AbstrakStroke merupakan penyakit akibat gangguan peredaran darah otak yang dipengaruhi oleh banyak faktor risiko terdiri dari yang tidak dapat diubah berupa usia dan jenis kelamin dan yang dapat diubah seperti hipertensi, peningkatan kadar gula darah, dislipidemia, dan pekerjaan. Penelitian ini bertujuan untuk mengetahui distribusi tipe stroke dan faktor risiko yang berpengaruh pada pasien stroke rawat inap di RSUD Kabupaten Solok Selatan. Metode penelitian: Penelitian ini adalah penelitian deskriptif dengan menggunakan data skunder pasien stroke yang dirawat di RSUD Solok Selatan. Data yang diambil meliputi usia, jenis kelamin, tekanan darah, kadar gula darah, profil lipid saat pertama pasien masuk rumah sakit, dan pekerjaan. Sampel penelitian adalah seluruh pasien stroke yang pernah dirawat di Bagian Penyakit Dalam RSUD Kabupaten Solok Selatan pada periode 1 Januari 2010 -31 Juni 2012 yang memenuhi kriteria inklusi. Hasil penelitian: Hasil penelitian menunjukkan proporsi stroke terbanyak adalah stroke ischemic (61,46%), perempuan (54,17%) yang berusia >50 tahun (81,25%) yang bekerja sebagai ibu rumah tangga (43,75%). Faktor risiko yang dapat diubah tertinggi adalah hipertensi (82,30%) diikuti kolesterol total meningkat (69,79%). Faktor risiko tertinggi pada stroke ischemic adalah gula darah meningkat (47,89%) dan pada stroke hemorrhagic adalah hipertensi (100,00%). Faktor risiko tertinggi pada seluruh pasien adalah hipertensi (82,30%). Kesimpulan: Berdasarkan hasil penelitian ini disimpulkan bahwa stroke tipe ischemic lebih banyak dari tipe hemorrhagic dengan faktor risiko utama hipertensi, sedangkan stroke ischemic terutama dipengaruhi oleh peningkatan gula darah. Kata kunci: stroke ischemic, stroke hemorrhagic, faktor risiko stroke AbstractStroke is a disease caused by disorder of brain blood circulation with many risk factors that contribute in this disease, consist of non modifiable risk factor including age and sex and modifiable risk factors example hypertension, high glucose level, dyslipidemia, and jobs. This study aimed to determine the distribution of the type of stroke and the risk factors that affect to stroke patients who were treat in South Solok hospital.Methods: This research is descriptive research using secondary data, including the patient's medical record. The data including age, gender, blood pressure, glucose level, lipid profile when the first patient in the hospital, and jobs. The samples were all stroke patients who had been treat in the Department of Internal Medicine of South Solok hospital in the period from January 1st 2010 until June 31th 2012 that meet the inclusion criteria.The results: The results showed the highest proportion of strokes were ischemic stroke (61.46%), women (54.17%) aged> 50 years (81.25%) who work as housewives (43.75%). The highest of modifiable risk factors are hypertension (82.30%) followed by increases in total cholesterol (69.79%). The highest risk factors for ischemic stroke is high glucose level (47.89%) and for hemorrhagic stroke is hypertension (100.00...

Kemajuan teknologi dan industri berdampak kepada peningkatan kualitas kesehatan. Tujuan penelitian ini adalah menentukan hubungan faktor risiko seperti pertambahan usia, jenis kelamin, stresor sosial, tingkat pendidikan, penyakit yang pernah diderita dan pekerjaan terhadap fungsi kognitif lanjut usia. Penelitian dilakukan dengan studi potong lintang menggunakan data hasil Tes MoCA-Ina. Penelitian dilakukan di kecamatan Padang Panjang Timur pada tahun 2014. Hasil analisis data dengan chi-square didapatkan bahwa sebagian besar responden adalah usia lanjut (60,8%), berjenis kelamin perempuan (71,1%), memiliki tingkat pendidikan rendah (61,9%), dan tidak memiliki riwayat penyakit (gangguan kardiovaskular, diabetes, kejang, dan trauma kepala) (51,5%). Analisis bivariat didapatkan usia dengan fungsi kognitif (p = 0,001), jenis kelamin dengan fungsi kognitif (p = 0,100), tingkat pendidikan dengan fungsi kognitif (p = 0,017), dan riwayat penyakit dengan fungsi kognitif (p = 0,394). Hasil penelitian ini dapat disimpulkan bahwa terdapat hubungan bermakna antara usia dan tingkat pendidikan terhadap fungsi kognitif lanjut usia. Pada jenis kelamin dan riwayat penyakit tidak terdapat hubungan bermakna.

