelae

et al. 2015

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Pediatric tectal plate gliomas are indolent slow-growing gliomas that often present with increased intracranial pressure or incidentally on routine brain imaging. We investigated clinical outcomes, endocrinopathies, and neuropsychological sequelae associated with tectal plate gliomas. Twenty-six patients with tectal plate glioma were identified in a 20-year retrospective review. Clinical outcomes, treatments, endocrine function, neuropsychological testing outcomes and radiographic imaging were reviewed for possible signs correlating with tumor progression. Among 26 patients, 19 presented with signs or symptoms of increased intracranial pressure (73 %) versus an incidental finding in 7 (27 %). Median follow-up was 46 months (range 8-143 months). Six of 26 (23 %) experienced progressive disease after diagnosis. Five of 26 (19 %) required more than one surgical procedure due to failure of initial endoscopic third ventriculostomy. Seven of 26 had history of endocrine dysfunction, of which, five presented with endocrine dysfunction (precocious puberty or short stature), 1 developed menstrual irregularities after surgical intervention and 1 had preexisting pan hypopituitarism. Of 12 patients with available neuropsychological testing, eleven had at least one indicator of executive functioning in the low-average to impaired range. While tectal plate gliomas have been considered indolent tumors that are rarely progressive, 23 % of patients in our cohort experienced disease progression and required further therapy. Neurocognitive deficits may occur, while endocrine deficiency is uncommon. Regular multidisciplinary oncology follow-up, routine monitoring with MRI and formal neurocognitive evaluation are imperative to provide early recognition of disease progression or recurrent hydrocephalus and to improve school functioning in this population.

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“…Another study examining the effect of chemotherapy‐only treatment on cognitive outcomes found this treatment to be strongly related to attention deficits in survivors of childhood acute lymphoblastic leukemia . Studies have also suggested a relation between hydrocephalus and attentional deficits . In fact, both chemotherapy and hydrocephalus have been linked to reduced white matter volume, which is reported to be strongly related to attentional deficits .…”

Section: Discussionmentioning

confidence: 99%

The Neurological Predictor Scale: A predictive tool for long‐term core cognitive outcomes in survivors of childhood brain tumors

Taiwo

King

2016

Pediatric Blood & Cancer

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Cognitive function in children with brain tumors in the first year after diagnosis compared to healthy matched controls

Abstract: Early cognitive impairment is present in BT children, sometimes prior to radiotherapy/chemotherapy treatment, and is associated with hydrocephalus, high tumor grade and infratentorial site. Future studies should investigate the role of early rehabilitation in improving cognition.

Cited by 38 publications

References 46 publications

Monitoring and Assessment of Neuropsychological Outcomes as a Standard of Care in Pediatric Oncology

Monitoring and Assessment of Neuropsychological Outcomes as a Standard of Care in Pediatric Oncology

Pediatric tectal plate gliomas: a review of clinical outcomes, endocrinopathies, and neuropsychological sequelae

The Neurological Predictor Scale: A predictive tool for long‐term core cognitive outcomes in survivors of childhood brain tumors

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