Cognitive Impairment and Associated Factors Among Chronic Kidney Disease Patients: A Comparative Cross-Sectional Study

Gela, Yibeltal Yismaw; Getu, Ayechew Adera; Adane, Aynishet; Ayal, Bezawit Mulat; Akalu, Yonas; Ambelu, Adugnaw; Diress, Mengistie; Yeshaw, Yigizie

doi:10.2147/ndt.s304543

Cited by 18 publications

(11 citation statements)

References 65 publications

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“…In this study, getting older was associated with cognitive decline. This finding is in line with studies done in Cameroon 6 , Jamaica 5 , and Ethiopia 27 . The reason might be that as aging increase there is a decrement in neurotransmitters, gray matter volume, and neocortical synapses that result in cognitive impairment 33 – 35 .…”

Section: Discussionsupporting

confidence: 92%

“…Khat chewers or cigarette smokers are those participants who had used khat or cigarettes in the previous month, while those individuals who had consumed alcohol that could cause intoxication in the previous month were alcohol drinkers 27 , 28 .…”

Section: Methodsmentioning

confidence: 99%

“…Participants with BMI of < 18.5 kg/m 2 , (18.5–24.9 kg/m 2 ), (25–29.9 kg/m 2 ), ≥ 30 kg/m 2 were classified as underweight, normal, overweight and obese, respectively 27 .…”

Section: Methodsmentioning

confidence: 99%

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Cognitive impairment and associated factors among mature and older adults living in the community of Gondar town, Ethiopia, 2020

Gela

Fekadu

Belsti

et al. 2022

Sci Rep

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Cognitive impairment and dementia are age-related major public health concerns in the elderly population. It is a major cause of disability, dependency, and poor quality of life. However, in Ethiopia, the magnitude of this cognitive impairment among the elderly community was not investigated. Hence, this study sought to determine the prevalence of cognitive impairment and associated factors among mature and older adults living in the community of Gondar town, Ethiopia, in 2020. A community-based cross-sectional study was conducted at Gondar town, from February 20 to April 30, 2020. Using a single-stage cluster sampling technique, 403 study participants were recruited. Data was collected by a pretested interviewer-administered structured questionnaire which consisting of sociodemographic variables, the Oslo Social Support Scale, and a Standardized Mini-mental State Examination (SMMSE) tool. Epi data version 3.0 was used to enter coded data and then exported into STATA 14 for analysis. Variables with a p-value < 0.25 in the bi-variable logistic regression were included in the multivariable regression. From multivariable logistic regression, variables having a p-value ≤ 0.05 were declared as statistically significant variables. In this study, a total of 403 study participants were involved, and 393 (97.5%) of them completed the survey. Among older participants screened for cognitive impairment, 43.8% was positive for cognitive impairment with a 95% CI (38.8–48.7%). The majority of the participants were (57.5%) male and (44.8%) aged over 60 years. After adjustment, the variables associated with cognitive impairment were age ≥ 75 years [odds ratio (OR) = 7.03, 95% CI 2.78–17.77] and between 61 and 74 years [OR = 3.18, 95% CI 1.81–5.59], and unable to read and write [OR = 5.05, 95% CI 2.04–12.50], low income level [OR = 2.60, 95% CI 1.26–5.20], being female [OR = 2.52, 95% CI 1.50–4.26], poor social support [OR = 2.50, 95% CI 1.30–4.81], and rural residence [OR = 2.39, 95% CI 1.26–4.51]. The prevalence of older participants who screened positively for cognitive impairment was high at Gondar town. The independent predictors of cognitive impairment among older individuals were older age, being unable to read and write, being female, low income, poor social support, and rural dwelling. Therefore, routine screening and social support, as well as free healthcare services for the mature and older community, are needed. Moreover, we strongly recommend the next researcher to use a diagnosis tool to estimate the actual prevalence of the problems among older people.