A few studies have shown that serum brain-derived neurotrophic factor (BDNF) level in post-stroke depression is highly correlated with memory and neuropsychiatric disturbances. Objective: This study aimed to elucidate the relationship of serum BDNF, malondialdehyde (MDA), and 8-Hydroxy 2-Deoxyguanosine (8-OhdG) levels in acute stroke cases with one-month post-stroke depression. Methods: An observational study was conducted of 72 post-ischemic stroke patients in the Neurology ward of the Dr. M. Djamil Hospital, Padang, West Sumatra, Indonesia. Acute stroke (< 48 hours) serum BDNF, MDA, and 8-OhdG levels were measured using ELISA. Based on observations using the Hamilton Depression Rating Scale conducted one month after stroke, respondents were divided into two groups: with and without depression. The mean serum level was analyzed using the t-test and Mann-Whitney test, while differences in basic characteristics were analyzed using the Chi-square test. Multivariate analysis was conducted to determine the most significant factor associated with post-stroke depression. The error rate was set at 5%. Results: BDNF levels in acute stroke were significantly lower in the depression group than in the non-depression group (p < 0.05). MDA and 8-OhdG levels in acute stroke were higher in the depression group (p < 0.05). BDNF level during acute stroke was negatively correlated with post-stroke depression, while, conversely, acute stroke MDA and 8-OhdG levels were positively correlated with depression. Conclusion: BDNF had a negative correlation, while MDA and 8-OhdG had a positive correlation, with depression one-month post-stroke. 8-OhdG was the most influential factor in post-stroke depression.

AIM:This study was conducted to identify malondialdehyde (MDA) serum level, nerve growth factor (NGF) serum level, diabetic peripheral neuropathy score and the correlation between MDA and NGF serum level with diabetic peripheral neuropathy score.METHODS:A cross-sectional study was conducted to observe diabetic patients in the internal medicine department in Dr M. Djamil Hospital, Padang, Indonesia. The MDA serum level was measured using Beuge method with thiobarbituric acid. The NGF serum level was analysed using ELISA method. Diabetic peripheral neuropathy score was defined when history score in Michigan Neuropathy Screening Instrument (MNSI) ≥ 7 and physical assessment score in MNSI > 2.RESULTS:Thirty subjects with diabetes has diabetic peripheral neuropathy score 3.53 (± 0.91), MDA serum level 2.16 (± 2.89) nmol/ml, and NGF serum level 10.56 (± 2.89) pg/dl. There were significant correlations between the MDA serum level and the diabetic peripheral neuropathy score (r = 0.364, p = 0.048), and between the NGF serum level with the diabetic peripheral neuropathy score (r = -0.59, p = 0.001).CONCLUSION:There are high MDA serum level and low NGF serum level in patients with diabetic peripheral neuropathy. Low NGF serum level plays a bigger role than high MDA serum level in diabetic peripheral neuropathy.

AbstrakKandungan ASI sangat penting bagi perkembangan sel otak yang dapat mempengaruhi perkembangan psikomotorik bayi. Sama halnya stimulasi psikososial, anak dapat mengendalikan dan mengkoordinasikan otot serta melibatkan perasaan emosi dan pikiran sehingga mempengaruhi kemampuan dasar perkembangan bayi. Tujuan penelitian ini adalah untuk mengetahui hubungan pemberian ASI eksklusif dan stimulasi psikososial dengan Perkembangan bayi berumur 6 -12 bulan. Desain penelitian adalah cross sectional. Penelitian telah dilakukan pada bulan juni 2017 -Juli 2018. Sampel penelitian adalah semua ibu yang memiliki bayi berumur 6 -12 bulan memenuhi kriteria penelitian secara consecutive sampling. Peneliti melakukan wawancara dan observasi pada ibu dan bayi. pengolahan dan analisis data secara komputerisasi dengan uji Chi-Square dan uji Mantel-Haenszel. Hasil penelitian menunjukkan tidak ada perbedaan signifikan umur ibu (p=0,348 ), jumlah anak (p=0,675) ,pendidikan ibu (p=0,259), jenis kelamin ( p=1,000) dan umur bayi (p=1,000), status gizi (p=0,893) dan ada perbedaan antara ibu bekerja dan ibu tidak bekerja (p=0,023) pada kelompok bayi mendapatkan ASI eksklusif dan kelompok bayi tidak mendapatkan ASI eksklusif. Tidak terdapat hubungan pemberian ASI eksklusif (p=0,317) dan terdapat hubungan (p= 0,000) stimulasi psikososial dengan perkembangan bayi berumur 6 -12 bulan. Simpulan penelitian ini adalah tidak terdapat hubungan pemberian ASI eksklusif dan ada hubungan stimulasi psikososial dengan perkembangan bayi berumur 6 -12 bulan.Kata kunci: ASI eksklusif, stimulasi psikososial, perkembangan bayi AbstractThe content of breast milk is very important for the development of brain cells that can affect the psychomotor development of infants. Similarly, psychosocial stimulation, the child can control and coordinate muscles and involves feelings of emotions and thoughts that affect the baby's basic developmental abilities. The objective of this study was to know the relation exclusive breast feeding and psychosocial stimulation with the development of infant (6-12 months).The design of this research was cross sectional comparative. The research had been done in June 2017 -July 2018. The sample of this research was mothers who have infant age 6-12 months which fulfill the research criteria as consecutive sampling. The researcher did interview and observe mothers and infants. The processing and analyzing data in computerization by Chi-Square test and Mantel Haenszel.The result of the research showed there were no significant differences of mothers age (p = 0,348), amount of children (p = 0,675), mothers education (p= 0,259), gender (p = 1,000) and infants age (p = 1,000), nutritional status (p= 0,893) and there were difference a between working mother and not (p= 0,023) in groups of infant which get exclusive breast feeding and not. There was no relation of exclusive breast feeding (p= 0,317) but there was relation (p= 0,000) psychosocial stimulation with infants development age sixtwelve months.The conclusion of this research is no r...