Cognitive impairment and cerebral structure by MRI in bipolar disorder

Coffman, Jeffrey A.; Bornstein, Robert A.; Olson, Stephen C.; Schwarzkopf, Steven B.; Nasrallah, Henry A.

doi:10.1016/0006-3223(90)90416-y

Cited by 215 publications

(167 citation statements)

References 23 publications

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“…Cognitive impairments have previously been described in FH and also in manic, depressed, and euthymic BD patients (Sobczak et al, 2002c;Rossi et al, 2000;Martinez-Aran et al, 2000;Ferrier et al, 1999;Murphy et al, 1999;Rubinsztein et al, 2000). The cognitive deficits in BD may be partially explained by abnormalities in functional brain structures and/or metabolism (Stoll et al, 2000;Manji et al, 2000;van Gorp et al, 1999;Coffman et al, 1990). As cognitive impairments are present in FH and persist during clinical remission in BD patients, they may be regarded as trait markers (Henry et al, 1973;van Gorp et al, 1998;Murphy et al, 1999;Coffman et al, 1990;Ferrier et al, 1999;Rubinsztein et al, 2000).…”

Section: Discussionmentioning

confidence: 97%

“…The cognitive deficits in BD may be partially explained by abnormalities in functional brain structures and/or metabolism (Stoll et al, 2000;Manji et al, 2000;van Gorp et al, 1999;Coffman et al, 1990). As cognitive impairments are present in FH and persist during clinical remission in BD patients, they may be regarded as trait markers (Henry et al, 1973;van Gorp et al, 1998;Murphy et al, 1999;Coffman et al, 1990;Ferrier et al, 1999;Rubinsztein et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

“…In bipolar disorders (BD), cognitive deficits have been reported repeatedly (Coffman et al, 1990;Savard et al, 1980;Wolfe et al, 1987;Krabbendam et al, 2000). Manic patients showed impairments on planning and reaction time (RT) (Murphy et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

“…Manic patients showed impairments on planning and reaction time (RT) (Murphy et al, 1999). During remission, cognitive deficits may persist (van Gorp et al, 1998;Ferrier et al, 1999;Rubinsztein et al, 2000;Scott et al, 2000); euthymic BD patients showed impairments on visuospatial recognition, verbal and nonverbal memory and learning, retrieval of information from semantic memory an increased RT on a planning task (Coffman et al, 1990;Ferrier et al, 1999;Rubinsztein et al, 2000). The fact that cognitive deficits persist during remission suggests that they constitute a trait marker in BD.…”

Section: Introductionmentioning

confidence: 99%

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Pronounced Cognitive Deficits Following an Intravenous L-Tryptophan Challenge in First-Degree Relatives of Bipolar Patients Compared to Healthy Controls

Sobczak

Honig

Schmitt

et al. 2002

Neuropsychopharmacol

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Cognitive impairment has repeatedly been described in bipolar disorders (BD). Serotonin (5-hydroxytryptophan; 5-HT) is possibly involved in these cognitive processes, more particularly in executive functions, learning, memory, and attention. The aim of this study was to investigate serotonergic vulnerability and its relation to cognitive functioning in healthy first-degree relatives of BD patients. We investigated the effects of an intravenous (i.v.) tryptophan (Trp) challenge and placebo on cognitive performance in 30 healthy firstdegree relatives of bipolar patients (FH) and 15 matched controls in a double-blind crossover design. A distinction was made between relatives of type I BD patients (FH I) and type II BD patients (FH II). Performances on planning, memory, attention, and psychomotor tasks were assessed 3 h after Trp infusion. After Trp, planning and attention were impaired in FH subjects but not in controls. Independent of Trp, FH subjects showed cognitive deficits on memory, focused and divided attention, and psychomotor performance. FH I subjects showed more pronounced cognitive impairments then FH II and controls. In all groups, Trp impaired memory and psychomotor performance significantly. In conclusions, cognitive deficits in FH following Trp may reflect a central 5-HT vulnerability in frontal brain areas. Independent of Trp, cognitive deficits in FH provide evidence for a trait marker for BD.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Pronounced Cognitive Deficits Following an Intravenous L-Tryptophan Challenge in First-Degree Relatives of Bipolar Patients Compared to Healthy Controls

Sobczak

Honig

Schmitt

et al. 2002

Neuropsychopharmacol

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“…Sax e cols. (1999) 21 demonstraram diminuição do volume do córtex pré-frontal de 17 pacientes em estado maníaco, em comparação com 12 controles nor-Neurobiologia do transtorno -Machado-Vieira et alii mais. Diminuição da substância cinzenta no córtex pré-frontal subgenual foi reportado em pacientes com TAB e unipolares com história familiar para transtornos de humor 22 .…”

Section: Estudos Anatômicos (Estruturais)unclassified

Neurobiologia do transtorno de humor bipolar e tomada de decisão na abordagem psicofarmacológica

Machado‐Vieira

Schwartzhaupt²,

Frey

et al. 2003

Rev. psiquiatr. Rio Gd. Sul

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INTRODUÇÃOO Transtorno do Humor Bipolar (THB) caracteriza-se por oscilações do humor que causam prejuízos significativos no âmbito biopsicossocial, com critérios específicos para seus subdiagnósticos (DSM-IV). O surgimento de novos fármacos com propriedade de estabilizar o humor, o refinamento diagnóstico, as estimativas de uma maior prevalência, o risco de suicídio, assim como os prejuízos sociais causados para o indivíduo portador do transtorno, sua família e a sociedade enfatizam a importân-cia de cada vez mais este transtorno ser estudado de forma sistemática, continuada e críti-ca. Este artigo avalia criticamente as opções já estudadas para tratamento farmacológico dos diferentes subtipos de THB, avaliando sua eficácia para as indicações específicas, bem como as perspectivas de novos estudos com fárma-cos que ainda apresentam resultados limitados, especialmente devido à não sistematização dos estudos clínicos feitos até o presente momento. FÁRMACOS UTILIZADOS E MECANISMOS DE AÇÃO LítioO lítio interfere no metabolismo do inositol trifosfato, responsável pela liberação do cálcio de seus depósitos intracelulares, possivelmente através da inibição de enzimas na rota de formação do inositol2,3. Há também outras hipóteses que justificam seu uso como estabilizador do humor:-por sua similaridade com outros elementos (sódio, potássio, cálcio e magnésio), eleva Neurobiologia do transtorno de humor bipolar e tomada de decisão na abordagem psicofarmacológica

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