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Section: Discussionsupporting

confidence: 92%

Section: Methodsmentioning

confidence: 99%

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Cognitive impairment and associated factors among mature and older adults living in the community of Gondar town, Ethiopia, 2020

Gela

Fekadu

Belsti

et al. 2022

Sci Rep

Self Cite

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“…Previous studies demonstrated increasing frequency of cognitive functions impairment and deterioration of cognition in hemodialysis patients [ 8 , 45 ]. On the other hand, there is evidence that HD itself accelerates cognitive impairment compared to peritoneal dialysis [ 37 - 41 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Hemodiafiltration Versus Hemodialysis on Cognitive Function Among Patients With End-Stage Renal Disease: A Multicenter Study

Kashgary¹,

Khojah²,

Bamalan³

et al. 2021

Cureus

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Background: Cognitive impairment (CI) and dementia are common in patients with end-stage renal disease (ESRD) undergoing hemodialysis. Their cause is multifactorial. Our study is first to compare the impact of hemodialysis (HD) and online hemodiafiltration (HDF) on patients’ cognitive outcomes. Methods: This was a cross sectional, multicenter cohort study. Adult ESRD patients aged >18 years on regular high flux HD or online HDF were recruited in the study. Clinical, laboratory, daily activities and cognitive functions assessment were assessed in all the involved individuals. Results: A total of 241 patients were successfully recruited into the study: 164 treated with high flux HD and 77 treated with HDF. Hypertension and diabetes were the commonest associated comorbidities. 85.9% of patients were functionally independent with no significant difference between those on HD versus HDF. 81.3% of our patients showed different degrees of CI. HDF has no superiority in the improvement of cognitive functions. Age, vitamin D level and haemoglobin (Hb) were the most independent predictors of cognitive function impairment among HD patients. Conclusions: Cognitive function impairment is a common problem in hemodialysis and is associated with multiple risk factors. HDF showed no beneficial effect over HD. There is no superiority of online HDF versus high flux HD in improving cognitive functions.

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“…Several current studies have shown that the combination of hypovitaminosis D and chronic kidney disease causes cognitive impairment to occur more rapidly and with greater severity. 17,18 This study aims to explore the role of vitamin D levels with cognitive function in patients with chronic kidney disease.…”

mentioning

confidence: 99%

Serum Vitamin D Levels Related to Cognitive Function in Chronic Kidney Disease Patients

2022

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Background: Vitamin D acts as a neuroprotector and modulator in the central nervous system. Hypovitaminosis is a risk factor for cognitive dysfunction. Hypovitaminosis D and impaired cognitive function are common in patients with chronic kidney disease. Impaired cognitive function is comorbid that can increase the morbidity and mortality of patients with chronic kidney disease. This study aims to assess the relationship between serum vitamin D levels and cognitive function in patients with chronic kidney disease. Methods: This research is an observational study with a cross-sectional approach. A total of 60 research subjects participated in this study. Sociodemographic data, cognitive function, and vitamin D levels were analyzed in this study. Data analysis was performed with SPSS 25 to perform univariate and bivariate tests. Results: The impaired cognitive function was found in 56.7% of CKD patients. The median serum vitamin D level of patients with chronic kidney disease with impaired cognitive function was 30.80 ng/mL and without impaired cognitive function 42.98 ng/mL. There was a significant relationship between serum vitamin D levels and impaired cognitive function (OR=4.125, p=0.035). The cut-off point of serum vitamin D levels associated with impaired cognitive function in CKD patients was 34.8 ng/mL (sensitivity 64.7% and specificity 69.2%). Conclusion:There is a significant relationship between serum vitamin D levels and the incidence of cognitive dysfunction in patients with chronic kidney disease. The cut-off point for serum vitamin D levels associated with impaired cognitive function in chronic kidney disease is 34.8 ng/mL.

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Cognitive Impairment and Associated Factors Among Chronic Kidney Disease Patients: A Comparative Cross-Sectional Study

Cited by 18 publications

References 65 publications

Cognitive impairment and associated factors among mature and older adults living in the community of Gondar town, Ethiopia, 2020

Cognitive impairment and associated factors among mature and older adults living in the community of Gondar town, Ethiopia, 2020

Effect of Hemodiafiltration Versus Hemodialysis on Cognitive Function Among Patients With End-Stage Renal Disease: A Multicenter Study

Serum Vitamin D Levels Related to Cognitive Function in Chronic Kidney Disease Patients

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